PMID- 34643680 OWN - NLM STAT- MEDLINE DCOM- 20220602 LR - 20220723 IS - 1460-2199 (Electronic) IS - 1047-3211 (Linking) VI - 32 IP - 11 DP - 2022 May 31 TI - Developmental Sex Differences in Negative Emotion Decision-Making Dynamics: Computational Evidence and Amygdala-Prefrontal Pathways. PG - 2478-2491 LID - 10.1093/cercor/bhab359 [doi] AB - Sex differences in human emotion and related decision-making behaviors are recognized, which can be traced back early in development. However, our understanding of their underlying neurodevelopmental mechanisms remains elusive. Using developmental functional magnetic resonance imaging and computational approach, we investigated developmental sex differences in latent decision-making dynamics during negative emotion processing and related neurocognitive pathways in 243 school-aged children and 78 young adults. Behaviorally, girls exhibit higher response caution and more effective evidence accumulation, whereas boys show more impulsive response to negative facial expression stimuli. These effects parallel sex differences in emotion-related brain maturity linking to evidence accumulation, along with age-related decrease in emotional response in the basolateral amygdala and medial prefrontal cortex (MPFC) in girls and an increase in the centromedial amygdala (CMA) in boys. Moreover, girls exhibit age-related decreases in BLA-MPFC coupling linked to evidence accumulation, but boys exhibit increases in CMA-insula coupling associated with response caution. Our findings highlight the neurocomputational accounts for developmental sex differences in emotion and emotion-related behaviors and provide important implications into the neurodevelopmental mechanisms of sex differences in latent emotional decision-making dynamics. This informs the emergence of sex differences in typical and atypical neurodevelopment of children's emotion and related functions. CI - (c) The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. FAU - Xu, Jiahua AU - Xu J AD - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. AD - Key Laboratory of Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, 100875, China. FAU - Hao, Lei AU - Hao L AD - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. AD - Key Laboratory of Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, 100875, China. FAU - Chen, Menglu AU - Chen M AD - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. AD - Key Laboratory of Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, 100875, China. FAU - He, Ying AU - He Y AD - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. AD - Key Laboratory of Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, 100875, China. FAU - Jiang, Min AU - Jiang M AD - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. AD - Key Laboratory of Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, 100875, China. FAU - Tian, Ting AU - Tian T AD - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. AD - Key Laboratory of Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, 100875, China. FAU - Wang, Hui AU - Wang H AD - Faculty of Psychology, School of Artificial Intelligence, Beijing Normal University, Beijing, 100875, China. FAU - Wang, Yanpei AU - Wang Y AD - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. FAU - Wang, Daoyang AU - Wang D AD - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. AD - Department of Psychology, Hangzhou Normal University, Hangzhou, 311121, China. FAU - Han, Zhuo Rachel AU - Han ZR AD - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. AD - Key Laboratory of Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, 100875, China. FAU - Tan, Shuping AU - Tan S AD - Beijing HuiLongGuan Hospital, Peking University, Beijing, 100096, China. FAU - Men, Weiwei AU - Men W AD - Center for MRI Research, Academy for Advanced Interdisciplinary Studies & McGovern Institute for Brain Research, Peking University, Beijing, 100871, China. FAU - Gao, Jiahong AU - Gao J AD - Center for MRI Research, Academy for Advanced Interdisciplinary Studies & McGovern Institute for Brain Research, Peking University, Beijing, 100871, China. FAU - He, Yong AU - He Y AD - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. AD - Key Laboratory of Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, 100875, China. FAU - Tao, Sha AU - Tao S AD - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. FAU - Dong, Qi AU - Dong Q AD - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. FAU - Qin, Shaozheng AU - Qin S AD - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. AD - Key Laboratory of Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, 100875, China. AD - Chinese Institute for Brain Research, Beijing, 102206, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Cereb Cortex JT - Cerebral cortex (New York, N.Y. : 1991) JID - 9110718 SB - IM MH - *Amygdala/diagnostic imaging/physiology MH - Child MH - Emotions/physiology MH - Female MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Neural Pathways/diagnostic imaging/physiology MH - Prefrontal Cortex/diagnostic imaging/physiology MH - *Sex Characteristics MH - Young Adult OTO - NOTNLM OT - children OT - development OT - emotion OT - sex dimorphism OT - task fMRI EDAT- 2021/10/14 06:00 MHDA- 2022/06/03 06:00 CRDT- 2021/10/13 12:21 PHST- 2021/03/30 00:00 [received] PHST- 2021/09/02 00:00 [revised] PHST- 2021/09/02 00:00 [accepted] PHST- 2021/10/14 06:00 [pubmed] PHST- 2022/06/03 06:00 [medline] PHST- 2021/10/13 12:21 [entrez] AID - 6395308 [pii] AID - 10.1093/cercor/bhab359 [doi] PST - ppublish SO - Cereb Cortex. 2022 May 31;32(11):2478-2491. doi: 10.1093/cercor/bhab359.