PMID- 34631167
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220427
IS  - 2090-2867 (Print)
IS  - 2090-2875 (Electronic)
IS  - 2090-2867 (Linking)
VI  - 2021
DP  - 2021
TI  - Blood Lactate AUC Is a Sensitive Test for Evaluating the Effect of Exercise 
      Training on Functional Work Capacity in Patients with Chronic Heart Failure.
PG  - 6619747
LID - 10.1155/2021/6619747 [doi]
LID - 6619747
AB  - PURPOSE: Exercise training is an essential treatment option for patients with 
      chronic heart failure (CHF). However, it remains controversial, which surrogate 
      measures of functional work capacity are most reliable. The purpose of this paper 
      was to compare functional capacity work measured as capillary lactate 
      concentrations area under the curve (AUC) with standard cardiopulmonary exercise 
      testing (CPET) with VO(2peak) and the 6-minute walk test (6 MWT). METHODS: 
      Twenty-three patients in New York Heart Association (NYHA) class II/III with left 
      ventricular ejection fraction (LVEF) <35% were randomised to home-based 
      recommendation of regular exercise (RRE) (controls), moderate continuous training 
      (MCT) or aerobic interval training (AIT). The MCT and AIT groups underwent 12 
      weeks of supervised exercise training. Exercise testing was performed as standard 
      CPET treadmill test with analysis of VO(2peak), the 6 MWT and a novel 30-minute 
      submaximal treadmill test with capillary lactate AUC. RESULTS: All patients had 
      statistically significant improvements in VO(2peak), 6 MWT and lactate AUC after 
      12 weeks of exercise training: 6 MWT (p =0.035), VO(2peak) (p =0.049) and lactate 
      AUC (p =0.002). Lactate AUC (p =0.046) and 6MWT (p =0.035), but not VO(2peak) 
      revealed difference between the exercise modalities regarding functional work 
      capacity. CONCLUSION: 6-MWT and lactate AUC, but not VO(2peak), were able to 
      reveal a statistically significant improvement in functional capacity between 
      different exercise modalities.
CI  - Copyright (c) 2021 Torstein Valborgland et al.
FAU - Valborgland, Torstein
AU  - Valborgland T
AUID- ORCID: 0000-0001-6854-7166
AD  - Department of Cardiology, Stavanger University Hospital, Stavanger, Norway.
AD  - Institute of Clinical Science, University of Bergen, Stavanger, Norway.
FAU - Isaksen, Kjetil
AU  - Isaksen K
AD  - Department of Cardiology, Stavanger University Hospital, Stavanger, Norway.
AD  - Institute of Clinical Science, University of Bergen, Stavanger, Norway.
FAU - Munk, Peter Scott
AU  - Munk PS
AD  - Hospital of Southern Norway, Kristiansand, Kristiansand, Norway.
FAU - Larsen, Alf Inge
AU  - Larsen AI
AD  - Department of Cardiology, Stavanger University Hospital, Stavanger, Norway.
AD  - Institute of Clinical Science, University of Bergen, Stavanger, Norway.
LA  - eng
PT  - Journal Article
DEP - 20210930
PL  - United States
TA  - Rehabil Res Pract
JT  - Rehabilitation research and practice
JID - 101566862
PMC - PMC8497121
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2021/10/12 06:00
MHDA- 2021/10/12 06:01
PMCR- 2021/09/30
CRDT- 2021/10/11 06:03
PHST- 2020/12/13 00:00 [received]
PHST- 2021/08/20 00:00 [accepted]
PHST- 2021/10/11 06:03 [entrez]
PHST- 2021/10/12 06:00 [pubmed]
PHST- 2021/10/12 06:01 [medline]
PHST- 2021/09/30 00:00 [pmc-release]
AID - 10.1155/2021/6619747 [doi]
PST - epublish
SO  - Rehabil Res Pract. 2021 Sep 30;2021:6619747. doi: 10.1155/2021/6619747. 
      eCollection 2021.