PMID- 34639400
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 18
IP  - 19
DP  - 2021 Sep 26
TI  - Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: 
      The MAKE Study.
LID - 10.3390/ijerph181910098 [doi]
LID - 10098
AB  - Bisphenols are endocrine disruptors that may be associated with altered fetal 
      growth in humans, and they have similar biological functions to mimic hormones. 
      In addition, aggregated chemicals showed an adverse effect although individual 
      concentration was at a low level. However, most studies between bisphenols and 
      birth outcomes have focused on the effect of individual bisphenol. Thus, we 
      explored the associations of urinary bisphenol mixtures with birth outcomes. We 
      conducted a prospective birth cohort study in South Korea. One hundred eighty 
      mother-infant pairs were recruited from 2017 to 2019. Bisphenol A (BPA), 
      bisphenol F (BPF), and bisphenol S (BPS) in one spot urine were analyzed using 
      ultra-performance liquid chromatography-tandem mass spectrometry. We used two 
      statistical approaches to examine potential associations of BPA, BPF, and BPS 
      with birth weight and gestational age: (1) multivariable linear regression; (2) 
      Bayesian kernel machine regression (BKMR). The geometric means of BPA, BPF, and 
      BPS were 2.1, 0.2, and 0.1 mug/L, respectively. In stratified linear analyses by 
      each median value, a higher BPF was positively associated with birth weight (g) 
      (beta = 125.5; 95% CI: 45.0 to 205.9). Mixture analyses using BKMR suggested an 
      inverse association between bisphenol mixtures and birth weight. Our findings 
      suggest that in utero bisphenol exposure may influence birth weight and that such 
      relationships may differ considering non-linearity and the combined effect.
FAU - Kim, Seyoung
AU  - Kim S
AUID- ORCID: 0000-0002-0191-4272
AD  - National Cancer Control Institute, National Cancer Center, Goyang 10408, Korea.
FAU - Park, Eunjung
AU  - Park E
AUID- ORCID: 0000-0002-3586-5800
AD  - Hanyang University Institute for Rheumatology Research, Seoul 04763, Korea.
FAU - Park, Eun-Kyo
AU  - Park EK
AD  - Department of Occupational and Environmental Medicine, Ewha Medical Research 
      Institute, Seoul 07804, Korea.
FAU - Lee, Seulbi
AU  - Lee S
AD  - Department of Epidemiology, University of Michigan School of Public Health, Ann 
      Arbor, MI 48109, USA.
FAU - Kwon, Jeoung-A
AU  - Kwon JA
AD  - Institute of Health Services Research, Yonsei University, Seoul 03722, Korea.
FAU - Shin, Bo-Hye
AU  - Shin BH
AUID- ORCID: 0000-0001-8637-3059
AD  - National Cancer Control Institute, National Cancer Center, Goyang 10408, Korea.
AD  - Department of Population Health Sciences, Faculty of Life Sciences & Medicine, 
      King's College London, London WC2R 2LS, UK.
FAU - Kang, Sora
AU  - Kang S
AD  - Department of Medical Informatics, School of Medicine, Ajou University, Suwon 
      16499, Korea.
FAU - Park, Eun-Young
AU  - Park EY
AD  - National Cancer Control Institute, National Cancer Center, Goyang 10408, Korea.
FAU - Kim, Byungmi
AU  - Kim B
AUID- ORCID: 0000-0001-8621-9190
AD  - National Cancer Control Institute, National Cancer Center, Goyang 10408, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210926
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Phenols)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Bayes Theorem
MH  - *Benzhydryl Compounds
MH  - Cohort Studies
MH  - *Endocrine Disruptors
MH  - Female
MH  - Humans
MH  - Phenols
MH  - Pregnancy
MH  - Prospective Studies
PMC - PMC8508042
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - birth outcome
OT  - birth weight
OT  - bisphenol
OT  - mixtures analyses
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2021/10/14 06:00
MHDA- 2021/10/26 06:00
PMCR- 2021/09/26
CRDT- 2021/10/13 01:06
PHST- 2021/08/19 00:00 [received]
PHST- 2021/09/20 00:00 [revised]
PHST- 2021/09/21 00:00 [accepted]
PHST- 2021/10/13 01:06 [entrez]
PHST- 2021/10/14 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/09/26 00:00 [pmc-release]
AID - ijerph181910098 [pii]
AID - ijerph-18-10098 [pii]
AID - 10.3390/ijerph181910098 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2021 Sep 26;18(19):10098. doi: 
      10.3390/ijerph181910098.