PMID- 34630014
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211012
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 15
DP  - 2021
TI  - Altered Functional Topological Organization in Type-2 Diabetes Mellitus With and 
      Without Microvascular Complications.
PG  - 726350
LID - 10.3389/fnins.2021.726350 [doi]
LID - 726350
AB  - Microvascular complications can accelerate cognitive impairment in patients with 
      type 2 diabetes mellitus (T2DM) and have a high impact on their quality of life; 
      however, the underlying mechanism is still unclear. The complex network in the 
      human brain is the physiological basis for information processing and cognitive 
      expression. Therefore, this study explored the relationship between the 
      functional network topological properties and cognitive function in T2DM patients 
      with and without microvascular complications (T2DM-C and T2DM-NC, respectively). 
      Sixty-seven T2DM patients and 41 healthy controls (HCs) underwent resting-state 
      functional MRI and neuropsychological assessment. Then, graph theoretical network 
      analysis was performed to explore the global and nodal topological alterations in 
      the functional whole brain networks of T2DM patients. Correlation analyses were 
      performed to investigate the relationship between the altered topological 
      parameters and cognitive/clinical variables. The T2DM-C group exhibited 
      significantly higher local efficiency (Eloc), normalized cluster coefficient (gamma), 
      and small-world characteristics (sigma) than the HCs. Patients with T2DM at different 
      clinical stages (T2DM-C and T2DM-NC) showed varying degrees of abnormalities in 
      node properties. In addition, compared with T2DM-NC patients, T2DM-C patients 
      showed nodal properties disorders in the occipital visual network, cerebellum and 
      middle temporal gyrus. The Eloc metrics were positively correlated with HbA1c 
      level (P = 0.001, r = 0.515) and the NE values in the right paracentral lobule 
      were negatively related with serum creatinine values (P = 0.001, r = -0.517) in 
      T2DM-C patients. This study found that T2DM-C patients displayed more extensive 
      changes at different network topology scales. The visual network and cerebellar 
      may be the central vulnerable regions of T2DM-C patients.
CI  - Copyright (c) 2021 Zhang, Huang, Gao, Lei, Ai, Tang, Yan, Lei, Yang, Shao and 
      Zhang.
FAU - Zhang, Dongsheng
AU  - Zhang D
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Huang, Yang
AU  - Huang Y
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Gao, Jie
AU  - Gao J
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Lei, Yumeng
AU  - Lei Y
AD  - Department of Graduate, Xi'an Medical University, Xi'an, China.
FAU - Ai, Kai
AU  - Ai K
AD  - Department of Clinical Science, Philips Healthcare, Xi'an, China.
FAU - Tang, Min
AU  - Tang M
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Yan, Xuejiao
AU  - Yan X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Lei, Xiaoyan
AU  - Lei X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Yang, Zhen
AU  - Yang Z
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Shao, Zhirong
AU  - Shao Z
AD  - Department of Graduate, Xi'an Medical University, Xi'an, China.
FAU - Zhang, Xiaoling
AU  - Zhang X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
LA  - eng
PT  - Journal Article
DEP - 20210922
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC8493598
OTO - NOTNLM
OT  - graph theory
OT  - microvascular complications
OT  - resting-state functional magnetic resonance imaging
OT  - small-world
OT  - topological properties
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/10/12 06:00
MHDA- 2021/10/12 06:01
PMCR- 2021/01/01
CRDT- 2021/10/11 05:53
PHST- 2021/06/16 00:00 [received]
PHST- 2021/08/31 00:00 [accepted]
PHST- 2021/10/11 05:53 [entrez]
PHST- 2021/10/12 06:00 [pubmed]
PHST- 2021/10/12 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2021.726350 [doi]
PST - epublish
SO  - Front Neurosci. 2021 Sep 22;15:726350. doi: 10.3389/fnins.2021.726350. 
      eCollection 2021.