PMID- 34638107
OWN - NLM
STAT- MEDLINE
DCOM- 20220125
LR  - 20220125
IS  - 2057-1976 (Electronic)
IS  - 2057-1976 (Linking)
VI  - 7
IP  - 6
DP  - 2021 Oct 25
TI  - Dosimetric evaluation of different planning techniques based on flattening 
      filter-free beams for central and peripheral lung stereotactic body radiotherapy.
LID - 10.1088/2057-1976/ac2f0d [doi]
AB  - This study aimed to dosimetrically compare and evaluate the flattening 
      filter-free (FFF) photon beam-based three-dimensional conformal radiotherapy 
      (3DCRT), intensity-modulated radiation therapy (IMRT), and volumetric modulated 
      arc therapy (VMAT) for lung stereotactic body radiotherapy (SBRT). RANDO phantom 
      computed tomography (CT) images were used for treatment planning. Gross tumor 
      volumes (GTVs) were delineated in the central and peripheral lung locations. 
      Planning target volumes (PTVs) was determined by adding a 5 mm margin to the GTV. 
      3DCRT, IMRT, and VMAT plans were generated using a 6-MV FFF photon beam. Dose 
      calculations for all plans were performed using the anisotropic analytical 
      algorithm (AAA) and Acuros XB algorithms. The accuracy of the algorithms was 
      validated using the dose measured in a CIRS thorax phantom. The conformity index 
      (CI), high dose volume (HDV), low dose location (D(2cm)), and homogeneity index 
      (HI) improved with FFF-VMAT compared to FFF-IMRT and FFF-3DCRT, while low dose 
      volume (R(50%)) and gradient index (GI) showed improvement with FFF-3DCRT. 
      Compared with FFF-3DCRT, a drastic decrease in the mean treatment time (TT) value 
      was observed with FFF-VMAT for different lung sites between 57.09% and 60.39%, 
      while with FFF-IMRT it increased between 10.78% and 17.49%. The dose calculation 
      with Acuros XB was found to be superior to that of AAA. Based on the comparison 
      of dosimetric indices in this study, FFF-VMAT provides a superior treatment plan 
      to FFF-IMRT and FFF-3DCRT in the treatment of peripheral and central lung PTVs. 
      This study suggests that Acuros XB is a more accurate algorithm than AAA in the 
      lung region.
CI  - (c) 2021 IOP Publishing Ltd.
FAU - Dwivedi, Shekhar
AU  - Dwivedi S
AD  - Department of Medical Physics, Tata Memorial Centre, Homi Bhabha Cancer Hospital 
      and Research Centre, Mullanpur & Sangrur, India.
AD  - Department of Physics, Maharaja Ranjit Singh Punjab Technical University, 
      Bathinda, India.
FAU - Kansal, Sandeep
AU  - Kansal S
AD  - Department of Physics, Maharaja Ranjit Singh Punjab Technical University, 
      Bathinda, India.
FAU - Shukla, Jooli
AU  - Shukla J
AD  - Department of Physics, Dr Bhimrao Ambedkar University, Agra, India.
FAU - Bharati, Avinav
AU  - Bharati A
AD  - Department of Radiation Oncology, Dr Ram Manohar Lohia Institute of Medical 
      Sciences, Lucknow, India.
FAU - Dangwal, Vinod Kumar
AU  - Dangwal VK
AUID- ORCID: 0000-0001-8047-8036
AD  - Department of Radiotherapy, Government Medical College, Patiala, India.
LA  - eng
PT  - Journal Article
DEP - 20211025
PL  - England
TA  - Biomed Phys Eng Express
JT  - Biomedical physics & engineering express
JID - 101675002
SB  - IM
MH  - Humans
MH  - Lung/diagnostic imaging
MH  - Lung Neoplasms/diagnostic imaging
MH  - Planning Techniques
MH  - *Radiosurgery
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Thorax
OTO - NOTNLM
OT  - Acuros XB
OT  - FFF photon beam
OT  - SBRT
OT  - VMAT
OT  - planning techniques
EDAT- 2021/10/13 06:00
MHDA- 2022/01/27 06:00
CRDT- 2021/10/12 20:25
PHST- 2021/08/30 00:00 [received]
PHST- 2021/10/12 00:00 [accepted]
PHST- 2021/10/13 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/10/12 20:25 [entrez]
AID - 10.1088/2057-1976/ac2f0d [doi]
PST - epublish
SO  - Biomed Phys Eng Express. 2021 Oct 25;7(6). doi: 10.1088/2057-1976/ac2f0d.