PMID- 34638206
OWN - NLM
STAT- MEDLINE
DCOM- 20211014
LR  - 20211014
IS  - 1007-3418 (Print)
IS  - 1007-3418 (Linking)
VI  - 29
IP  - 9
DP  - 2021 Sep 20
TI  - [Non-alcoholic fatty liver disease increases the incidence rate of type 2 
      diabetes mellitus: a cohort study based on a rural town elderly population of 
      southern Jiangsu].
PG  - 867-872
LID - 10.3760/cma.j.cn501113-20200429-00223 [doi]
AB  - Objective: To investigate the impact of non-alcoholic fatty liver disease (NAFLD) 
      on the incidence of type 2 diabetes mellitus (T2DM) in an elderly population. 
      Methods: A rural elderly population of Kunshan city, Jiangsu Province were used 
      as the research subject. Prior diabetes mellitus, heavy alcohol consumption and 
      incomplete data were excluded from prospective cohort study analysis. Annual 
      physical examination and follow-up were conducted from 2007 to 2016. T2DM onset, 
      death and loss to follow-up visits were observed as the research subject end 
      points. According to the baseline physical examination results, the study 
      subjects were divided into NAFLD and control groups, and further baseline data of 
      both groups were analyzed whether there were match. The cumulative incidence rate 
      of T2DM were statistically analyzed and compared between the two groups. 
      Simultaneously, the relationship between the two groups of various indexes and 
      the newly developed T2DM were analyzed using Kaplan-Meier. The variables with P < 
      0.1 were selected and incorporated into the Cox proportional hazard regression 
      model. The impact of NAFLD on the incidence of T2DM was analyzed in an elderly 
      population. Results: At baseline, there were statistically significant 
      differences in the distribution of age, sex, waist circumference, body mass 
      index, systolic blood pressure, diastolic blood pressure, direct bilirubin, blood 
      urea nitrogen and triglycerides between NAFLD and non-NAFLD groups. However, 
      fasting blood glucose, serum creatinine, total bilirubin, total cholesterol, low 
      density lipoprotein cholesterol and high-density lipoprotein cholesterol had no 
      statistically significant differences between the two groups. After nine years of 
      follow-up, 207 newly developed T2DM cases, 52 NAFLD cases and 155 control group 
      were selected as the study subjects. The cumulative incidence rates were 4.25%, 
      10.34%, and 3.55%, respectively. Kaplan-Meier analysis result showed that there 
      were statistically significant differences in the cumulative incidence rates 
      between the two groups from five-year. NAFLD had increased the T2DM risk in an 
      elderly population by approximately 2.14 times (2.14 CI: 1.132 ~ 4.047) at 
      five-year, and then had increased year by year thereafter. Univariate analysis 
      showed that T2DM risk was 2.76 times higher in NAFLD than non-NAFLD groups (95% 
      CI: 2.015 ~ 3.777). After adjustment for gender, age, body mass index, waist 
      circumference, systolic blood pressure, diastolic blood pressure, serum 
      creatinine, triglyceride, total cholesterol, high-density lipoprotein cholesterol 
      and low-density lipoprotein cholesterol, T2DM risk ratio was 1.68 times higher in 
      NAFLD than control groups (95% CI: 1.163 ~ 2.425). Conclusion: NAFLD is an 
      independent long-term risk factor for the T2DM onset in an elderly population.
FAU - Shao, Y
AU  - Shao Y
AD  - Community Health Service Center of Jinxi town, Kunshan 215324, China.
FAU - Xu, J Y
AU  - Xu JY
AD  - Department of Gastroenterology, Xibei Hospital, Xi'an Jiaotong University of 
      Medicine, Xi'an 710004, China.
FAU - Lu, X L
AU  - Lu XL
AD  - Department of Gastroenterology, Shanghai Pudong Hospital, Fudan University of 
      Medicine, Shanghai 200120, China.
FAU - Chen, J
AU  - Chen J
AD  - Department of Gastroenterology, Xibei Hospital, Xi'an Jiaotong University of 
      Medicine, Xi'an 710004, China.
FAU - Li, T
AU  - Li T
AD  - Department of Gastroenterology, Xibei Hospital, Xi'an Jiaotong University of 
      Medicine, Xi'an 710004, China.
FAU - Wang, Y T
AU  - Wang YT
AD  - Department of Gastroenterology, Xibei Hospital, Xi'an Jiaotong University of 
      Medicine, Xi'an 710004, China.
FAU - Shi, H T
AU  - Shi HT
AD  - Department of Gastroenterology, Xibei Hospital, Xi'an Jiaotong University of 
      Medicine, Xi'an 710004, China.
LA  - chi
GR  - WBE20181025/Wang Baoen Liver Fibrosis Research Foundation of Chinese Foundation 
      for Hepatitis Prevention and Control/
GR  - 20ZR1450100/Natural Science Foundation of Shanghai/
PT  - Journal Article
PL  - China
TA  - Zhonghua Gan Zang Bing Za Zhi
JT  - Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of 
      hepatology
JID - 9710009
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Humans
MH  - Incidence
MH  - *Non-alcoholic Fatty Liver Disease/epidemiology
MH  - Prospective Studies
OTO - NOTNLM
OT  - Cohort study
OT  - Non-alcoholic fatty liver disease
OT  - The aged
OT  - Type 2 diabetes
EDAT- 2021/10/13 06:00
MHDA- 2021/10/15 06:00
CRDT- 2021/10/12 23:15
PHST- 2021/10/12 23:15 [entrez]
PHST- 2021/10/13 06:00 [pubmed]
PHST- 2021/10/15 06:00 [medline]
AID - 10.3760/cma.j.cn501113-20200429-00223 [doi]
PST - ppublish
SO  - Zhonghua Gan Zang Bing Za Zhi. 2021 Sep 20;29(9):867-872. doi: 
      10.3760/cma.j.cn501113-20200429-00223.