PMID- 34645393
OWN - NLM
STAT- MEDLINE
DCOM- 20220310
LR  - 20220310
IS  - 1471-2369 (Electronic)
IS  - 1471-2369 (Linking)
VI  - 22
IP  - 1
DP  - 2021 Oct 13
TI  - Renal infarction associated with low dose intravenous immunoglobulin in a kidney 
      transplant recipient with sepsis: a case report and literature review.
PG  - 338
LID - 10.1186/s12882-021-02545-1 [doi]
LID - 338
AB  - BACKGROUND: The use of human intravenous immunoglobulin gamma (IVIG) is 
      associated with thromboembolic events as a complication. There are few reported 
      cases of renal infarction during IVIG use in the general population, but 
      transplant kidney may be more susceptible to thromboembolic events following IVIG 
      use. CASE PRESENTATION: A 41-year-old woman visited with fever and pain at the 
      transplant kidney. Six years ago, she underwent kidney transplantation from a 
      deceased donor. Laboratory and radiologic findings were compatible to septic 
      condition, secondary to acute pyelonephritis. We started antibiotics, inotropics, 
      and IVIG. The patient abruptly developed gross hematuria and urine output 
      decreased to 100 cc/day during IVIG administration. Renal doppler and pathologic 
      findings revealed renal infarction. Oliguria and azotemia persisted and she is 
      undergoing maintenance hemodialysis. CONCLUSION: Our case shows that infarction 
      of transplant kidney can be caused by IVIG use in a patient with severe 
      infection. Thus, when using IVIG for kidney transplant patients with high risk of 
      thromboembolic events, we may be careful to prevent the thromboembolic events.
CI  - (c) 2021. The Author(s).
FAU - Choi, Eun Woo
AU  - Choi EW
AD  - Division of Nephrology, Department of Internal Medicine, Dongkuk University 
      Medical Center, Gyeongju, Republic of Korea.
FAU - Do, Jun Young
AU  - Do JY
AD  - Division of Nephrology, Department of Internal Medicine, College of Medicine, 
      Yeungnam University, Daegu, Republic of Korea.
FAU - Kim, A Young
AU  - Kim AY
AD  - Division of Nephrology, Department of Internal Medicine, College of Medicine, 
      Yeungnam University, Daegu, Republic of Korea.
FAU - Kang, Seok Hui
AU  - Kang SH
AUID- ORCID: 0000-0003-1023-0195
AD  - Division of Nephrology, Department of Internal Medicine, College of Medicine, 
      Yeungnam University, Daegu, Republic of Korea. kangkang@ynu.ac.kr.
AD  - Department of Internal Medicine, Yeungnam University Medical Center, 317-1 
      Daemyung-Dong, Nam-Ku, Daegu, 705-717, South Korea. kangkang@ynu.ac.kr.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211013
PL  - England
TA  - BMC Nephrol
JT  - BMC nephrology
JID - 100967793
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/administration & dosage/*adverse effects
MH  - Infarction/*chemically induced
MH  - Kidney/*blood supply
MH  - *Kidney Transplantation
MH  - Postoperative Complications/*chemically induced
MH  - Sepsis/*complications
PMC - PMC8511279
OTO - NOTNLM
OT  - Intravenous immunoglobulin
OT  - Renal infarction
OT  - Thromboembolism
COIS- Nothing to declare.
EDAT- 2021/10/15 06:00
MHDA- 2022/03/11 06:00
PMCR- 2021/10/13
CRDT- 2021/10/14 05:27
PHST- 2020/11/30 00:00 [received]
PHST- 2021/09/28 00:00 [accepted]
PHST- 2021/10/14 05:27 [entrez]
PHST- 2021/10/15 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2021/10/13 00:00 [pmc-release]
AID - 10.1186/s12882-021-02545-1 [pii]
AID - 2545 [pii]
AID - 10.1186/s12882-021-02545-1 [doi]
PST - epublish
SO  - BMC Nephrol. 2021 Oct 13;22(1):338. doi: 10.1186/s12882-021-02545-1.