PMID- 34637605
OWN - NLM
STAT- MEDLINE
DCOM- 20211221
LR  - 20220531
IS  - 2050-4527 (Electronic)
IS  - 2050-4527 (Linking)
VI  - 10
IP  - 1
DP  - 2022 Jan
TI  - Association of HLA class I and II genes with Middle East respiratory syndrome 
      coronavirus infection in Koreans.
PG  - 111-116
LID - 10.1002/iid3.541 [doi]
AB  - INTRODUCTION: Middle East Respiratory Syndrome (MERS) caused by MERS-coronavirus 
      (CoV) is a lower respiratory tract disease characterized by a high mortality 
      rate. MERS-CoV spread from Saudi Arabia to other countries, including South 
      Korea. Dysfunction of the human leukocyte antigen (HLA) system has many effects 
      due to genetic complexity and its role in the adaptive immune response. We 
      investigated the association of HLA class I and II alleles with MERS-CoV in 32 
      patients with MERS. METHODS: HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 were 
      genotyped by polymerase chain reaction sequence-based typing. RESULTS: 
      HLA-DQB1*03:02 are significantly associated with moderate/mild cases of MERS-CoV. 
      Other alleles are no statistical significance. CONCLUSIONS: Treatment strategies 
      based on current research on the HLA gene and MERS-CoV will provide potential 
      therapeutic targets.
CI  - (c) 2021 The Authors. Immunity, Inflammation and Disease published by John Wiley & 
      Sons Ltd.
FAU - Baek, In-Cheol
AU  - Baek IC
AUID- ORCID: 0000-0003-3630-3364
AD  - Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of 
      Korea, Seoul, Korea.
FAU - Choi, Eun-Jeong
AU  - Choi EJ
AUID- ORCID: 0000-0001-7283-7887
AD  - Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of 
      Korea, Seoul, Korea.
FAU - Shin, Dong-Hwan
AU  - Shin DH
AUID- ORCID: 0000-0002-4618-6651
AD  - Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of 
      Korea, Seoul, Korea.
FAU - Kim, Hyoung-Jae
AU  - Kim HJ
AUID- ORCID: 0000-0002-1407-6845
AD  - Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of 
      Korea, Seoul, Korea.
FAU - Choi, Haeyoun
AU  - Choi H
AUID- ORCID: 0000-0002-3406-4438
AD  - Department of Microbiology, College of Medicine, The Catholic University of 
      Korea, Seoul, Korea.
FAU - Shin, Hyoung-Shik
AU  - Shin HS
AUID- ORCID: 0000-0001-6504-3413
AD  - Department of Infectious Diseases, College of Medicine, Eulji University, 
      Daejeon, Seogu, Korea.
FAU - Lim, Dong-Gyun
AU  - Lim DG
AUID- ORCID: 0000-0002-8291-1873
AD  - Translational Research Center, Research Institute of Public Health, National 
      Medical Center, Seoul, Korea.
FAU - Kim, Tai-Gyu
AU  - Kim TG
AUID- ORCID: 0000-0002-2226-2138
AD  - Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of 
      Korea, Seoul, Korea.
AD  - Department of Microbiology, College of Medicine, The Catholic University of 
      Korea, Seoul, Korea.
LA  - eng
GR  - 2019R1I1A1A01064049/Basic Science Research Program through the National Research 
      Foundation of Korea (NRF) funded by the Ministry of Education 
      (2019R1I1A1A01064049)/
GR  - NMC2018-MS-01/National Medical Center of the Republic of Korea (NMC2018-MS-01)/
GR  - HI14C3417/Korean Health Technology R&D Project of the Ministry for Health 
      & Welfare of the Republic of Korea (HI14C3417)/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211012
PL  - England
TA  - Immun Inflamm Dis
JT  - Immunity, inflammation and disease
JID - 101635460
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - *Genes, MHC Class I
MH  - *Genes, MHC Class II
MH  - HLA-DQ beta-Chains/genetics
MH  - Humans
MH  - *Middle East Respiratory Syndrome Coronavirus/genetics
MH  - Republic of Korea
PMC - PMC8669699
OTO - NOTNLM
OT  - HLA
OT  - MERS
OT  - MERS-CoV
OT  - Middle East respiratory syndrome coronavirus
COIS- The authors declare that there are no conflict of interests.
EDAT- 2021/10/13 06:00
MHDA- 2021/12/22 06:00
PMCR- 2021/10/12
CRDT- 2021/10/12 17:28
PHST- 2021/09/13 00:00 [revised]
PHST- 2021/08/08 00:00 [received]
PHST- 2021/09/15 00:00 [accepted]
PHST- 2021/10/13 06:00 [pubmed]
PHST- 2021/12/22 06:00 [medline]
PHST- 2021/10/12 17:28 [entrez]
PHST- 2021/10/12 00:00 [pmc-release]
AID - IID3541 [pii]
AID - 10.1002/iid3.541 [doi]
PST - ppublish
SO  - Immun Inflamm Dis. 2022 Jan;10(1):111-116. doi: 10.1002/iid3.541. Epub 2021 Oct 
      12.