PMID- 34643916
OWN - NLM
STAT- MEDLINE
DCOM- 20220107
LR  - 20220107
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 2387
DP  - 2022
TI  - Determination of Bioenergetic Parameters in Mycobacterium ulcerans.
PG  - 219-230
LID - 10.1007/978-1-0716-1779-3_21 [doi]
AB  - The oxidative phosphorylation (OxPhos) pathway has emerged as an attractive 
      pathway for the development of anti-mycobacterial drugs. The OxPhos pathway is 
      essential for ATP resynthesis and maintenance of the electrochemical 
      transmembrane gradient. The bioenergetic parameters of the pathway such as oxygen 
      consumption rate and ATP levels are quantifiable using current technology. 
      Measuring these parameters are useful tools to gauge rapidly the impact of drug 
      candidates on their capacity to inhibit the OxPhos pathway in Mycobacterium 
      ulcerans.
CI  - (c) 2022. The Author(s), under exclusive license to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Thomas, Sangeeta Susan
AU  - Thomas SS
AD  - NTU Institute for Health Technologies (HealthTech NTU), Interdisciplinary 
      Graduate Programme, Nanyang Technological University, Singapore, Singapore.
AD  - Lee Kong Chian School of Medicine, Experimental Medicine Building, Nanyang 
      Technological University, Singapore, Singapore.
FAU - Pethe, Kevin
AU  - Pethe K
AD  - Lee Kong Chian School of Medicine, Experimental Medicine Building, Nanyang 
      Technological University, Singapore, Singapore. kevin.pethe@ntu.edu.sg.
AD  - School of Biological Sciences, Nanyang Technological University, Singapore, 
      Singapore. kevin.pethe@ntu.edu.sg.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate
MH  - Buruli Ulcer
MH  - Energy Metabolism
MH  - Humans
MH  - *Mycobacterium ulcerans
OTO - NOTNLM
OT  - ATP quantitation
OT  - Bedaquiline
OT  - Buruli ulcer
OT  - Mycobacterium tuberculosis
OT  - Oxidative phosphorylation
OT  - Oxygen consumption rate
OT  - Q203
OT  - Telacebec
EDAT- 2021/10/14 06:00
MHDA- 2022/01/08 06:00
CRDT- 2021/10/13 12:31
PHST- 2021/10/13 12:31 [entrez]
PHST- 2021/10/14 06:00 [pubmed]
PHST- 2022/01/08 06:00 [medline]
AID - 10.1007/978-1-0716-1779-3_21 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2022;2387:219-230. doi: 10.1007/978-1-0716-1779-3_21.