PMID- 34631927
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240403
IS  - 2328-8957 (Print)
IS  - 2328-8957 (Electronic)
IS  - 2328-8957 (Linking)
VI  - 8
IP  - 8
DP  - 2021 Aug
TI  - ADD It Up: An Evaluation of Antibiotic Duration at Hospital Discharge at a 
      Community Hospital.
PG  - ofab399
LID - 10.1093/ofid/ofab399 [doi]
LID - ofab399
AB  - BACKGROUND: According to the Centers for Disease Control and Prevention, patients 
      admitted to the hospital are commonly discharged on antibiotic therapy with 
      prolonged courses of therapy, which contributes to excessive antibiotic exposure 
      and adverse events. The purpose of this study was to evaluate total antibiotic 
      duration of therapy at hospital discharge at Indiana University Health Arnett, 
      White Memorial, and Frankfort hospitals. METHODS: A multicenter, retrospective 
      electronic health record review was conducted from 1 January to 30 June 2019. 
      Patients were included if they were at least 18 years of age, began antibiotic 
      therapy while admitted, and continued antibiotic therapy at hospital discharge 
      for 1 of the following indications: skin/soft tissue infection (SSTI), urinary 
      tract infection (UTI), community-acquired pneumonia (CAP), or acute exacerbation 
      of chronic obstructive pulmonary disease (AECOPD). The number of days of therapy 
      (DOT) of each inpatient and outpatient antibiotic prescribed was collected to 
      calculate the total DOT, which was utilized to determine the appropriateness of 
      the duration of therapy. RESULTS: Of the 547 patients included, 233 patients 
      (42.6%) had CAP, 120 (21.9%) had UTI, 101 (18.5%) had SSTI, and 93 (17%) had 
      AECOPD. The median duration of antibiotic therapy across all indications was 9 
      days (interquartile range [IQR], 7-11). Median duration for CAP was 9 days (IQR, 
      7-10), AECOPD was 7 days (IQR, 5-9), UTI was 8 days (IQR, 6-10), and SSTI was 12 
      days (IQR, 10-14). CONCLUSIONS: Excess antimicrobial duration at hospital 
      discharge represents an unmet need of antimicrobial stewardship programs.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of 
      Infectious Diseases Society of America.
FAU - Conner, Morgan
AU  - Conner M
AD  - Purdue University College of Pharmacy, West Lafayette, Indiana, USA.
FAU - Harris, William H
AU  - Harris WH
AD  - Purdue University College of Pharmacy, West Lafayette, Indiana, USA.
FAU - Bomkamp, John P
AU  - Bomkamp JP
AD  - Department of Pharmacy, Indiana University Health Arnett Hospital, Lafayette, 
      Indiana, USA.
LA  - eng
PT  - Journal Article
DEP - 20210724
PL  - United States
TA  - Open Forum Infect Dis
JT  - Open forum infectious diseases
JID - 101637045
PMC - PMC8496735
OTO - NOTNLM
OT  - DOT
OT  - antibiotic duration
OT  - antimicrobial stewardship
OT  - days of therapy
OT  - evidence-based medicine
OT  - hospital discharge
OT  - transitions of care
EDAT- 2021/10/12 06:00
MHDA- 2021/10/12 06:01
PMCR- 2021/07/24
CRDT- 2021/10/11 06:10
PHST- 2021/05/11 00:00 [received]
PHST- 2021/07/22 00:00 [accepted]
PHST- 2021/10/11 06:10 [entrez]
PHST- 2021/10/12 06:00 [pubmed]
PHST- 2021/10/12 06:01 [medline]
PHST- 2021/07/24 00:00 [pmc-release]
AID - ofab399 [pii]
AID - 10.1093/ofid/ofab399 [doi]
PST - epublish
SO  - Open Forum Infect Dis. 2021 Jul 24;8(8):ofab399. doi: 10.1093/ofid/ofab399. 
      eCollection 2021 Aug.