PMID- 34638088
OWN - NLM
STAT- MEDLINE
DCOM- 20211101
LR  - 20211204
IS  - 1879-1514 (Electronic)
IS  - 0166-445X (Linking)
VI  - 240
DP  - 2021 Nov
TI  - Zinc antagonizes common carp (Cyprinus carpio) intestinal arsenic poisoning 
      through PI3K/AKT/mTOR signaling cascade and MAPK pathway.
PG  - 105986
LID - S0166-445X(21)00245-9 [pii]
LID - 10.1016/j.aquatox.2021.105986 [doi]
AB  - Arsenic (As) pollution is a serious and longstanding problem, which has obvious 
      threaten to aquatic organisms. The study aimed to explore the mitigation effect 
      of natural antioxidant zinc (Zn) on As toxicity in the foregut and midgut of 
      common carp (Cyprinus carpio L.), and in-depth disclose related signal cascade. 
      Carps were treated with Zn(2+) (1 mg/L) and/or As(3+) (2.83 mg/L) for a period of 
      30 days. Under As exposure, the foregut and midgut showed obvious burst of 
      reactive oxygen species (ROS) and breakdown of antioxidant system. What followed 
      is the activation of the endogenous and exogenous apoptotic pathways, and the 
      rise of autophagy level prompted by the increase in LC3 II and the 
      down-regulation of p62. Mitochondrial swelling, cristae fragmentation and 
      autophagosomes were observed under the electron microscope, which also means the 
      occurrence of apoptosis and autophagy. In addition, As induced the activation of 
      p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK) and 
      the inhibition of extracellular signal-related kinase (ERK) in MAPK signaling, 
      and up-regulated the level of autophagy through the inhibition of the 
      phosphatidylinositol 3 kinase (PI3K)/AKT/ mammalian target of rapamycin (mTOR) 
      signaling cascade. However, Zn supplementation has clearly reversed the above 
      phenomenon, and it basically has no effect on foregut and midgut. In conclusion, 
      this study shows that Zn can alleviate the damage caused by subchronic As 
      exposure, which provides a reference for the use of Zn preparations in 
      aquaculture.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Guo, Menghao
AU  - Guo M
AD  - College of Wildlife and Protected Area, Northeast Forestry University, Harbin 
      150040, Heilongjiang, PR China.
FAU - Wang, Yu
AU  - Wang Y
AD  - College of Wildlife and Protected Area, Northeast Forestry University, Harbin 
      150040, Heilongjiang, PR China.
FAU - Zhao, Hongjing
AU  - Zhao H
AD  - College of Wildlife and Protected Area, Northeast Forestry University, Harbin 
      150040, Heilongjiang, PR China.
FAU - Wang, Dongxu
AU  - Wang D
AD  - College of Wildlife and Protected Area, Northeast Forestry University, Harbin 
      150040, Heilongjiang, PR China.
FAU - Yin, Kai
AU  - Yin K
AD  - College of Wildlife and Protected Area, Northeast Forestry University, Harbin 
      150040, Heilongjiang, PR China.
FAU - Liu, Yachen
AU  - Liu Y
AD  - College of Wildlife and Protected Area, Northeast Forestry University, Harbin 
      150040, Heilongjiang, PR China.
FAU - Li, Baoying
AU  - Li B
AD  - College of Wildlife and Protected Area, Northeast Forestry University, Harbin 
      150040, Heilongjiang, PR China.
FAU - Xing, Mingwei
AU  - Xing M
AD  - College of Wildlife and Protected Area, Northeast Forestry University, Harbin 
      150040, Heilongjiang, PR China. Electronic address: xingmingwei@nefu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20211005
PL  - Netherlands
TA  - Aquat Toxicol
JT  - Aquatic toxicology (Amsterdam, Netherlands)
JID - 8500246
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Water Pollutants, Chemical)
RN  - EC 2.7.1.137 (Phosphatidylinositol 3-Kinase)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - *Arsenic Poisoning
MH  - *Carps
MH  - Extracellular Signal-Regulated MAP Kinases
MH  - Phosphatidylinositol 3-Kinase
MH  - Phosphatidylinositol 3-Kinases
MH  - Proto-Oncogene Proteins c-akt
MH  - Reactive Oxygen Species
MH  - TOR Serine-Threonine Kinases
MH  - *Water Pollutants, Chemical/toxicity
MH  - Zinc
OTO - NOTNLM
OT  - Antagonist
OT  - Apoptosis
OT  - Aquatic environment
OT  - Autophagy
OT  - Carp
OT  - Oxidative stress
EDAT- 2021/10/13 06:00
MHDA- 2021/11/03 06:00
CRDT- 2021/10/12 20:24
PHST- 2021/07/08 00:00 [received]
PHST- 2021/09/28 00:00 [revised]
PHST- 2021/09/29 00:00 [accepted]
PHST- 2021/10/13 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2021/10/12 20:24 [entrez]
AID - S0166-445X(21)00245-9 [pii]
AID - 10.1016/j.aquatox.2021.105986 [doi]
PST - ppublish
SO  - Aquat Toxicol. 2021 Nov;240:105986. doi: 10.1016/j.aquatox.2021.105986. Epub 2021 
      Oct 5.