PMID- 34630022
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211012
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 15
DP  - 2021
TI  - Aerobic Exercise Attenuates Pain Sensitivity: An Event-Related Potential Study.
PG  - 735470
LID - 10.3389/fnins.2021.735470 [doi]
LID - 735470
AB  - In this study, electroencephalography (EEG) was utilized to explore the 
      neurophysiological mechanisms of aerobic exercise-induced hypoalgesia (EIH) and 
      provide a theoretical basis for the application of aerobic exercise in pain 
      assessment and treatment. Forty-five healthy subjects were randomly divided into 
      moderate-intensity aerobic exercise [70% heart rate reserve (HRR)], low-intensity 
      aerobic exercise (50% HRR), or control groups (sitting). Aerobic exercise was 
      performed with cycling. Pressure pain threshold (PPT), heat pain threshold (HPT), 
      event-related potential (ERP) induced by contact heat stimulus and pain scoring 
      were measured before and after the intervention. We found that moderate-intensity 
      aerobic exercise can increase the PPT (rectus femoris: t = -2.71, p = 0.017; 
      tibialis anterior muscle: t = -2.36, p = 0.033) and HPT (tibialis anterior 
      muscle: t = -2.219, p = 0.044) of proximal intervention sites rather than distal 
      sites, and decreased pain scorings of contact heat stimulus. After 
      moderate-intensity aerobic exercise, alpha oscillation power reflecting the 
      central descending inhibitory function was enhanced (t = -2.31, p < 0.05). 
      Low-intensity aerobic exercise mainly reduced the pain unpleasantness rating 
      (Block 1: t = 2.415, p = 0.030; Block 2: t = 3.287, p = 0.005; Block 4: t = 
      2.646, p = 0.019; Block 5: t = 2.567, p = 0.022). Aerobic exercise had an overall 
      EIH effect. Its hypoalgesic effect was related to exercise intensity and affected 
      by the site and type of pain stimulus. Moderate-intensity aerobic exercise 
      effectively reduced the sensitivity to various painful stimuli, and low-intensity 
      aerobic exercise selectively inhibited the negative emotional pain response. The 
      hypoalgesic mechanism of aerobic exercise involves the enhancement of the central 
      descending inhibitory function.
CI  - Copyright (c) 2021 Zheng, Chen, Yang and Wang.
FAU - Zheng, Kangyong
AU  - Zheng K
AD  - Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, 
      China.
FAU - Chen, Changcheng
AU  - Chen C
AD  - Department of Rehabilitation Medicine, Qingtian People's Hospital, Zhejiang, 
      China.
FAU - Yang, Suyong
AU  - Yang S
AD  - School of Psychology, Shanghai University of Sport, Shanghai, China.
FAU - Wang, Xueqiang
AU  - Wang X
AD  - Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, 
      China.
AD  - Department of Rehabilitation Medicine, Shanghai Shangti Orthopaedic Hospital, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20210921
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC8494006
OTO - NOTNLM
OT  - aerobic exercise
OT  - event-related potential
OT  - exercise intensity
OT  - hypoalgesia
OT  - oscillation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/10/12 06:00
MHDA- 2021/10/12 06:01
PMCR- 2021/01/01
CRDT- 2021/10/11 05:53
PHST- 2021/07/02 00:00 [received]
PHST- 2021/08/27 00:00 [accepted]
PHST- 2021/10/11 05:53 [entrez]
PHST- 2021/10/12 06:00 [pubmed]
PHST- 2021/10/12 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2021.735470 [doi]
PST - epublish
SO  - Front Neurosci. 2021 Sep 21;15:735470. doi: 10.3389/fnins.2021.735470. 
      eCollection 2021.