PMID- 34628665
OWN - NLM
STAT- MEDLINE
DCOM- 20220328
LR  - 20220328
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
VI  - 49
IP  - 3
DP  - 2022 Mar
TI  - Dermatofibrosarcoma protuberans with platelet-derived growth factor-D 
      rearrangement; two cases with morphologically distinct presentations.
PG  - 274-277
LID - 10.1111/cup.14148 [doi]
AB  - Dermatofibrosarcoma protuberans (DFSP) is a mesenchymal neoplasm that is usually 
      located in the dermis or subcutis and is locally aggressive. Rarely, these 
      lesions may undergo fibrosarcomatous transformation, which is thought to increase 
      their metastatic potential. DFSP is classically associated with a 17;22 
      translocation (or ring chromosome thereof) resulting in fusion of the COL1A1 and 
      PDGFB genes. However, variant fusions involving PDGFD have been recently 
      reported. Herein, we present two morphologically diverse cases of DFSP with PDGFD 
      rearrangement. Case 1 is a 68-year-old female with a left dorsal foot lesion. 
      Morphologically, the lesion is unusual as it is a well-circumscribed, 
      hypercellular, subcutaneous nodule with uniform CD34-positive spindle cells 
      arranged in a herringbone pattern without storiform arrangement or "honeycombing" 
      fat entrapment. It was diagnosed as pure fibrosarcomatous DFSP. Case 2 is a 
      37-year-old male with a right supra-auricular lesion. Morphologically, the lesion 
      displays classic DFSP features including bland CD34-positive spindle cells with 
      storiform growth, fat entrapment, and infiltrative borders. Both lesions were 
      negative for COL1A1-PDGFB fusion but positive for PDGFD rearrangement by 
      fluorescence in situ hybridization (FISH) analysis. FISH testing for PDGFD 
      rearrangement should be performed in cases where there is a high suspicion for 
      DFSP but initial studies for COL1A1-PDGFB are negative.
CI  - (c) 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Campbell, Katelynn
AU  - Campbell K
AUID- ORCID: 0000-0002-7855-9424
AD  - Department of Pathology, University of Arkansas for Medical Sciences, Little 
      Rock, Arkansas, USA.
FAU - Bridge, Julia A
AU  - Bridge JA
AD  - Department of Cytogenetics and Fluorescence In-Situ Hybridization, ProPath, 
      Dallas, Texas, USA.
FAU - DiMaio, Dominick
AU  - DiMaio D
AD  - Department of Pathology and Microbiology, University of Nebraska Medical Center, 
      Omaha, Nebraska, USA.
FAU - Wilson, Janice
AU  - Wilson J
AD  - Department of Dermatology, University of Texas Medical Branch, Galveston, Texas, 
      USA.
FAU - Shalin, Sara C
AU  - Shalin SC
AD  - Department of Pathology, University of Arkansas for Medical Sciences, Little 
      Rock, Arkansas, USA.
FAU - Gardner, Jerad M
AU  - Gardner JM
AUID- ORCID: 0000-0001-7397-2159
AD  - Department of Anatomic and Clinical Pathology, Geisinger Medical Laboratories, 
      Danville, Pennsylvania, USA.
LA  - eng
PT  - Case Reports
DEP - 20211019
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
RN  - 0 (Lymphokines)
RN  - 0 (PDGFD protein, human)
RN  - 0 (Platelet-Derived Growth Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Dermatofibrosarcoma/*genetics/pathology
MH  - Female
MH  - *Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphokines/*genetics
MH  - Male
MH  - Platelet-Derived Growth Factor/*genetics
MH  - Skin Neoplasms/*genetics/pathology
OTO - NOTNLM
OT  - PDGFD
OT  - dermatofibrosarcoma protuberans
OT  - fibrosarcomatous transformation
EDAT- 2021/10/11 06:00
MHDA- 2022/03/29 06:00
CRDT- 2021/10/10 21:21
PHST- 2021/09/09 00:00 [revised]
PHST- 2021/05/24 00:00 [received]
PHST- 2021/10/05 00:00 [accepted]
PHST- 2021/10/11 06:00 [pubmed]
PHST- 2022/03/29 06:00 [medline]
PHST- 2021/10/10 21:21 [entrez]
AID - 10.1111/cup.14148 [doi]
PST - ppublish
SO  - J Cutan Pathol. 2022 Mar;49(3):274-277. doi: 10.1111/cup.14148. Epub 2021 Oct 19.