PMID- 34630300
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211012
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 12
DP  - 2021
TI  - Superficial Macula Capillary Complexity Changes Are Associated With Disability in 
      Neuromyelitis Optica Spectrum Disorders.
PG  - 724946
LID - 10.3389/fneur.2021.724946 [doi]
LID - 724946
AB  - Purpose: We examined the macular microvascular changes of the macula in 
      neuromyelitis optica spectrum disorder (NMOSD) patients and its association with 
      their disability and other clinical variables. Methods: Thirty-four NMOSD (13 
      patients without optic neuritis, NMOSD-NON, and 21 patients with a history of 
      optic neuritis, NMOSD-ON) and 44 healthy controls (HCs) were included in the 
      study. Optical coherence tomographic angiography (OCTA) was used to image the 
      superficial (SCP), deep (DCP), and whole capillary plexus (WCP) in a 
      2.5-mm-diameter concentric circle [excluding the foveal avascular zone (FAZ)]. An 
      algorithm (D(box)) was used to quantify the complexity of the three capillary 
      layers by fractal analysis. We also evaluated the expanded disability scale 
      status (EDSS). Results: D(box) values were significantly reduced in SCP (p < 
      0.001), DCP (p < 0.001), and WCP (p = 0.003) of NMOSD when compared with HCs. 
      D(box) values were significantly reduced in NMOSD eyes with optic neuritis when 
      compared with healthy controls (p < 0.001) and eyes without optic neuritis (p = 
      0.004) in the SCP. In the DCP, eyes with optic neuritis showed significantly 
      reduced D(box) values when compared with eyes without optic neuritis (p = 0.016) 
      and healthy controls (p < 0.001); eyes without optic neuritis showed 
      significantly reduced D(box) values (p = 0.007) in the DCP when compared with 
      healthy controls. A significant negative correlation (Rho = -0.475, p = 0.005) 
      was shown between the superficial macula D(box) values and the EDSS in NMOSD 
      patients. Additionally, a negative correlation (Rho = -0.715, p = 0.006) was seen 
      in the superficial D(box) values in [e]eyes without optic neuritis and EDSS. 
      Conclusions: Macular microvascular damage in the superficial plexus is associated 
      with disability in NMOSD. Macular microvascular alterations arise independently 
      of the occurrence of ON in NMOSD.
CI  - Copyright (c) 2021 Wei, Xie, Wu, He, Meng, Liu, Liang and Zhao.
FAU - Wei, Ruili
AU  - Wei R
AD  - Neurology Department, First Affiliated Hospital, Zhejiang University School of 
      Medicine, Hangzhou, China.
FAU - Xie, Jianyang
AU  - Xie J
AD  - Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials 
      Technology and Engineering, Chinese Academy of Sciences, Ningbo, China.
FAU - Wu, Huihui
AU  - Wu H
AD  - Neurology Department, First Affiliated Hospital, Zhejiang University School of 
      Medicine, Hangzhou, China.
FAU - He, Fangping
AU  - He F
AD  - Neurology Department, First Affiliated Hospital, Zhejiang University School of 
      Medicine, Hangzhou, China.
FAU - Meng, Fangxia
AU  - Meng F
AD  - Neurology Department, First Affiliated Hospital, Zhejiang University School of 
      Medicine, Hangzhou, China.
FAU - Liu, Jiang
AU  - Liu J
AD  - Department of Computer Science and Engineering, Southern University of Science 
      and Technology, Shenzhen, China.
FAU - Liang, Hui
AU  - Liang H
AD  - Neurology Department, First Affiliated Hospital, Zhejiang University School of 
      Medicine, Hangzhou, China.
FAU - Zhao, Yitian
AU  - Zhao Y
AD  - Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials 
      Technology and Engineering, Chinese Academy of Sciences, Ningbo, China.
LA  - eng
PT  - Journal Article
DEP - 20210922
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC8492905
OTO - NOTNLM
OT  - capillaris
OT  - expanded disability status scale
OT  - neuromyelitis optica spectrum disorders
OT  - optic neuritis
OT  - optical coherence tomography angiography
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/10/12 06:00
MHDA- 2021/10/12 06:01
PMCR- 2021/09/22
CRDT- 2021/10/11 05:55
PHST- 2021/06/14 00:00 [received]
PHST- 2021/08/03 00:00 [accepted]
PHST- 2021/10/11 05:55 [entrez]
PHST- 2021/10/12 06:00 [pubmed]
PHST- 2021/10/12 06:01 [medline]
PHST- 2021/09/22 00:00 [pmc-release]
AID - 10.3389/fneur.2021.724946 [doi]
PST - epublish
SO  - Front Neurol. 2021 Sep 22;12:724946. doi: 10.3389/fneur.2021.724946. eCollection 
      2021.