PMID- 34646826
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211015
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 9
DP  - 2021
TI  - The "Neuro-Glial-Vascular" Unit: The Role of Glia in Neurovascular Unit Formation 
      and Dysfunction.
PG  - 732820
LID - 10.3389/fcell.2021.732820 [doi]
LID - 732820
AB  - The neurovascular unit (NVU) is a complex multi-cellular structure consisting of 
      endothelial cells (ECs), neurons, glia, smooth muscle cells (SMCs), and 
      pericytes. Each component is closely linked to each other, establishing a 
      structural and functional unit, regulating central nervous system (CNS) blood 
      flow and energy metabolism as well as forming the blood-brain barrier (BBB) and 
      inner blood-retina barrier (BRB). As the name suggests, the "neuro" and 
      "vascular" components of the NVU are well recognized and neurovascular coupling 
      is the key function of the NVU. However, the NVU consists of multiple cell types 
      and its functionality goes beyond the resulting neurovascular coupling, with 
      cross-component links of signaling, metabolism, and homeostasis. Within the NVU, 
      glia cells have gained increased attention and it is increasingly clear that they 
      fulfill various multi-level functions in the NVU. Glial dysfunctions were shown 
      to precede neuronal and vascular pathologies suggesting central roles for glia in 
      NVU functionality and pathogenesis of disease. In this review, we take a 
      "glio-centric" view on NVU development and function in the retina and brain, how 
      these change in disease, and how advancing experimental techniques will help us 
      address unanswered questions.
CI  - Copyright (c) 2021 Kugler, Greenwood and MacDonald.
FAU - Kugler, Elisabeth C
AU  - Kugler EC
AD  - Institute of Ophthalmology, Faculty of Brain Sciences, University College London, 
      London, United Kingdom.
FAU - Greenwood, John
AU  - Greenwood J
AD  - Institute of Ophthalmology, Faculty of Brain Sciences, University College London, 
      London, United Kingdom.
FAU - MacDonald, Ryan B
AU  - MacDonald RB
AD  - Institute of Ophthalmology, Faculty of Brain Sciences, University College London, 
      London, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210927
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC8502923
OTO - NOTNLM
OT  - Muller glia
OT  - astrocytes
OT  - brain
OT  - neurovascular unit
OT  - retina
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/10/15 06:00
MHDA- 2021/10/15 06:01
PMCR- 2021/01/01
CRDT- 2021/10/14 06:39
PHST- 2021/06/29 00:00 [received]
PHST- 2021/09/01 00:00 [accepted]
PHST- 2021/10/14 06:39 [entrez]
PHST- 2021/10/15 06:00 [pubmed]
PHST- 2021/10/15 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcell.2021.732820 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2021 Sep 27;9:732820. doi: 10.3389/fcell.2021.732820. 
      eCollection 2021.