PMID- 34642280
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220427
IS  - 2093-0879 (Print)
IS  - 2093-0887 (Electronic)
IS  - 2093-0879 (Linking)
VI  - 27
IP  - 4
DP  - 2021 Oct 30
TI  - Self-reported Wheat Sensitivity in Irritable Bowel Syndrome and Healthy Subjects: 
      Prevalence of Celiac Markers and Response to Wheat-free Diet.
PG  - 596-601
LID - 10.5056/jnm20086 [doi]
AB  - BACKGROUND/AIMS: Most patients with irritable bowel syndrome (IBS) report 
      food-related aggravation of symptoms. Wheat/gluten is one of the most commonly 
      incriminated. We studied the prevalence of self-reported wheat sensitivity in 
      patients with IBS and in a healthy population from a region in India consuming 
      mixed-cereal diets, correlated it with serological and human leukocyte antigen 
      (HLA) markers of celiac disease, and evaluated the response to a wheat-free diet. 
      METHODS: We surveyed 204 patients with IBS and 400 healthy persons for 
      self-reported wheat sensitivity. Testing for IgA anti-tissue transglutaminase and 
      HLA DQ2 or DQ8 was done in individuals who reported wheat sensitivity. Consenting 
      persons with wheat sensitivity were put on wheat-free diet and monitored for 
      symptom change. RESULTS: Twenty-three of 204 patients with IBS (11.3%) and none 
      of the healthy subjects self-reported wheat sensitivity. Of 23 patients, 14 
      (60.9%) were positive for HLA DQ2 or DQ8 and none for anti-tissue 
      transglutaminase antibody. After 6 weeks on wheat-free diet, all 19 participating 
      patients reported clinical improvement; fewer patients had bloating, diarrhea, 
      constipation, and easy fatigue. CONCLUSIONS: Eleven percent of patients with IBS 
      self-reported wheat sensitivity. None of them had positive celiac serology; 60.9% 
      were positive for HLA DQ2 and DQ8, suggesting a possible genetic basis. All of 
      them improved symptomatically on a wheat-free diet.
FAU - Dhoble, Pavan
AU  - Dhoble P
AD  - Division of Gastroenterology, P D Hinduja Hospital, Mumbai, India.
FAU - Abraham, Philip
AU  - Abraham P
AD  - Division of Gastroenterology, P D Hinduja Hospital, Mumbai, India.
FAU - Desai, Devendra
AU  - Desai D
AD  - Division of Gastroenterology, P D Hinduja Hospital, Mumbai, India.
FAU - Joshi, Anand
AU  - Joshi A
AD  - Division of Gastroenterology, P D Hinduja Hospital, Mumbai, India.
FAU - Gupta, Tarun
AU  - Gupta T
AD  - Division of Gastroenterology, P D Hinduja Hospital, Mumbai, India.
FAU - Doctor, Shachish
AU  - Doctor S
AD  - Division of Gastroenterology, P D Hinduja Hospital, Mumbai, India.
FAU - Deshpande, Anand
AU  - Deshpande A
AD  - Department of Transfusion Medicine, P D Hinduja Hospital, Mumbai, India.
FAU - Basavanna, Rajeshwari
AU  - Basavanna R
AD  - Department of Transfusion Medicine, P D Hinduja Hospital, Mumbai, India.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Neurogastroenterol Motil
JT  - Journal of neurogastroenterology and motility
JID - 101530189
PMC - PMC8521475
OTO - NOTNLM
OT  - Food sensitivity
OT  - Gluten sensitivity
OT  - HLA typing
OT  - Non-celiac gluten sensitivity
OT  - Transglutaminases
COIS- Conflicts of interest: None.
EDAT- 2021/10/14 06:00
MHDA- 2021/10/14 06:01
PMCR- 2021/10/30
CRDT- 2021/10/13 06:21
PHST- 2020/04/23 00:00 [received]
PHST- 2020/10/06 00:00 [revised]
PHST- 2020/11/24 00:00 [accepted]
PHST- 2021/10/13 06:21 [entrez]
PHST- 2021/10/14 06:00 [pubmed]
PHST- 2021/10/14 06:01 [medline]
PHST- 2021/10/30 00:00 [pmc-release]
AID - jnm20086 [pii]
AID - jnm-27-4-596 [pii]
AID - 10.5056/jnm20086 [doi]
PST - ppublish
SO  - J Neurogastroenterol Motil. 2021 Oct 30;27(4):596-601. doi: 10.5056/jnm20086.