PMID- 34639055
OWN - NLM
STAT- MEDLINE
DCOM- 20211026
LR  - 20211026
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 19
DP  - 2021 Oct 3
TI  - Epoxyeicosatrienoic Acids and Fibrosis: Recent Insights for the Novel Therapeutic 
      Strategies.
LID - 10.3390/ijms221910714 [doi]
LID - 10714
AB  - Organ fibrosis often ends in eventual organ failure and leads to high mortality. 
      Although researchers have identified many effector cells and molecular pathways, 
      there are few effective therapies for fibrosis to date and the underlying 
      mechanism needs to be examined and defined further. Epoxyeicosatrienoic acids 
      (EETs) are endogenous lipid metabolites of arachidonic acid (ARA) synthesized by 
      cytochrome P450 (CYP) epoxygenases. EETs are rapidly metabolized primarily via 
      the soluble epoxide hydrolase (sEH) pathway. The sEH pathway produces 
      dihydroxyeicosatrienoic acids (DHETs), which have lower activity. Stabilized or 
      increased EETs levels exert several protective effects, including 
      pro-angiogenesis, anti-inflammation, anti-apoptosis, and anti-senescence. 
      Currently, intensive investigations are being carried out on their anti-fibrotic 
      effects in the kidney, heart, lung, and liver. The present review provides an 
      update on how the stabilized or increased production of EETs is a reasonable 
      theoretical basis for fibrosis treatment.
FAU - Guan, Xin-Xin
AU  - Guan XX
AD  - Department of Physiology, School of Basic Medical Science, Central South 
      University, Changsha 410078, China.
FAU - Rao, Dong-Ning
AU  - Rao DN
AUID- ORCID: 0000-0002-0953-2957
AD  - Department of Physiology, School of Basic Medical Science, Central South 
      University, Changsha 410078, China.
FAU - Liu, Yan-Zhe
AU  - Liu YZ
AD  - Department of Physiology, School of Basic Medical Science, Central South 
      University, Changsha 410078, China.
FAU - Zhou, Yong
AU  - Zhou Y
AUID- ORCID: 0000-0002-7348-2376
AD  - Department of Physiology, School of Basic Medical Science, Central South 
      University, Changsha 410078, China.
FAU - Yang, Hui-Hui
AU  - Yang HH
AD  - Department of Physiology, School of Basic Medical Science, Central South 
      University, Changsha 410078, China.
LA  - eng
GR  - 91949110/National Natural Science Foundation of China/
GR  - SKLKF201702/the Open Project of the State Key Laboratory of Trauma, Burns, and 
      Combined Injury, Army Medical University/
GR  - 18K009/High School Innovation Fund of Hunan province/
GR  - 19K103/High School Innovation Fund of Hunan province/
PT  - Journal Article
PT  - Review
DEP - 20211003
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Eicosanoids)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
SB  - IM
MH  - Animals
MH  - Arachidonic Acid/metabolism
MH  - Cytochrome P-450 Enzyme System/metabolism
MH  - Disease Management
MH  - *Disease Susceptibility
MH  - Eicosanoids/*adverse effects/metabolism
MH  - Fibrosis/*etiology/metabolism/pathology/therapy
MH  - Humans
MH  - Metabolic Networks and Pathways
MH  - Organ Specificity
PMC - PMC8509622
OTO - NOTNLM
OT  - EETs
OT  - cardiac fibrosis
OT  - hepatic fibrosis
OT  - pulmonary fibrosis
OT  - renal fibrosis
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/14 06:00
MHDA- 2021/10/27 06:00
PMCR- 2021/10/03
CRDT- 2021/10/13 01:04
PHST- 2021/09/07 00:00 [received]
PHST- 2021/09/26 00:00 [revised]
PHST- 2021/09/27 00:00 [accepted]
PHST- 2021/10/13 01:04 [entrez]
PHST- 2021/10/14 06:00 [pubmed]
PHST- 2021/10/27 06:00 [medline]
PHST- 2021/10/03 00:00 [pmc-release]
AID - ijms221910714 [pii]
AID - ijms-22-10714 [pii]
AID - 10.3390/ijms221910714 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Oct 3;22(19):10714. doi: 10.3390/ijms221910714.