PMID- 34642272
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220427
IS  - 2093-0879 (Print)
IS  - 2093-0887 (Electronic)
IS  - 2093-0879 (Linking)
VI  - 27
IP  - 4
DP  - 2021 Oct 30
TI  - Esophageal Nocturnal Baseline Impedance and Post-reflux Swallow-induced 
      Peristaltic Wave Index in Identifying Proton Pump Inhibitor-refractory 
      Non-erosive Reflux Disease.
PG  - 525-532
LID - 10.5056/jnm20073 [doi]
AB  - BACKGROUND/AIMS: Esophageal mean nocturnal baseline impedance (MNBI) levels and 
      post-reflux swallow-induced peristaltic wave (PSPW) index could increase the 
      diagnostic value of 24-hour multichannel intraluminal impedance and pH monitoring 
      in patients with gastroesophageal reflux disease. This study aims to compare the 
      MNBI and PSPW index in patients with no evidence of erosive reflux disease. 
      METHODS: Impedance-pH monitoring tracings from 70 patients, 50 with non-erosive 
      reflux disease (NERD) and 20 with functional heartburn (FH), were reviewed. 
      According to proton pump inhibitors (PPI) treatment response, NERD patients were 
      divided into NERD/PPI responders and NERD/PPI nonresponders. MNBI, PSPW index, 
      and intercellular spaces were measured and compared among each group. RESULTS: 
      MNBI values and PSPW index were lower in NERD patients than in FH (P < 0.01 and P 
      < 0.05, respectively). MNBI positively correlated with PSPW index (r = 0.525, P < 
      0.001). NERD/PPI responders had lower MNBI values and PSPW index compared to 
      NERD/PPI nonresponders (both P < 0.01). MNBI and PSPW index distinguished NERD 
      from FH patients with an area under the curve of 0.914 and 0.677, respectively. 
      Wider intercellular space could be identified in patients with NERD (P < 0.01). 
      CONCLUSION: MNBI and PSPW index may differentiate NERD from FH patients and 
      relate to PPI treatment efficacy in patients with NERD.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, China.
FAU - Ye, Bixing
AU  - Ye B
AD  - Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, China.
FAU - Wang, Meifeng
AU  - Wang M
AD  - Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, China.
FAU - Lin, Lin
AU  - Lin L
AD  - Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, China.
FAU - Jiang, Liuqin
AU  - Jiang L
AD  - Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, China.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Neurogastroenterol Motil
JT  - Journal of neurogastroenterology and motility
JID - 101530189
PMC - PMC8521464
OTO - NOTNLM
OT  - Electric impedance
OT  - Gastroesophageal reflux
OT  - Intercellular spaces
OT  - Proton pump inhibitors
COIS- Conflicts of interest: None.
EDAT- 2021/10/14 06:00
MHDA- 2021/10/14 06:01
PMCR- 2021/10/30
CRDT- 2021/10/13 06:21
PHST- 2020/04/13 00:00 [received]
PHST- 2021/04/15 00:00 [revised]
PHST- 2021/04/15 00:00 [accepted]
PHST- 2021/10/13 06:21 [entrez]
PHST- 2021/10/14 06:00 [pubmed]
PHST- 2021/10/14 06:01 [medline]
PHST- 2021/10/30 00:00 [pmc-release]
AID - jnm20073 [pii]
AID - jnm-27-4-525 [pii]
AID - 10.5056/jnm20073 [doi]
PST - ppublish
SO  - J Neurogastroenterol Motil. 2021 Oct 30;27(4):525-532. doi: 10.5056/jnm20073.