PMID- 34630664
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211012
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Print)
IS  - 1792-0981 (Linking)
VI  - 22
IP  - 5
DP  - 2021 Nov
TI  - HOXC11 positively regulates the long non-coding RNA HOTAIR and is associated with 
      poor prognosis in colon adenocarcinoma.
PG  - 1310
LID - 10.3892/etm.2021.10745 [doi]
LID - 1310
AB  - Colorectal cancer ranks third in terms of incidence and second in terms of 
      mortality worldwide. The homeobox transcript antisense intergenic RNA (HOTAIR), 
      which was found to be located on the antisense chain of the homeobox C (HOXC) 
      gene cluster, is a long non-coding RNA involved in multiple types of tumors. The 
      role of HOXC11 in tumors remains unclear. Reverse transcription-quantitative PCR 
      was performed to detect the expression level of HOXC11 in colon adenocarcinoma. 
      Cell proliferation and invasion were assessed. RNase protection assay was used to 
      test the possibility of RNA duplex formation. The increased expression and 
      co-expression trend of HOXC11 and HOTAIR were identified in multiple types of 
      cancer from The Cancer Genome Atlas and the results were validated in 12 colon 
      adenocarcinoma and paired non-tumor tissue samples. The expression of HOXC11 and 
      HOTAIR was found to be associated with poor prognosis in colon adenocarcinoma and 
      kidney renal clear cell carcinoma. Furthermore, HOXC11 was found to positively 
      regulate HOTAIR by RNA duplex formation and promoted the proliferation and 
      invasion of colon adenocarcinoma cells.
CI  - Copyright: (c) Gong et al.
FAU - Gong, Nana
AU  - Gong N
AD  - Department of Laboratory Medicine, The Fifth Affiliated Hospital of Sun Yat-Sen 
      University, Zhuhai, Guangdong 519000, P.R. China.
FAU - Li, Fei
AU  - Li F
AD  - Department of Pharmacy, The Fifth Affiliated Hospital of Sun Yat-Sen University, 
      Zhuhai, Guangdong 519000, P.R. China.
FAU - Wang, Yanan
AU  - Wang Y
AD  - Department of Laboratory Medicine, The Fifth Affiliated Hospital of Sun Yat-Sen 
      University, Zhuhai, Guangdong 519000, P.R. China.
FAU - Li, Zizi
AU  - Li Z
AD  - Department of Pathology, The Fifth Affiliated Hospital of Sun Yat-Sen University, 
      Zhuhai, Guangdong 519000, P.R. China.
FAU - Wang, Wanqiu
AU  - Wang W
AD  - Department of Laboratory Medicine, The Fifth Affiliated Hospital of Sun Yat-Sen 
      University, Zhuhai, Guangdong 519000, P.R. China.
FAU - Gong, Tingting
AU  - Gong T
AD  - Department of Ultrasound, The Fifth Affiliated Hospital of Sun Yat-Sen 
      University, Zhuhai, Guangdong 519000, P.R. China.
FAU - Meng, Xiaojun
AU  - Meng X
AD  - Department of Endocrinology, The Fifth Affiliated Hospital of Sun Yat-Sen 
      University, Zhuhai, Guangdong 519000, P.R. China.
FAU - Chen, Hongtao
AU  - Chen H
AD  - Department of Laboratory Medicine, The Fifth Affiliated Hospital of Sun Yat-Sen 
      University, Zhuhai, Guangdong 519000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20210916
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC8461627
OTO - NOTNLM
OT  - antisense chain of the homeobox C 11
OT  - colon adenocarcinoma
OT  - homeobox transcript antisense intergenic RNA
OT  - survival
COIS- The authors declare that they have no competing interests.
EDAT- 2021/10/12 06:00
MHDA- 2021/10/12 06:01
PMCR- 2021/09/16
CRDT- 2021/10/11 05:57
PHST- 2020/05/15 00:00 [received]
PHST- 2021/02/22 00:00 [accepted]
PHST- 2021/10/11 05:57 [entrez]
PHST- 2021/10/12 06:00 [pubmed]
PHST- 2021/10/12 06:01 [medline]
PHST- 2021/09/16 00:00 [pmc-release]
AID - ETM-0-0-10745 [pii]
AID - 10.3892/etm.2021.10745 [doi]
PST - ppublish
SO  - Exp Ther Med. 2021 Nov;22(5):1310. doi: 10.3892/etm.2021.10745. Epub 2021 Sep 16.