PMID- 34638475
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211016
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 13
IP  - 19
DP  - 2021 Oct 5
TI  - Type 2 Diabetes Mellitus and Clinicopathological Tumor Characteristics in Women 
      Diagnosed with Breast Cancer: A Systematic Review and Meta-Analysis.
LID - 10.3390/cancers13194992 [doi]
LID - 4992
AB  - Poor prognosis caused by type 2 diabetes mellitus (T2DM) in women with breast 
      cancer is conferred, while the association between T2DM and breast tumor 
      aggressiveness is still a matter of debate. This study aimed to clarify the 
      differences in breast cancer characteristics, including stage, size, lymph node 
      status, grade, estrogen receptor (ER), progesterone receptor (PR), and human 
      epidermal growth factor receptor (Her2), between patients with and without 
      pre-existing T2DM. PubMed, Embase, and Web of Science were searched for studies 
      from 1 January 2010 to 2 July 2021. Adjusted odds ratios (ORs) with 95% 
      confidence intervals (CIs) were pooled by using a random effects model. T2DM was 
      significantly associated with tumor stages III/IV versus cancers in situ and 
      stages I/II (pooled ORs (pOR), 95% CI: 1.19; 1.04-1.36, p = 0.012), tumor size 
      >20 versus </=20 mm (pOR, 95% CI: 1.18; 1.04-1.35, p = 0.013), and lymph node 
      invasion versus no involvement (pOR, 95% CI: 1.26; 1.05-1.51, p = 0.013). These 
      findings suggest that women with T2DM are at a higher risk of late-stage tumors, 
      large tumor sizes, and invasive lymph nodes at breast cancer diagnosis.
FAU - Zhang, Fan
AU  - Zhang F
AUID- ORCID: 0000-0001-9302-9993
AD  - Department of Epidemiology, University Medical Center Groningen, University of 
      Groningen, 9713 GZ Groningen, The Netherlands.
AD  - Department of Preventive Medicine, Shantou University Medical College, Shantou 
      515041, China.
AD  - Guangdong Provincial Key Laboratory for Breast Cancer Diagnosis and Treatment, 
      Cancer Hospital of Shantou University Medical College, Shantou 515041, China.
FAU - de Haan-Du, Jing
AU  - de Haan-Du J
AUID- ORCID: 0000-0002-3850-8112
AD  - Department of Epidemiology, University Medical Center Groningen, University of 
      Groningen, 9713 GZ Groningen, The Netherlands.
FAU - Sidorenkov, Grigory
AU  - Sidorenkov G
AD  - Department of Epidemiology, University Medical Center Groningen, University of 
      Groningen, 9713 GZ Groningen, The Netherlands.
FAU - Landman, Gijs W D
AU  - Landman GWD
AD  - Department of Internal Medicine, Gelre Hospital, 7334 DZ Apeldoorn, The 
      Netherlands.
FAU - Jalving, Mathilde
AU  - Jalving M
AUID- ORCID: 0000-0002-9142-9050
AD  - Department of Oncology, University Medical Center Groningen, University of 
      Groningen, 9713 GZ Groningen, The Netherlands.
FAU - Zhang, Qingying
AU  - Zhang Q
AD  - Department of Preventive Medicine, Shantou University Medical College, Shantou 
      515041, China.
AD  - Guangdong Provincial Key Laboratory for Breast Cancer Diagnosis and Treatment, 
      Cancer Hospital of Shantou University Medical College, Shantou 515041, China.
FAU - de Bock, Geertruida H
AU  - de Bock GH
AUID- ORCID: 0000-0003-3104-4471
AD  - Department of Epidemiology, University Medical Center Groningen, University of 
      Groningen, 9713 GZ Groningen, The Netherlands.
LA  - eng
GR  - a PhD position grant/Graduate School of Medical Sciences, University Medical 
      Center Groningen/
PT  - Journal Article
PT  - Review
DEP - 20211005
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC8508341
OTO - NOTNLM
OT  - breast cancer
OT  - lymph node status
OT  - tumor size
OT  - tumor stage
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest. The sponsors had no role in the 
      design, execution, interpretation, or writing of the study.
EDAT- 2021/10/14 06:00
MHDA- 2021/10/14 06:01
PMCR- 2021/10/05
CRDT- 2021/10/13 01:02
PHST- 2021/07/31 00:00 [received]
PHST- 2021/09/17 00:00 [revised]
PHST- 2021/09/29 00:00 [accepted]
PHST- 2021/10/13 01:02 [entrez]
PHST- 2021/10/14 06:00 [pubmed]
PHST- 2021/10/14 06:01 [medline]
PHST- 2021/10/05 00:00 [pmc-release]
AID - cancers13194992 [pii]
AID - cancers-13-04992 [pii]
AID - 10.3390/cancers13194992 [doi]
PST - epublish
SO  - Cancers (Basel). 2021 Oct 5;13(19):4992. doi: 10.3390/cancers13194992.