PMID- 34636791
OWN - NLM
STAT- MEDLINE
DCOM- 20211126
LR  - 20230826
IS  - 1473-6500 (Electronic)
IS  - 0952-7907 (Linking)
VI  - 34
IP  - 6
DP  - 2021 Dec 1
TI  - Demystifying alpha-gal syndrome: identification and risk management in the 
      perioperative setting.
PG  - 761-765
LID - 10.1097/ACO.0000000000001066 [doi]
AB  - PURPOSE OF REVIEW: alpha-Gal syndrome is among a vexing perioperative consideration 
      for anesthesiologists. Commonly referred to as 'red meat allergy', alpha-Gal syndrome 
      is precipitated by a lone star tick bite resulting in the formation of 
      immunoglobulin E (IgE) antibodies against the tick salivary glycoproteins and 
      noncatarrhine mammalian tissue. RECENT FINDINGS: Up to 20% of the population in 
      the southeastern United States may test positive for IgE antibodies to alpha-Gal. 
      Increasingly, recognition of alpha-Gal syndrome as an immune response to red meat 
      consumption and certain drugs, many of which may be administered within the 
      perioperative period, has led to greater awareness of the insidious nature of its 
      presentation - from mild urticaria and gastrointestinal symptoms to severe 
      anaphylaxis. SUMMARY: With the increasing prevalence and identification of alpha-Gal 
      syndrome, a safe and tailored perioperative process is needed to integrate a 
      pathway that involves multidisciplinary communication, robust information sharing 
      platform, and a structured peri-procedure management.
CI  - Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Wolaver, Whitney
AU  - Wolaver W
AD  - Department of Anesthesiology, Virginia Commonwealth University Health System, 
      Richmond, Virginia.
FAU - Thakrar, Shilen
AU  - Thakrar S
AD  - Department of Anesthesiology, Virginia Commonwealth University Health System, 
      Richmond, Virginia.
FAU - Thomas, Kelvin
AU  - Thomas K
AD  - Department of Anesthesiology, Virginia Commonwealth University Health System, 
      Richmond, Virginia.
FAU - Thakrar, Hiral
AU  - Thakrar H
AD  - Department of Allergy and Immunology, Scripps Health Carmel Valley, San Diego, 
      California.
FAU - Schwartz, Lawrence
AU  - Schwartz L
AD  - Department of Internal Medicine.
FAU - Zuelzer, Wilhelm
AU  - Zuelzer W
AD  - Department of Orthopedic Surgery.
FAU - Butterworth, John 4th
AU  - Butterworth J 4th
AD  - Department of Anesthesiology, Virginia Commonwealth University Health System, 
      Richmond, Virginia.
FAU - Hoelting, Kyle
AU  - Hoelting K
AD  - Department of Pharmacy Services, Virginia Commonwealth University Health System, 
      Richmond, Virginia, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Anaesthesiol
JT  - Current opinion in anaesthesiology
JID - 8813436
RN  - 37341-29-0 (Immunoglobulin E)
RN  - red meat allergy
SB  - IM
MH  - Animals
MH  - *Food Hypersensitivity/diagnosis/epidemiology
MH  - Humans
MH  - Immunoglobulin E
MH  - Risk Management
MH  - *Tick Bites
EDAT- 2021/10/13 06:00
MHDA- 2021/11/27 06:00
CRDT- 2021/10/12 12:50
PHST- 2021/10/13 06:00 [pubmed]
PHST- 2021/11/27 06:00 [medline]
PHST- 2021/10/12 12:50 [entrez]
AID - 00001503-202112000-00016 [pii]
AID - 10.1097/ACO.0000000000001066 [doi]
PST - ppublish
SO  - Curr Opin Anaesthesiol. 2021 Dec 1;34(6):761-765. doi: 
      10.1097/ACO.0000000000001066.