PMID- 34630960
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220427
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 24
IP  - 6
DP  - 2021 Jun
TI  - Ameliorative effects of crocin on the inflammation and oxidative stress-induced 
      kidney damages by experimental periodontitis in rat.
PG  - 825-832
LID - 10.22038/ijbms.2021.55875.12499 [doi]
AB  - OBJECTIVES: The present study aimed to investigate the effects of periodontitis 
      on kidneys and the protective role of crocin in periodontitis-induced kidney 
      damage. MATERIALS AND METHODS: Ethics committee approval was obtained and 30 
      Wistar rats were randomly divided into 3 groups of 10 rats: Control (C), 
      Periodontitis (P), and Periodontitis + Crocin (P + Cr). After the treatments, rat 
      kidney tissues were incised under anesthesia and blood samples were collected. 
      Biochemical and histopathological analyses were conducted on the samples. 
      RESULTS: Malondialdehyde (MDA), total oxidant status (TOS), and oxidative stress 
      index (OSI) increased in P group rat kidney tissues; urea, creatinine, Tumor 
      necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin 1beta (IL-1beta) 
      levels increased in the serum; glutathione (GSH), superoxide dismutase (SOD), 
      catalase (CAT) and total antioxidant status (TAS) levels were reduced in rat 
      kidney tissues, and renal histopathology deteriorated. In the P + Cr group, we 
      observed improvements in biochemical and histopathological parameters when 
      compared with the P group. CONCLUSION: Periodontitis (P) led to deterioration in 
      oxidative stress parameters and histopathology by increasing the oxidants in 
      kidney tissue. P also led to inflammation in the blood of the rats. Periodontitis 
      + Crocin (P + Cr) administration alleviated the effects of P due to powerful 
      antioxidant anti-inflammatory properties. Cr could be employed as a protective 
      agent in P-induced inflammation and oxidative damage.
FAU - Erdemli, Zeynep
AU  - Erdemli Z
AD  - Inonu University, Faculty of Medicine, Medical Biochemistry Department, Malatya, 
      Turkey.
FAU - Erdemli, Mehmet Erman
AU  - Erdemli ME
AD  - Inonu University, Faculty of Medicine, Medical Biochemistry Department, Malatya, 
      Turkey.
FAU - Gul, Mehmet
AU  - Gul M
AD  - Inonu University, Faculty of Medicine, Histology and Embryology Department, 
      Malatya, Turkey.
FAU - Altinoz, Eyup
AU  - Altinoz E
AD  - Karabuk University, Faculty of Medicine, Medical Biochemistry Department, 
      Karabuk, Turkey.
FAU - Gul, Semir
AU  - Gul S
AD  - Inonu University, Faculty of Medicine, Histology and Embryology Department, 
      Malatya, Turkey.
FAU - Kocaman, Gulhan
AU  - Kocaman G
AD  - Karabuk University, Faculty of Dentistry, Periodontology Department, Karabuk, 
      Turkey.
FAU - Kustepe, Elif Kayhan
AU  - Kustepe EK
AD  - Inonu University, Faculty of Medicine, Histology and Embryology Department, 
      Malatya, Turkey.
FAU - Gozukara Bag, Harika
AU  - Gozukara Bag H
AD  - Inonu University, Faculty of Medicine, Biostatistics Department, Malatya, Turkey.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC8487597
OTO - NOTNLM
OT  - Crocin
OT  - Inflammation
OT  - Kidney damage
OT  - Oxidative stress
OT  - Periodontitis
OT  - Rat
COIS- No potential conflicts of interest were reported by the authors. The authors 
      alone are responsible for the content and authoring of the present paper.
EDAT- 2021/10/12 06:00
MHDA- 2021/10/12 06:01
PMCR- 2021/06/01
CRDT- 2021/10/11 06:00
PHST- 2021/02/23 00:00 [received]
PHST- 2021/04/27 00:00 [accepted]
PHST- 2021/10/11 06:00 [entrez]
PHST- 2021/10/12 06:00 [pubmed]
PHST- 2021/10/12 06:01 [medline]
PHST- 2021/06/01 00:00 [pmc-release]
AID - 10.22038/ijbms.2021.55875.12499 [doi]
PST - ppublish
SO  - Iran J Basic Med Sci. 2021 Jun;24(6):825-832. doi: 
      10.22038/ijbms.2021.55875.12499.