PMID- 34629004
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 1758-1052 (Electronic)
IS  - 0956-4624 (Linking)
VI  - 33
IP  - 1
DP  - 2022 Jan
TI  - Efflorescence of acquired epidermodysplasia verruciformis due to immune 
      reconstitution inflammatory syndrome-like mechanisms following anti-HPV 
      vaccination in a HIV-positive patient.
PG  - 94-96
LID - 10.1177/09564624211048343 [doi]
AB  - Epidermodysplasia verruciformis (EV) is a rare cutaneous pre-cancerous condition 
      characterized by presence of flat, scaly macules, verruca-like papillomatous 
      papules, seborrheic keratosis-like lesions, and pink-red pityriasis 
      versicolor-like macules. The disease is caused by abnormal susceptibility to 
      certain specific beta-HPV subtypes, most commonly 5 and 8. Classic EV is 
      genetically determined, but in immunocompromised individuals, an acquired form 
      can occur. Only 48 cases of acquired EV (AEV) in people living with HIV have been 
      described. We describe a case of AEV in a 36-year-old HIV-positive man with an 
      history of stable optimal CD4 cell count and undetectable HIV viral load. The AEV 
      significantly deteriorated after the administration of the second dose of the 
      quadrivalent anti-HPV vaccine and did not improve despite local treatment, 
      anti-HPV vaccination completion, and persistently optimal combined antiretroviral 
      treatment adherence. To the best of our knowledge, this is the first report of an 
      AEV deterioration with a clinical and temporal pattern mimicking an immune 
      reconstitution inflammatory syndrome (IRIS) following anti-HPV vaccination, 
      instead of low CD4 count restoration. After reviewing the current literature, we 
      have hypothesized a vaccine-mediated IRIS-like phenomenon in the pathogenesis of 
      the disease.
FAU - Parietti, Michele
AU  - Parietti M
AUID- ORCID: 0000-0003-4673-4635
AD  - Department of Medical Sciences, Dermatology Clinic and Surgical Pathology 
      Section, 9314University of Turin, Torino, Italy.
FAU - Trunfio, Mattia
AU  - Trunfio M
AD  - Department of Medical SciencesInfectious Diseases Unit, Amedeo di Savoia 
      Hospital, 120354University of Turin, Torino, Italy.
FAU - Delmonte, Sergio
AU  - Delmonte S
AD  - Department of Medical Sciences, Dermatology Clinic and Surgical Pathology 
      Section, 9314University of Turin, Torino, Italy.
FAU - Conti, Luca
AU  - Conti L
AD  - Department of Medical Sciences, Dermatology Clinic and Surgical Pathology 
      Section, 9314University of Turin, Torino, Italy.
FAU - Trentalange, Alice
AU  - Trentalange A
AD  - Department of Medical SciencesInfectious Diseases Unit, Amedeo di Savoia 
      Hospital, 120354University of Turin, Torino, Italy.
FAU - Bonora, Stefano
AU  - Bonora S
AD  - Department of Medical SciencesInfectious Diseases Unit, Amedeo di Savoia 
      Hospital, 120354University of Turin, Torino, Italy.
FAU - Calcagno, Andrea
AU  - Calcagno A
AUID- ORCID: 0000-0003-2534-8815
AD  - Department of Medical SciencesInfectious Diseases Unit, Amedeo di Savoia 
      Hospital, 120354University of Turin, Torino, Italy.
FAU - Ribero, Simone
AU  - Ribero S
AD  - Department of Medical Sciences, Dermatology Clinic and Surgical Pathology 
      Section, 9314University of Turin, Torino, Italy.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20211011
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
SB  - IM
MH  - Adult
MH  - *Epidermodysplasia Verruciformis/pathology
MH  - *HIV Infections/complications/drug therapy
MH  - Humans
MH  - *Immune Reconstitution Inflammatory Syndrome/complications
MH  - Male
MH  - Papillomaviridae
MH  - Vaccination/adverse effects
OTO - NOTNLM
OT  - human immunodeficiency virus
OT  - human papillomavirus
OT  - vaccination
EDAT- 2021/10/12 06:00
MHDA- 2022/04/05 06:00
CRDT- 2021/10/11 05:25
PHST- 2021/10/12 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/10/11 05:25 [entrez]
AID - 10.1177/09564624211048343 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2022 Jan;33(1):94-96. doi: 10.1177/09564624211048343. Epub 2021 
      Oct 11.