PMID- 34638358
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211016
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 13
IP  - 19
DP  - 2021 Sep 29
TI  - Detection of Persistent Organic Pollutants in Omental Adipose Tissue from 
      Patients with Diffuse-Gastric Cancer: A Pilot Study.
LID - 10.3390/cancers13194874 [doi]
LID - 4874
AB  - The greater omentum represents a specific adipose tissue resected with gastric 
      surgery for cancer. Diffuse gastric adenocarcinoma (diffuse-GC) is of major 
      relevance among gastric cancers due to its unknown origin, aggressiveness, and 
      metastasis in the peritoneal cavity. We postulated that persistent organic 
      pollutants (POPs) could be detected in the greater omentum. Great omentum from 
      patients with (i) diffuse-GC, or (ii) with other peritoneal metastatic cancer, 
      and (iii) control group without cancer disease were analyzed for the distribution 
      of a large panel of 96 POPs. POPs include polychlorinated dioxins/furans 
      (PCDD/Fs), polychlorobiphenyls (PCBs), polybrominated diphenyl ethers (PBDE), 
      polybrominated biphenyls (PBB), hexabromocyclododecanes, organochlorine 
      pesticides, and polycyclic aromatic hydrocarbons (PAHs). The widespread presence 
      of a substantial list of POPs (PCDDs/Fs, PCBs, and brominated flame retardants) 
      was found in the omentum from patients with aggressive diffuse-GC, with minor 
      presence of some organochlorine pesticides and PAHs at the low analyzed levels. 
      Some chemicals appeared in larger concentrations in diffuse-GC or other cancer 
      groups, including some PCDDs, PCB105, 123, 138, PBDE209, and PBB153. Overall, the 
      present pilot study provides novel information regarding POPs levels in the 
      omental fat, which is an understudied fat depot in terms of POPs load, and 
      diffuse-GC association.
FAU - Perrot-Applanat, Martine
AU  - Perrot-Applanat M
AD  - INSERM U1275, Lariboisiere Hospital, University of Paris-Diderot-Paris7, F-75010 
      Paris, France.
AD  - INSERM U1275, CAP Paris-Tech, Lariboisiere Hospital, 2 rue Ambroise Pare, F-75010 
      Paris, France.
FAU - Pimpie, Cynthia
AU  - Pimpie C
AD  - INSERM U1275, Lariboisiere Hospital, University of Paris-Diderot-Paris7, F-75010 
      Paris, France.
FAU - Cano-Sancho, German
AU  - Cano-Sancho G
AUID- ORCID: 0000-0003-4111-4007
AD  - Oniris, INRAE, LABERCA, F-44307 Nantes, France.
FAU - Antignac, Jean Philippe
AU  - Antignac JP
AD  - Oniris, INRAE, LABERCA, F-44307 Nantes, France.
FAU - Pocard, Marc
AU  - Pocard M
AUID- ORCID: 0000-0002-4793-0008
AD  - Hepato-Biliary-Pancreatic Gastrointestinal Surgery and Liver Transplantation, 
      Pitie-Salpetriere Hospital, Assistance Publique/Hopitaux de Paris, F-75013 Paris, 
      France.
LA  - eng
GR  - CRD 2016-02/Agence Nationale de Securite Sanitaire de l'Alimentation, de 
      l'Environnement et du Travail/
PT  - Journal Article
DEP - 20210929
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC8508119
OTO - NOTNLM
OT  - diffuse-gastric cancer (diffuse-GC)
OT  - metastasis
OT  - omental fat tissue
OT  - persistent organic pollutants (POPs)
OT  - polychlorinated dibenzo-p-dioxins (PCDD)
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study, in the collection, analyses, or interpretation of data, in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2021/10/14 06:00
MHDA- 2021/10/14 06:01
PMCR- 2021/09/29
CRDT- 2021/10/13 01:01
PHST- 2021/07/27 00:00 [received]
PHST- 2021/09/21 00:00 [revised]
PHST- 2021/09/26 00:00 [accepted]
PHST- 2021/10/13 01:01 [entrez]
PHST- 2021/10/14 06:00 [pubmed]
PHST- 2021/10/14 06:01 [medline]
PHST- 2021/09/29 00:00 [pmc-release]
AID - cancers13194874 [pii]
AID - cancers-13-04874 [pii]
AID - 10.3390/cancers13194874 [doi]
PST - epublish
SO  - Cancers (Basel). 2021 Sep 29;13(19):4874. doi: 10.3390/cancers13194874.