PMID- 34642600
OWN - NLM
STAT- MEDLINE
DCOM- 20211018
LR  - 20211018
IS  - 2046-1402 (Electronic)
IS  - 2046-1402 (Linking)
VI  - 10
DP  - 2021
TI  - Case Report: Diabetic nephropathy aggravates the progression and prognosis of 
      COVID-19-associated acute limb ischemia.
PG  - 584
LID - 10.12688/f1000research.54193.2 [doi]
LID - 584
AB  - Hypercoagulation is a hallmark of both the novel coronavirus disease (COVID-19) 
      and type 2 diabetes mellitus (T2DM). It increases the risk for vascular 
      thrombosis, including peripheral artery diseases. Among others, acute limb 
      ischemia (ALI) is one of most common complications that requires immediate and 
      prompt treatments to reduce morbidity and mortality. However, the complex 
      interplay between COVID-19, T2DM and its complications (e.g., diabetic 
      nephropathy), and ALI creates a great challenge in the management of the disease. 
      Here, we present a case of a 59-year-old diabetic female with progressive pain in 
      her left leg in the last five years, which was significantly intensified 
      following COVID-19 diagnosis. Bluish coloration, numbness and functional 
      impairments were observed during examinations with no palpable pulsation on left 
      posterior tibial and dorsalis pedis arteries. The patient also had diabetic 
      nephropathy (stage III), hypoalbuminemia, anemia and a urinary tract infection 
      that complicated the management of the disease. Due to the excruciating pain and 
      the worsening of the limb conditions, right leg revascularization and left leg 
      amputation were performed at day 14 after admission. Following the surgeries, no 
      more pain was observed and patient was discharged for further follow-up at the 
      outpatient clinic.
CI  - Copyright: (c) 2021 Hertanto DM et al.
FAU - Hertanto, Decsa Medika
AU  - Hertanto DM
AD  - Department of Internal Medicine, Faculty of Medicine, Airlangga University, 
      Surabaya, Jawa Timur, 60132, Indonesia.
AD  - Department of Internal Medicine, Dr. Soetomo Hospital, Surabaya, Jawa Timur, 
      60286, Indonesia.
FAU - Sutanto, Henry
AU  - Sutanto H
AUID- ORCID: 0000-0002-5730-2013
AD  - Department of Cardiology, Maastricht University, Maastricht, Limburg, 6229ER, The 
      Netherlands.
AD  - Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 
      Brooklyn, New York, 11203, USA.
FAU - Adi, Soebagijo
AU  - Adi S
AUID- ORCID: 0000-0002-7594-0123
AD  - Department of Internal Medicine, Faculty of Medicine, Airlangga University, 
      Surabaya, Jawa Timur, 60132, Indonesia.
AD  - Division of Endocrinology, Diabetes and Metabolism, Department of Internal 
      Medicine, Dr. Soetomo Hospital, Surabaya, Jawa Timur, 60286, Indonesia.
LA  - eng
PT  - Case Reports
DEP - 20210716
PL  - England
TA  - F1000Res
JT  - F1000Research
JID - 101594320
SB  - IM
MH  - *COVID-19
MH  - COVID-19 Testing
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Diabetic Nephropathies
MH  - Female
MH  - Humans
MH  - Ischemia/etiology
MH  - Middle Aged
MH  - Prognosis
MH  - SARS-CoV-2
PMC - PMC8430448
OTO - NOTNLM
OT  - acute limb ischemia; COVID-19; diabetes mellitus; diabetic nephropathy; limb 
      amputation; hypercoagulability; vascular thrombosis
OT  - case report
COIS- No competing interests were disclosed.
EDAT- 2021/10/15 06:00
MHDA- 2021/10/21 06:00
PMCR- 2021/09/17
CRDT- 2021/10/14 06:36
PHST- 2021/09/10 00:00 [accepted]
PHST- 2021/10/14 06:36 [entrez]
PHST- 2021/10/15 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2021/09/17 00:00 [pmc-release]
AID - 10.12688/f1000research.54193.2 [doi]
PST - epublish
SO  - F1000Res. 2021 Jul 16;10:584. doi: 10.12688/f1000research.54193.2. eCollection 
      2021.