PMID- 34644593 OWN - NLM STAT- MEDLINE DCOM- 20220214 LR - 20220716 IS - 1095-9572 (Electronic) IS - 1053-8119 (Print) IS - 1053-8119 (Linking) VI - 245 DP - 2021 Dec 15 TI - Contribution of animal models toward understanding resting state functional connectivity. PG - 118630 LID - S1053-8119(21)00903-4 [pii] LID - 10.1016/j.neuroimage.2021.118630 [doi] AB - Functional connectivity, which reflects the spatial and temporal organization of intrinsic activity throughout the brain, is one of the most studied measures in human neuroimaging research. The noninvasive acquisition of resting state functional magnetic resonance imaging (rs-fMRI) allows the characterization of features designated as functional networks, functional connectivity gradients, and time-varying activity patterns that provide insight into the intrinsic functional organization of the brain and potential alterations related to brain dysfunction. Functional connectivity, hence, captures dimensions of the brain's activity that have enormous potential for both clinical and preclinical research. However, the mechanisms underlying functional connectivity have yet to be fully characterized, hindering interpretation of rs-fMRI studies. As in other branches of neuroscience, the identification of the neurophysiological processes that contribute to functional connectivity largely depends on research conducted on laboratory animals, which provide a platform where specific, multi-dimensional investigations that involve invasive measurements can be carried out. These highly controlled experiments facilitate the interpretation of the temporal correlations observed across the brain. Indeed, information obtained from animal experimentation to date is the basis for our current understanding of the underlying basis for functional brain connectivity. This review presents a compendium of some of the most critical advances in the field based on the efforts made by the animal neuroimaging community. CI - Copyright (c) 2021 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Pais-Roldan, Patricia AU - Pais-Roldan P AD - Medical Imaging Physics, Institute of Neuroscience and Medicine 4, Forschungszentrum Julich 52425, Germany. FAU - Mateo, Celine AU - Mateo C AD - Department of Physics, University of California San Diego, La Jolla, CA 92093, USA. FAU - Pan, Wen-Ju AU - Pan WJ AD - Wallace H. Coulter Department of Biomedical Engineering, Emory University/Georgia Institute of Technology, Atlanta, GA 30322, USA. FAU - Acland, Ben AU - Acland B AD - Department of Neuroscience, Washington University School of Medicine, Saint Louis, MO 63110, USA. FAU - Kleinfeld, David AU - Kleinfeld D AD - Department of Physics, University of California San Diego, La Jolla, CA 92093, USA; Section of Neurobiology, University of California, La Jolla, San Diego, CA 92093, USA. FAU - Snyder, Lawrence H AU - Snyder LH AD - Department of Neuroscience, Washington University School of Medicine, Saint Louis, MO 63110, USA. FAU - Yu, Xin AU - Yu X AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. FAU - Keilholz, Shella AU - Keilholz S AD - Wallace H. Coulter Department of Biomedical Engineering, Emory University/Georgia Institute of Technology, Atlanta, GA 30322, USA. Electronic address: shella.keilholz@bme.gatech.edu. LA - eng GR - R35 NS097265/NS/NINDS NIH HHS/United States GR - RF1 NS113278/NS/NINDS NIH HHS/United States GR - U19 NS123717/NS/NINDS NIH HHS/United States GR - R34 NS118618/NS/NINDS NIH HHS/United States GR - R01 NS120594/NS/NINDS NIH HHS/United States GR - R01 NS078095/NS/NINDS NIH HHS/United States GR - S10 MH124733/MH/NIMH NIH HHS/United States GR - R01 MH111416/MH/NIMH NIH HHS/United States GR - R01 NS122904/NS/NINDS NIH HHS/United States GR - R01 MH111438/MH/NIMH NIH HHS/United States GR - R01 AG062581/AG/NIA NIH HHS/United States GR - R01 EB029857/EB/NIBIB NIH HHS/United States GR - R01 EY012135/EY/NEI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Review DEP - 20211010 PL - United States TA - Neuroimage JT - NeuroImage JID - 9215515 SB - IM MH - Animals MH - Connectome/*methods MH - *Magnetic Resonance Imaging MH - *Models, Animal MH - *Neuroimaging MH - Rest PMC - PMC9031339 MID - NIHMS1796165 EDAT- 2021/10/14 06:00 MHDA- 2022/02/15 06:00 PMCR- 2022/04/22 CRDT- 2021/10/13 20:07 PHST- 2021/04/01 00:00 [received] PHST- 2021/08/06 00:00 [revised] PHST- 2021/09/29 00:00 [accepted] PHST- 2021/10/14 06:00 [pubmed] PHST- 2022/02/15 06:00 [medline] PHST- 2021/10/13 20:07 [entrez] PHST- 2022/04/22 00:00 [pmc-release] AID - S1053-8119(21)00903-4 [pii] AID - 10.1016/j.neuroimage.2021.118630 [doi] PST - ppublish SO - Neuroimage. 2021 Dec 15;245:118630. doi: 10.1016/j.neuroimage.2021.118630. Epub 2021 Oct 10.