PMID- 34633393
OWN - NLM
STAT- MEDLINE
DCOM- 20211110
LR  - 20211110
IS  - 1364-5528 (Electronic)
IS  - 0003-2654 (Linking)
VI  - 146
IP  - 22
DP  - 2021 Nov 8
TI  - A paper-based sensor for rapid and ultrasensitive detection of ibuprofen in water 
      and herbal tea.
PG  - 6874-6882
LID - 10.1039/d1an01533h [doi]
AB  - As the use of non-steroidal anti-inflammatory drugs (NSAIDS) increases, their 
      side effects have also attracted attention. Ibuprofen is one of the most 
      widely-used NSAIDs. In this study, we screened the highly-sensitive and specific 
      antibody 6E10, with an IC(50) of 1.92 ng mL(-1), and a linear range of 0.53-6.97 
      ng mL(-1). In this study, we developed a rapid lateral flow immunochromatographic 
      assay (ICA) strip method to detect ibuprofen in water or herbal tea. The cut-off 
      limit of the strip is 10 ng mL(-1) in water, and concentrations as low as 1 ng 
      mL(-1) can be detected in herbal tea samples, with the results obtained by the 
      naked eye within 6 min. All the data were confirmed by high performance liquid 
      chromatography-quadrupole time of flight-mass spectrometry (HPLC-QTOF-MS). This 
      lateral-flow ICA strip is thus a rapid tool for on-site detection and screening 
      of ibuprofen in water and herbal tea.
FAU - Li, Shaozhen
AU  - Li S
AD  - State Key Lab of Food Science and Technology, School of Food Science and 
      Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of 
      China. xcl@jiangnan.edu.cn.
FAU - Ge, Wenliang
AU  - Ge W
AD  - Wuxi No. 2 People's Hospital, Wuxi, 214002, Jiangsu, People's Republic of China. 
      2324999898@qq.com.
FAU - Suryoprabowo, Steven
AU  - Suryoprabowo S
AD  - State Key Lab of Food Science and Technology, School of Food Science and 
      Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of 
      China. xcl@jiangnan.edu.cn.
FAU - Liu, Jie
AU  - Liu J
AD  - State Key Lab of Food Science and Technology, School of Food Science and 
      Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of 
      China. xcl@jiangnan.edu.cn.
FAU - Kuang, Hua
AU  - Kuang H
AUID- ORCID: 0000-0002-2724-8722
AD  - State Key Lab of Food Science and Technology, School of Food Science and 
      Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of 
      China. xcl@jiangnan.edu.cn.
FAU - Zhu, Jianping
AU  - Zhu J
AD  - State Key Lab of Food Science and Technology, School of Food Science and 
      Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of 
      China. xcl@jiangnan.edu.cn.
FAU - Liu, Liqiang
AU  - Liu L
AD  - State Key Lab of Food Science and Technology, School of Food Science and 
      Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of 
      China. xcl@jiangnan.edu.cn.
FAU - Xu, Chuanlai
AU  - Xu C
AUID- ORCID: 0000-0002-5639-7102
AD  - State Key Lab of Food Science and Technology, School of Food Science and 
      Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of 
      China. xcl@jiangnan.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20211108
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
RN  - 0 (Teas, Herbal)
RN  - 059QF0KO0R (Water)
RN  - WK2XYI10QM (Ibuprofen)
SB  - IM
MH  - Chromatography, Affinity
MH  - *Ibuprofen
MH  - Limit of Detection
MH  - *Teas, Herbal
MH  - Water
EDAT- 2021/10/12 06:00
MHDA- 2021/11/11 06:00
CRDT- 2021/10/11 12:22
PHST- 2021/10/12 06:00 [pubmed]
PHST- 2021/11/11 06:00 [medline]
PHST- 2021/10/11 12:22 [entrez]
AID - 10.1039/d1an01533h [doi]
PST - epublish
SO  - Analyst. 2021 Nov 8;146(22):6874-6882. doi: 10.1039/d1an01533h.