PMID- 34629932
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220813
IS  - 1349-1032 (Print)
IS  - 1349-1032 (Linking)
VI  - 4
DP  - 2007
TI  - Caloric Restriction, Energy Balance and Healthy Aging in Okinawans and Americans: 
      Biomarker Differences in Septuagenarians.
PG  - 60-72
AB  - BACKGROUND: Caloric restriction (CR) is the only consistently reproducible 
      non-genetic means of minimizing age-related diseases and increasing maximum 
      lifespan in short-lived animals but few human studies exist. OBJECTIVE: Since 
      elderly Okinawans exhibit several phenotypic features of CR including low BMI, 
      low prevalence of chronic diseases, and exceptional longevity, we hypothesized 
      that this phenotype may be reflected in candidate biomarkers of human aging. 
      METHODS: We retrospectively estimated adult energy balance across the life course 
      for septuagenarian birth cohorts (born ca 1915-1925) from Okinawa and the U.S. 
      based on archived data. We then compared plasma DHEA, estrogen and testosterone 
      in a sample of community dwelling members from these birth cohorts. RESULTS: 
      Elderly Okinawans had much lower caloric intake than Americans and appeared 
      mildly calorically restricted (10-15%) at younger ages relative to their 
      estimated energy requirements. Okinawans also had significantly higher plasma 
      DHEA, testosterone and estrogen levels as septuagenarians versus non-CR Americans 
      of similar chronological age. CONCLUSION: These cross-sectional data are 
      consistent with the caloric restriction hypothesis in humans and support further 
      longitudinal investigation into biomarkers of human aging and their potential 
      modification by caloric restriction.
FAU - Willcox, Bradley J
AU  - Willcox BJ
AD  - The institute where the work was conducted: Pacific Health Research Institute, 
      University of Hawaii, Okinawa International University, University of the 
      Ryukyus, Okinawa Research Center for Longevity Science.
FAU - Willcox, D Craig
AU  - Willcox DC
AD  - The institute where the work was conducted: Pacific Health Research Institute, 
      University of Hawaii, Okinawa International University, University of the 
      Ryukyus, Okinawa Research Center for Longevity Science.
FAU - Todoriki, Hidemi
AU  - Todoriki H
AD  - The institute where the work was conducted: Pacific Health Research Institute, 
      University of Hawaii, Okinawa International University, University of the 
      Ryukyus, Okinawa Research Center for Longevity Science.
FAU - Yano, Katsuhiko
AU  - Yano K
AD  - The institute where the work was conducted: Pacific Health Research Institute, 
      University of Hawaii, Okinawa International University, University of the 
      Ryukyus, Okinawa Research Center for Longevity Science.
FAU - Curb, J David
AU  - Curb JD
AD  - The institute where the work was conducted: Pacific Health Research Institute, 
      University of Hawaii, Okinawa International University, University of the 
      Ryukyus, Okinawa Research Center for Longevity Science.
FAU - Suzuki, Makoto
AU  - Suzuki M
AD  - The institute where the work was conducted: Pacific Health Research Institute, 
      University of Hawaii, Okinawa International University, University of the 
      Ryukyus, Okinawa Research Center for Longevity Science.
LA  - eng
GR  - K08 AG022788/AG/NIA NIH HHS/United States
PT  - Journal Article
PL  - Japan
TA  - Okinawan J Am Stud
JT  - The Okinawan journal of American studies
JID - 101769582
PMC - PMC8496353
MID - NIHMS163084
OTO - NOTNLM
OT  - Caloric restriction
OT  - DHEA
OT  - Okinawa
OT  - biomarker
OT  - human
OT  - longevity
EDAT- 2007/01/01 00:00
MHDA- 2007/01/01 00:01
PMCR- 2021/10/07
CRDT- 2021/10/11 05:51
PHST- 2021/10/11 05:51 [entrez]
PHST- 2007/01/01 00:00 [pubmed]
PHST- 2007/01/01 00:01 [medline]
PHST- 2021/10/07 00:00 [pmc-release]
PST - ppublish
SO  - Okinawan J Am Stud. 2007;4:60-72.