PMID- 34629044
OWN - NLM
STAT- MEDLINE
DCOM- 20220729
LR  - 20220729
IS  - 2212-3911 (Electronic)
IS  - 1574-8863 (Linking)
VI  - 17
IP  - 3
DP  - 2022
TI  - Safety of Intravenous Thrombolysis and Mechanical Thrombectomy in Bilateral 
      Posterior Cerebral Artery Territory Infarction.
PG  - 274-278
LID - 10.2174/1574886316666211008140212 [doi]
AB  - BACKGROUND: Acute bilateral blindness is an uncommon phenomenon that requires 
      immediate diagnosis and action. The emergent evaluation should concentrate on an 
      early distinction between ocular, cortical, and psychogenic etiologies. 
      OBJECTIVE: To present a case of cortical blindness without anosognosia due to the 
      embolic occlusion of both posterior cerebral arteries (PCAs) and treated by 
      intravenous and mechanical thrombolysis. CASE REPORT: A 67-year-old woman was 
      admitted to the Stroke Unit due to cortical blindness without anosognosia. At the 
      admission to the hospital, an emergent computed tomography scan of the brain 
      ruled out intracranial acute hemorrhage and showed subtle changes consistent with 
      hyperacute ischemia of the left occipital cortex, while a CT angiography 
      demonstrated the occlusion of the P3 segment of both right and left posterior 
      cerebral arteries. The patient was treated with combined thrombolysis 
      (intravenous and mechanical thrombolysis), obtaining complete revascularization 
      and a significant clinical improvement. CONCLUSION: Even if there is no 
      randomized controlled trial to compare the effectiveness and safety of mechanical 
      thrombectomy (MT) to intravenous thrombolysis in patients with posterior 
      circulation occlusion, the good outcome of this case encourages combined stroke 
      treatments in posterior circulation stroke, even in case of mild but disabling 
      neurological deficits.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Acampa, Maurizio
AU  - Acampa M
AD  - Department of Emergency-Urgency and Transplants, Azienda Ospedaliera 
      Universitaria Senese, "Santa Maria alle Scotte" General-Hospital, Siena, Italy.
FAU - Guideri, Francesca
AU  - Guideri F
AD  - Department of Emergency-Urgency and Transplants, Azienda Ospedaliera 
      Universitaria Senese, "Santa Maria alle Scotte" General-Hospital, Siena, Italy.
FAU - Bracco, Sandra
AU  - Bracco S
AD  - Interventional Neuroradiology Unit, Azienda Ospedaliera Universitaria Senese 
      University of Siena, Policlinico "Santa Maria alle Scotte" Siena, Italy.
FAU - Tassi, Rossana
AU  - Tassi R
AD  - Department of Emergency-Urgency and Transplants, Azienda Ospedaliera 
      Universitaria Senese, "Santa Maria alle Scotte" General-Hospital, Siena, Italy.
FAU - Domenichelli, Carlo
AU  - Domenichelli C
AD  - Department of Emergency-Urgency and Transplants, Azienda Ospedaliera 
      Universitaria Senese, "Santa Maria alle Scotte" General-Hospital, Siena, Italy.
FAU - Lazzerini, Pietro Enea
AU  - Lazzerini PE
AD  - Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 
      Siena, Italy.
FAU - Cioni, Samuele
AU  - Cioni S
AD  - Interventional Neuroradiology Unit, Azienda Ospedaliera Universitaria Senese 
      University of Siena, Policlinico "Santa Maria alle Scotte" Siena, Italy.
FAU - Martini, Giuseppe
AU  - Martini G
AD  - Department of Emergency-Urgency and Transplants, Azienda Ospedaliera 
      Universitaria Senese, "Santa Maria alle Scotte" General-Hospital, Siena, Italy.
LA  - eng
PT  - Case Reports
PL  - United Arab Emirates
TA  - Curr Drug Saf
JT  - Current drug safety
JID - 101270895
SB  - IM
MH  - Aged
MH  - *Agnosia/complications
MH  - *Blindness, Cortical/complications
MH  - *Brain Ischemia/complications
MH  - Female
MH  - Humans
MH  - Infarction/complications
MH  - Posterior Cerebral Artery/diagnostic imaging
MH  - *Stroke/diagnostic imaging/etiology/therapy
MH  - Thrombectomy/adverse effects/methods
MH  - Thrombolytic Therapy/adverse effects
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Cortical blindness
OT  - Penumbra 4Max
OT  - alteplase
OT  - case report
OT  - mechanical thrombolysis
OT  - posterior cerebral artery
OT  - stent retriever
EDAT- 2021/10/12 06:00
MHDA- 2022/07/30 06:00
CRDT- 2021/10/11 05:27
PHST- 2021/06/27 00:00 [received]
PHST- 2021/07/01 00:00 [revised]
PHST- 2021/08/11 00:00 [accepted]
PHST- 2021/10/12 06:00 [pubmed]
PHST- 2022/07/30 06:00 [medline]
PHST- 2021/10/11 05:27 [entrez]
AID - CDS-EPUB-118388 [pii]
AID - 10.2174/1574886316666211008140212 [doi]
PST - ppublish
SO  - Curr Drug Saf. 2022;17(3):274-278. doi: 10.2174/1574886316666211008140212.