PMID- 34645091
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 0219-6352 (Print)
IS  - 0219-6352 (Linking)
VI  - 20
IP  - 3
DP  - 2021 Sep 30
TI  - Suppressors of cytokine signaling 1 protein in a regenerative model of the Gekko 
      japonicus spinal cord.
PG  - 585-594
LID - 10.31083/j.jin2003062 [doi]
AB  - Demyelination is one of the pathological outcomes that occur immediately 
      following spinal cord injury. Protection of oligodendrocytes against 
      death/apoptosis proves to be beneficial for the preservation of neurological 
      functions. Suppressors of cytokine signaling 1 protein inhibit the harmful 
      effects of several inflammatory cytokines on oligodendrocytes, but its roles in 
      spinal cord injury (SCI) induced apoptosis of oligodendrocytes remain unclear. We 
      cloned suppressors of cytokine signaling 1 cDNA from Gekko japonicus (Japanese 
      gecko) and analyzed the protein structure revealing the conserved domains 
      contained in other vertebrate suppressors of cytokine signaling 1 proteins. The 
      gecko suppressors of cytokine signaling 1 protein expression were increased in 
      the injured spinal cord following gecko tail amputation and displayed 
      colocalization with oligodendrocytes. The enforced expression of gecko 
      suppressors of cytokine signaling 1 by adenovirus in the Gsn3 gecko 
      oligodendrocyte cell line demonstrated that gecko suppressors of cytokine 
      signaling 1 significantly suppressed cell apoptosis-induced by glucose 
      deprivation. Determination of apoptosis-related proteins revealed that gecko 
      suppressors of cytokine signaling 1 was able to activate extracellular regulated 
      protein kinases (ERK) and serine/threonine protein kinases (Akt). The results 
      presented a distinct protective role of gecko suppressors of cytokine signaling 1 
      in the regenerative model of the spinal cord, which may provide new cues for 
      central nervous system repair in mammals.
CI  - (c) 2021 The Author(s). Published by IMR Press.
FAU - He, Bingqiang
AU  - He B
AD  - Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, 
      Co-innovation Center of Neuroregeneration, Nantong University, 226019 Nantong, 
      Jiangsu, China.
FAU - Wang, Wenjuan
AU  - Wang W
AD  - Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, 
      Co-innovation Center of Neuroregeneration, Nantong University, 226019 Nantong, 
      Jiangsu, China.
FAU - Sun, Chunshuai
AU  - Sun C
AD  - Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, 
      Co-innovation Center of Neuroregeneration, Nantong University, 226019 Nantong, 
      Jiangsu, China.
FAU - Yang, Ting
AU  - Yang T
AD  - Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, 
      Co-innovation Center of Neuroregeneration, Nantong University, 226019 Nantong, 
      Jiangsu, China.
FAU - Li, Hui
AU  - Li H
AD  - Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, 
      Co-innovation Center of Neuroregeneration, Nantong University, 226019 Nantong, 
      Jiangsu, China.
FAU - Chen, Xiaojun
AU  - Chen X
AD  - Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, 
      Co-innovation Center of Neuroregeneration, Nantong University, 226019 Nantong, 
      Jiangsu, China.
FAU - Liang, Hao
AU  - Liang H
AD  - Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, 
      Co-innovation Center of Neuroregeneration, Nantong University, 226019 Nantong, 
      Jiangsu, China.
FAU - Song, Honghua
AU  - Song H
AD  - Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, 
      Co-innovation Center of Neuroregeneration, Nantong University, 226019 Nantong, 
      Jiangsu, China.
FAU - Wang, Yongjun
AU  - Wang Y
AD  - Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, 
      Co-innovation Center of Neuroregeneration, Nantong University, 226019 Nantong, 
      Jiangsu, China.
FAU - Wang, Yingjie
AU  - Wang Y
AD  - Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, 
      Co-innovation Center of Neuroregeneration, Nantong University, 226019 Nantong, 
      Jiangsu, China.
LA  - eng
GR  - 2018YFC1105603/National Key Research and Development Program of China/
GR  - 31702022/National Natural Science Foundation of China/
GR  - 31871211/National Natural Science Foundation of China/
GR  - Priority Academic Program Development of Jiangsu Higher Education Institutions 
      (PAPD)/
PT  - Journal Article
PL  - Singapore
TA  - J Integr Neurosci
JT  - Journal of integrative neuroscience
JID - 101156357
RN  - 0 (Suppressor of Cytokine Signaling 1 Protein)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Cells, Cultured
MH  - Disease Models, Animal
MH  - Lizards
MH  - Nerve Regeneration/*physiology
MH  - Spinal Cord Injuries/*metabolism
MH  - Suppressor of Cytokine Signaling 1 Protein/*metabolism
OTO - NOTNLM
OT  - Apoptosis
OT  - Cytokine signaling
OT  - Neurophylogenetics
OT  - Neuroregeneration
OT  - Oligodendrocyte
OT  - Reptile
OT  - Spinal cord
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/15 06:00
MHDA- 2022/02/01 06:00
CRDT- 2021/10/14 01:55
PHST- 2021/05/13 00:00 [received]
PHST- 2021/06/15 00:00 [revised]
PHST- 2021/07/16 00:00 [accepted]
PHST- 2021/10/14 01:55 [entrez]
PHST- 2021/10/15 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
AID - 1632962193589-693704469 [pii]
AID - 10.31083/j.jin2003062 [doi]
PST - ppublish
SO  - J Integr Neurosci. 2021 Sep 30;20(3):585-594. doi: 10.31083/j.jin2003062.