PMID- 34634624
OWN - NLM
STAT- MEDLINE
DCOM- 20211216
LR  - 20230202
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 56
DP  - 2021 Nov
TI  - Retinal microvascular and neuronal function in patients with multiple sclerosis: 
      2-year follow-up.
PG  - 103314
LID - S2211-0348(21)00581-2 [pii]
LID - 10.1016/j.msard.2021.103314 [doi]
AB  - OBJECTIVE: To determine the longitudinal changes in retinal microstructure, 
      microvasculature, microcirculation, and axonal and neuronal functions in patients 
      with relapsing-remitting multiple sclerosis (RRMS) over the time course of about 
      two years. METHODS: A total of 30 patients (60 eyes) with RRMS were followed for 
      a period of 27 +/- 6 months and evaluated with a battery of clinical tests 
      including low contrast letter acuity (LCLA), intraretinal layer thicknesses by 
      optical coherence tomography (OCT), ganglion cell function by steady-state 
      pattern electroretinography (PERG), axonal function by polarization-sensitive 
      OCT, volumetric vessel density (VVD) by OCT angiography, and retinal tissue 
      perfusion (RTP) by retinal function imager. RESULTS: Axonal function measured as 
      retinal nerve fiber layer birefringence in the temporal quadrant and vessel 
      density in the deep vascular plexus were significantly decreased at 2-year 
      follow-up (P < 0.05). Subgroup analyses showed that the increased retinal blood 
      flow volume occurred in patients with no evidence of disease activity (NEDA), and 
      with stable or improved visual function (P < 0.05). There was no significant 
      difference in the expanded disability state scale, LCLA, RTP, VVD, or PERG 
      measures between the two visits (P > 0.05). CONCLUSION: To our best knowledge, 
      this is the first 2-year prospective comprehensive study with a detailed 
      assessment of retinal microstructure and neuronal functions in patients with 
      RRMS. The recovery of retinal microcirculation occurred in patients with NEDA, 
      and stable or improved visual function, suggesting these measurements as 
      potential imaging biomarkers for monitoring disease progression.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Chen, Qi
AU  - Chen Q
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China; Department of Ophthalmology, Bascom Palmer Eye Institute, 
      University of Miami Miller School of Medicine, Miami, FL, United States.
FAU - Fang, Min
AU  - Fang M
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, FL, United States; Shenzhen Key Laboratory of 
      Ophthalmology, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
FAU - Miri, Shahnaz
AU  - Miri S
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, FL, United States.
FAU - Thakor, Kinjal
AU  - Thakor K
AD  - Department of Neurology, University of Miami Miller School of Medicine, Miami, 
      FL, United States.
FAU - Delgado, Silvia
AU  - Delgado S
AD  - Department of Neurology, University of Miami Miller School of Medicine, Miami, 
      FL, United States.
FAU - Hernandez, Jeffrey
AU  - Hernandez J
AD  - Department of Neurology, University of Miami Miller School of Medicine, Miami, 
      FL, United States.
FAU - Alba, Diego Eduardo
AU  - Alba DE
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, FL, United States.
FAU - Gregori, Giovanni
AU  - Gregori G
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, FL, United States.
FAU - Porciatti, Vittorio
AU  - Porciatti V
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, FL, United States.
FAU - Wang, Jianhua
AU  - Wang J
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, FL, United States.
FAU - Jiang, Hong
AU  - Jiang H
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, FL, United States; Department of Neurology, 
      University of Miami Miller School of Medicine, Miami, FL, United States. 
      Electronic address: h.jiang@med.miami.edu.
LA  - eng
GR  - P30 EY014801/EY/NEI NIH HHS/United States
PT  - Journal Article
DEP - 20211004
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
SB  - IM
MH  - Follow-Up Studies
MH  - Humans
MH  - *Multiple Sclerosis/diagnostic imaging
MH  - *Multiple Sclerosis, Relapsing-Remitting
MH  - Prospective Studies
MH  - Retina/diagnostic imaging
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - Birefringence
OT  - Multiple sclerosis
OT  - Retinal microstructure
OT  - Retinal microvasculature
OT  - Retinal nerve fiber layer
EDAT- 2021/10/12 06:00
MHDA- 2021/12/17 06:00
CRDT- 2021/10/11 20:23
PHST- 2021/02/25 00:00 [received]
PHST- 2021/09/11 00:00 [revised]
PHST- 2021/10/03 00:00 [accepted]
PHST- 2021/10/12 06:00 [pubmed]
PHST- 2021/12/17 06:00 [medline]
PHST- 2021/10/11 20:23 [entrez]
AID - S2211-0348(21)00581-2 [pii]
AID - 10.1016/j.msard.2021.103314 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2021 Nov;56:103314. doi: 10.1016/j.msard.2021.103314. 
      Epub 2021 Oct 4.