PMID- 34632551
OWN - NLM
STAT- MEDLINE
DCOM- 20220310
LR  - 20220311
IS  - 1179-1969 (Electronic)
IS  - 1170-229X (Print)
IS  - 1170-229X (Linking)
VI  - 38
IP  - 11
DP  - 2021 Nov
TI  - Prevalence and Factors Associated with Potential Drug-Drug Interactions in Older 
      Community-Dwelling Adults: A Prospective Cohort Study.
PG  - 1025-1037
LID - 10.1007/s40266-021-00898-8 [doi]
AB  - BACKGROUND: Older patients are at increased risk of drug-drug interactions (DDIs) 
      due to polypharmacy. Cardiovascular and central nervous system (CNS) drugs are 
      commonly implicated in serious DDIs. OBJECTIVES: This study aimed to determine 
      the prevalence and factors associated with potential 'severe' cardiovascular and 
      CNS DDIs among older (>/= 70 years) community-dwellers. METHODS: This was a 
      prospective cohort study using linked data from a national pharmacy claims 
      database and waves 1 and 2 of The Irish LongituDinal study on Ageing (TILDA). 
      'Severe' cardiovascular and CNS DDIs were identified using the British National 
      Formulary 77 and Stockley's Drug Interactions. The prevalence of 'severe' DDIs 
      (any DDI vs. none) was calculated. Logistic regression was used to examine the 
      association between sociodemographic, functional ability, and medication-related 
      factors and the risk of DDI exposure between waves 1 and 2. RESULTS: A total of 
      1466 patients were included [mean age (standard deviation) = 78 (5.5) years; 
      female n = 795, 54.2%]. In total, 332 community-dwellers aged >/= 70 years [22.65%, 
      95% confidence interval (CI) 20.58-24.86] were potentially exposed to at least 
      one 'severe' cardiovascular or CNS DDI, with more than half (54.82%) of this 
      cohort dispensed the same DDI for a prolonged time (>/= 3 consecutive claims). 
      Aspirin-warfarin was the most frequently dispensed (co-prescribed) DDI (n = 34, 
      10.24%, 95% CI 7.39-14.00), followed by atorvastatin-clarithromycin (n = 19, 
      5.72%, 95% CI 3.64-8.81). Polypharmacy [>/= 10 vs. < 5 drugs, odds ratio (OR) 
      13.40, 95% CI 8.22-21.85] and depression (depressed vs. not, OR 2.12, 95% CI 
      1.34-3.34) were significantly associated with these DDIs, after multivariable 
      adjustment. CONCLUSION: 'Severe' cardiovascular and CNS DDIs are prevalent in 
      older community-dwellers in Ireland, and those with polypharmacy and depression 
      are at a significantly increased risk.
CI  - (c) 2021. The Author(s).
FAU - Hughes, John E
AU  - Hughes JE
AUID- ORCID: 0000-0002-3944-8326
AD  - Division of Population Health Sciences, Royal College of Surgeons in Ireland, 
      Dublin, Ireland. johnehughes@rcsi.com.
FAU - Russo, Veronica
AU  - Russo V
AD  - Department of Pharmacy, CIRFF, Center of Pharmacoeconomics, University of Naples 
      Federico II, Naples, Italy.
AD  - Local Health Units (LHU) ROME 1, Rome, Italy.
FAU - Walsh, Caroline
AU  - Walsh C
AD  - Division of Population Health Sciences, Royal College of Surgeons in Ireland, 
      Dublin, Ireland.
FAU - Menditto, Enrica
AU  - Menditto E
AD  - Department of Pharmacy, CIRFF, Center of Pharmacoeconomics, University of Naples 
      Federico II, Naples, Italy.
FAU - Bennett, Kathleen
AU  - Bennett K
AUID- ORCID: 0000-0002-2861-7665
AD  - Division of Population Health Sciences, Royal College of Surgeons in Ireland, 
      Dublin, Ireland.
AD  - Data Science Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.
FAU - Cahir, Caitriona
AU  - Cahir C
AUID- ORCID: 0000-0002-7137-5737
AD  - Division of Population Health Sciences, Royal College of Surgeons in Ireland, 
      Dublin, Ireland.
AD  - Data Science Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.
LA  - eng
GR  - EP-C-17-015/EPA/EPA/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211011
PL  - New Zealand
TA  - Drugs Aging
JT  - Drugs & aging
JID - 9102074
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - Drug Interactions
MH  - Female
MH  - Humans
MH  - *Independent Living
MH  - Longitudinal Studies
MH  - Male
MH  - *Polypharmacy
MH  - Prevalence
MH  - Prospective Studies
PMC - PMC8594274
COIS- None to declare.
EDAT- 2021/10/12 06:00
MHDA- 2022/03/11 06:00
PMCR- 2021/10/11
CRDT- 2021/10/11 06:24
PHST- 2021/09/23 00:00 [accepted]
PHST- 2021/10/12 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2021/10/11 06:24 [entrez]
PHST- 2021/10/11 00:00 [pmc-release]
AID - 10.1007/s40266-021-00898-8 [pii]
AID - 898 [pii]
AID - 10.1007/s40266-021-00898-8 [doi]
PST - ppublish
SO  - Drugs Aging. 2021 Nov;38(11):1025-1037. doi: 10.1007/s40266-021-00898-8. Epub 
      2021 Oct 11.