PMID- 34636744
OWN - NLM
STAT- MEDLINE
DCOM- 20211224
LR  - 20220520
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 185
IP  - 6
DP  - 2021 Nov 26
TI  - Pituitary adenoma in patients with multiple endocrine neoplasia type 1: a cohort 
      study.
PG  - 863-873
LID - 10.1530/EJE-21-0630 [doi]
AB  - OBJECTIVE: Pituitary adenoma (PA) is one of the three major components of 
      multiple endocrine neoplasia type 1 (MEN1). Recent studies have suggested that 
      MEN1-associated PAs are less aggressive than initially estimated. We propose an 
      analysis of the outcome of PAs with a standard of care treatment in a nationwide 
      cohort of MEN1 patients. DESIGN: Retrospective observational nationwide cohort 
      study using the MEN1 patient registry from the French Group of Endocrine Tumours 
      (GTE). METHODS: The GTE database population consists of 1435 patients with MEN1. 
      This analysis focused on 551 patients recruited after 2000 with at least 3 years 
      of follow-up. The study outcome was tumour progression of PA defined by an 
      increase in Hardy classification (HC) during follow-up according to referring 
      physician regular reports. RESULTS: Among 551 MEN1 patients (index and related), 
      202 (36.7%) had PA, with 114 (56.4%) diagnosed by MEN1-related screening. PAs 
      were defined according to HC as microadenoma (grade I) in 117 cases (57.9%), 
      macroadenoma in 59 (29.2%) with 20 HC grade II and 39 HC grades III-IV and 
      unspecified in 26 (12.8%). They were prolactinomas in 92 cases (45.5%) and 
      non-secreting in 73 (36.1%). After a median follow-up of 3 years among the 137 
      patients with HC grades I-II, 4 patients (2.9%) presented tumour progression. 
      CONCLUSION: PAs in patients with MEN1 are less aggressive than previously 
      thought. Tumour progression is rare with a standard of care monitoring and 
      treatment, especially in related patients who mostly present non-secreting 
      microadenoma. MRI monitoring for asymptomatic MEN1 patients should be reduced 
      accordingly.
FAU - Le Bras, Maelle
AU  - Le Bras M
AUID- ORCID: 0000-0001-8097-3862
AD  - CHU de Nantes PHU2 Institut du Thorax et du Systeme Nerveux, Service 
      d'Endocrinologie, Diabetologie et Nutrition, Nantes, France.
FAU - Leclerc, Helene
AU  - Leclerc H
AD  - Centre Hospitalier de La Roche sur Yon, Department of Endocrinology and 
      Diabetology, La Roche sur Yon, France.
FAU - Rousseau, Olivia
AU  - Rousseau O
AD  - INSERM CIC 1413, Clinique des Donnees, CHU de Nantes, Nantes, France.
FAU - Goudet, Pierre
AU  - Goudet P
AD  - University Hospital Dijon, Endocrine Surgery, Hopital du Bocage, Dijon, France.
FAU - Cuny, Thomas
AU  - Cuny T
AD  - Department of Endocrinology, Hopital de la Conception, Marseille, France.
FAU - Castinetti, Frederic
AU  - Castinetti F
AUID- ORCID: 0000-0002-1808-8800
AD  - Aix-Marseille Universite, Assistance-Publique-Hopitaux de Marseille, Centre de 
      Reference des Maladies Rares d'Origine Hypophysaire, Department of endocrinology, 
      Marseille, France.
FAU - Bauters, Catherine
AU  - Bauters C
AD  - CHU Lille, Service d'Endocrinologie, Lille, France.
FAU - Chanson, Philippe
AU  - Chanson P
AUID- ORCID: 0000-0001-5096-5722
AD  - Assistance Publique-Hopitaux de Paris, Endocrinology, Le Kremlin-Bicetre, 
      Ile-de-France, France.
FAU - Tabarin, Antoine
AU  - Tabarin A
AD  - Department of Endocrinology, Hopital Haut Leveque-CHU de Bordeaux, Pessac, 
      France.
FAU - Gaujoux, Sebastien
AU  - Gaujoux S
AD  - Hopital Cochin, Digestive and Endocrine Surgery, Paris, France.
