PMID- 34642187
OWN - NLM
STAT- MEDLINE
DCOM- 20211102
LR  - 20211102
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 11
IP  - 10
DP  - 2021 Oct 12
TI  - Association between dietary antioxidant vitamins intake and homocysteine levels 
      in middle-aged and older adults with hypertension: a cross-sectional study.
PG  - e045732
LID - 10.1136/bmjopen-2020-045732 [doi]
LID - e045732
AB  - OBJECTIVES: Plasma total homocysteine (tHcy) has been implicated in the 
      development of cardiovascular disease. This study aimed to assess the 
      relationship of dietary antioxidant vitamins intake with tHcy levels in 
      middle-aged and older adults with hypertension. DESIGN: A cross-sectional study. 
      SETTING: The survey was conducted in the Nanshan district of Shenzhen. 
      PARTICIPANTS: A total of 1465 middle-aged and older adults with hypertension were 
      included between July and September of 2013. MEASUREMENTS: Hyperhomocysteinaemia 
      (HHcy) was defined as tHcy >/=15 micromol/L. Some dietary antioxidant vitamins (vitamin 
      C (VC) and vitamin E (VE), carotenes, retinol, lutein) intake was estimated using 
      the Food Frequency Questionnaire. Sociodemographic and potential covariates were 
      evaluated through questionnaires, anthropometric measurements and blood tests. 
      The association between dietary intakes of antioxidant vitamins and tHcy 
      concentration were evaluated by multiple linear regression analyses after 
      napierian logarithm transformed. Multiple logistic regression models were further 
      used to determine ORs and 95% CIs. RESULTS: The beta (95% CIs) of VC intake and tHcy 
      was -0.050 (-0.084 to -0.016). Compared with the lowest quartile in the fully 
      adjusted model, the ORs (95% CIs) for HHcy levels across quartiles of dietary VC 
      intake were 0.82 (0.57 to 1.16), 0.49 (0.33 to 0.74) and 0.40 (0.22 to 0.74) (p 
      for trend=0.001). The beta (95% CIs) of retinol intake and tHcy was -0.021 (-0.041 
      to -0.002) and the ORs (95% CIs) in the third quartile of retinol intake was 0.61 
      (0.42 to 0.86), while the effect for the highest quartile was not significant (p 
      for trend=0.951). No significant association was observed between dietary VE, 
      carotenes and lutein intake and HHcy. CONCLUSIONS: A linear inverse association 
      between dietary VC intake and HHcy prevalence, and an L-shaped association 
      between dietary retinol intake and HHcy prevalence were found in Chinese 
      middle-aged and older adults with hypertension.
CI  - (c) Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Peng, Xiaolin
AU  - Peng X
AD  - Department of Tumor, Injury and Nutrition, Nanshan Centre for Chronic Disease 
      Control, Shenzhen, Guangdong, People's Republic of China.
FAU - Gao, Qin
AU  - Gao Q
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, People's 
      Republic of China.
AD  - Department of Public Health, Jining Medical College, Jining, Shandong, People's 
      Republic of China.
FAU - Zhou, Juan
AU  - Zhou J
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, People's 
      Republic of China.
FAU - Ma, Jianping
AU  - Ma J
AD  - Department of Tumor, Injury and Nutrition, Nanshan Centre for Chronic Disease 
      Control, Shenzhen, Guangdong, People's Republic of China.
FAU - Zhao, Dan
AU  - Zhao D
AD  - Department of Tumor, Injury and Nutrition, Nanshan Centre for Chronic Disease 
      Control, Shenzhen, Guangdong, People's Republic of China.
FAU - Hao, Liping
AU  - Hao L
AUID- ORCID: 0000-0001-8844-0892
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, People's 
      Republic of China haolp@mails.tjmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211012
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
RN  - 0 (Antioxidants)
RN  - 0 (Vitamins)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 11103-57-4 (Vitamin A)
SB  - IM
MH  - Aged
MH  - *Antioxidants
MH  - Cross-Sectional Studies
MH  - Eating
MH  - Homocysteine
MH  - Humans
MH  - *Hypertension/epidemiology
MH  - Middle Aged
MH  - Vitamin A
MH  - Vitamins
PMC - PMC8513268
OTO - NOTNLM
OT  - cardiac epidemiology
OT  - epidemiology
OT  - hypertension
COIS- Competing interests: None declared.
EDAT- 2021/10/14 06:00
MHDA- 2021/11/03 06:00
PMCR- 2021/10/12
CRDT- 2021/10/13 06:20
PHST- 2021/10/13 06:20 [entrez]
PHST- 2021/10/14 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2021/10/12 00:00 [pmc-release]
AID - bmjopen-2020-045732 [pii]
AID - 10.1136/bmjopen-2020-045732 [doi]
PST - epublish
SO  - BMJ Open. 2021 Oct 12;11(10):e045732. doi: 10.1136/bmjopen-2020-045732.