PMID- 34637171
OWN - NLM
STAT- MEDLINE
DCOM- 20211231
LR  - 20220531
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 75
IP  - 12
DP  - 2021 Dec
TI  - Paraoxonase 1 (PON1) L55M and Q192R polymorphisms are not associated with chronic 
      kidney disease in Thai individuals with type 2 diabetes.
PG  - e14982
LID - 10.1111/ijcp.14982 [doi]
AB  - BACKGROUND: Decreased paraoxonase 1 (PON1) activity and PON1 polymorphisms have 
      been found to be associated with chronic kidney disease (CKD) in type 2 diabetes 
      mellitus (T2DM). OBJECTIVE: This study aimed to investigate the association of 
      the PON1 L55M and Q192R polymorphisms with CKD in T2DM, as well as their 
      relationship with PON1 activity. METHODS: A total of 166 T2DM patients, including 
      83 CKD patients and 83 non-CKD patients, were recruited. Biochemical parameters 
      and paraoxonase (PONase) and arylesterase (AREase) activities were measured. The 
      PON1 L55M and Q192R polymorphisms were analysed by a polymerase chain reaction 
      and restriction fragment length polymorphism (PCR-RFLP) method. Data were 
      analysed using the chi-square test, Student's t-test and logistic regression 
      analysis. RESULTS: Total cholesterol, TGs, LDL-C and Cr were significantly higher 
      in CKD patients than in non-CKD patients. In contrast, the estimated glomerular 
      filtration rate (eGFR) and AREase activity were significantly lower in CKD 
      patients than in non-CKD patients (P < .05). The genotype and allele frequencies 
      of the PON1 L55M and Q192R polymorphisms were not significantly different between 
      CKD and non-CKD patients. Multivariate logistic regression analysis showed no 
      association between the PON1 L55M and Q192R polymorphisms and CKD in T2DM. In 
      addition, among all patients, patients with the PON1 LM genotype had 
      significantly lower PONase activity than those with the LL genotype (P < .05). 
      Among all patients, CKD patients and non-CKD patients, those with the PON1 RR 
      genotype had significantly higher PONase activity but lower AREase activity than 
      patients with the QR and QQ genotypes (P < .05). CONCLUSIONS: PON1 activity was 
      influenced by the PON1 L55M and Q192R polymorphisms. However, the PON1 L55M and 
      Q192R polymorphisms may not be considered genetic biomarkers for CKD in T2DM.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Nawaka, Nantiya
AU  - Nawaka N
AD  - School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 
      Thailand.
FAU - Pansang, Pornprapa
AU  - Pansang P
AD  - School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 
      Thailand.
FAU - Saniwa, Afifah
AU  - Saniwa A
AD  - School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 
      Thailand.
FAU - Chaibut, Nathanai
AU  - Chaibut N
AD  - School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 
      Thailand.
FAU - Jeenduang, Nutjaree
AU  - Jeenduang N
AD  - School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 
      Thailand.
AD  - Food Technology and Innovation Research Center of Excellence, Walailak 
      University, Nakhon Si Thammarat, Thailand.
LA  - eng
GR  - WU-IRG-62-020/This work was supported by Walailak University fund/
PT  - Journal Article
DEP - 20211020
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
RN  - EC 3.1.8.1 (PON1 protein, human)
SB  - IM
MH  - Aryldialkylphosphatase/genetics
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - Genotype
MH  - Humans
MH  - Polymorphism, Genetic/genetics
MH  - *Renal Insufficiency, Chronic/genetics
MH  - Thailand
EDAT- 2021/10/13 06:00
MHDA- 2022/01/01 06:00
CRDT- 2021/10/12 13:07
PHST- 2021/07/23 00:00 [received]
PHST- 2021/10/10 00:00 [accepted]
PHST- 2021/10/13 06:00 [pubmed]
PHST- 2022/01/01 06:00 [medline]
PHST- 2021/10/12 13:07 [entrez]
AID - 10.1111/ijcp.14982 [doi]
PST - ppublish
SO  - Int J Clin Pract. 2021 Dec;75(12):e14982. doi: 10.1111/ijcp.14982. Epub 2021 Oct 
      20.