FAU - Christin-Maitre, Sophie
AU  - Christin-Maitre S
AD  - Hopital Saint-Antoine, Endocrine Unit, Paris, France.
FAU - Ruszniewski, Philippe
AU  - Ruszniewski P
AD  - Department of Gastroenterology and Pancreatology, Universite Paris Diderot, 
      Sorbonne Paris Cite, Beaujon Hospital, Paris Clichy, France.
FAU - Borson-Chazot, Francoise
AU  - Borson-Chazot F
AD  - Hospices Civils de Lyon, Federation d'Endocrinologie Groupement Hospitalier Est, 
      Lyon, France.
FAU - Guilhem, Isabelle
AU  - Guilhem I
AD  - Centre Hospitalier Universitaire de Rennes, Hopital Sud, Service 
      d'Endocrinologie-Diabetologie-Nutrition, Rennes, France.
FAU - Caron, Philippe
AU  - Caron P
AD  - CHU Toulouse, Endocrinology and Metabolic diseases, Service d'Endocrinologie, 
      Toulouse, France.
FAU - Goichot, Bernard
AU  - Goichot B
AD  - Hopital de Hautepierre, Service de Medecine Interne et Nutrition, Strasbourg 
      Cedex, France.
FAU - Beckers, Albert
AU  - Beckers A
AD  - CHU de Liege, Service d'Endocrinologie, Domaine Univeritaire du Sart-Tilman, 
      Liege, Belgium.
FAU - Delemer, Brigitte
AU  - Delemer B
AD  - Hopital Robert-Debre, CHU de Reims, Service Endocrinologie, Reims, France.
FAU - Raingeard, Isabelle
AU  - Raingeard I
AD  - University Hospital of Montpellier, Endocrinology, Montpellier, France.
FAU - Verges, Bruno
AU  - Verges B
AD  - CHU Dijon, Hopital du Bocage, Endocrinologie, Diabetologie, Dijon, France.
FAU - Smati, Sarra
AU  - Smati S
AD  - CHU de Nantes PHU2 Institut du Thorax et du Systeme Nerveux, Service 
      d'Endocrinologie, Diabetologie et Nutrition, Nantes, France.
AD  - UNIV Nantes, CNRS, INSERM, CHU Nantes, l'Institut du Thorax, Nantes, France.
FAU - Wargny, Matthieu
AU  - Wargny M
AD  - CHU de Nantes PHU2 Institut du Thorax et du Systeme Nerveux, Service 
      d'Endocrinologie, Diabetologie et Nutrition, Nantes, France.
AD  - UNIV Nantes, CNRS, INSERM, CHU Nantes, l'Institut du Thorax, Nantes, France.
FAU - Cariou, Bertrand
AU  - Cariou B
AD  - CHU de Nantes PHU2 Institut du Thorax et du Systeme Nerveux, Service 
      d'Endocrinologie, Diabetologie et Nutrition, Nantes, France.
AD  - UNIV Nantes, CNRS, INSERM, CHU Nantes, l'Institut du Thorax, Nantes, France.
FAU - Hadjadj, Samy
AU  - Hadjadj S
AD  - CHU de Nantes PHU2 Institut du Thorax et du Systeme Nerveux, Service 
      d'Endocrinologie, Diabetologie et Nutrition, Nantes, France.
AD  - UNIV Nantes, CNRS, INSERM, CHU Nantes, l'Institut du Thorax, Nantes, France.
LA  - eng
PT  - Journal Article
DEP - 20211126
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*pathology
MH  - Pituitary Neoplasms/*pathology
MH  - Retrospective Studies
EDAT- 2021/10/13 06:00
MHDA- 2021/12/25 06:00
CRDT- 2021/10/12 12:49
PHST- 2021/06/14 00:00 [received]
PHST- 2021/10/07 00:00 [accepted]
PHST- 2021/10/13 06:00 [pubmed]
PHST- 2021/12/25 06:00 [medline]
PHST- 2021/10/12 12:49 [entrez]
AID - 10.1530/EJE-21-0630 [doi]
PST - epublish
SO  - Eur J Endocrinol. 2021 Nov 26;185(6):863-873. doi: 10.1530/EJE-21-0630.