PMID- 34647262 OWN - NLM STAT- MEDLINE DCOM- 20220110 LR - 20220110 IS - 1940-6029 (Electronic) IS - 1064-3745 (Linking) VI - 2368 DP - 2022 TI - NASA's Ground-Based Microgravity Simulation Facility. PG - 281-299 LID - 10.1007/978-1-0716-1677-2_18 [doi] AB - Since opportunities to conduct experiments in space are scarce, various microgravity simulators and analogs have been widely used in space biology ground studies. Even though microgravity simulators do not produce all of the biological effects observed in the true microgravity environment, they provide alternative test platforms that are effective, affordable, and readily available to facilitate microgravity research. The Microgravity Simulation Support Facility (MSSF) at the National Aeronautics and Space Administration (NASA) John F. Kennedy Space Center (KSC) has been established for conducting short duration experiments, typically less than 1 month, utilizing a variety of microgravity simulation devices for research at different gravity levels. The simulators include, but are not limited to, 2D Clinostats, 3D Clinostats, Random Positioning Machines, and Rotating Wall Vessels. In this chapter, we will discuss current MSSF capabilities, development concepts, and the physical characteristics of these microgravity simulators. CI - (c) 2022. Springer Science+Business Media, LLC, part of Springer Nature. FAU - Zhang, Ye AU - Zhang Y AD - NASA John F. Kennedy Space Center, Merritt Island, FL, USA. ye.zhang-1@nasa.gov. FAU - Richards, Jeffery T AU - Richards JT AD - NASA John F. Kennedy Space Center, Merritt Island, FL, USA. AD - LASSO Contract, URS Federal Services, Inc., Germantown, MD, USA. FAU - Hellein, Jessica L AU - Hellein JL AD - NASA John F. Kennedy Space Center, Merritt Island, FL, USA. FAU - Johnson, Christina M AU - Johnson CM AD - NASA John F. Kennedy Space Center, Merritt Island, FL, USA. AD - Universities Space Research Association, Washington, DC, USA. FAU - Woodall, Julia AU - Woodall J AD - NASA John F. Kennedy Space Center, Merritt Island, FL, USA. FAU - Sorenson, Tait AU - Sorenson T AD - NASA John F. Kennedy Space Center, Merritt Island, FL, USA. FAU - Neelam, Srujana AU - Neelam S AD - NASA John F. Kennedy Space Center, Merritt Island, FL, USA. AD - Universities Space Research Association, Washington, DC, USA. FAU - Ruby, Anna Maria J AU - Ruby AMJ AD - NASA John F. Kennedy Space Center, Merritt Island, FL, USA. FAU - Levine, Howard G AU - Levine HG AD - NASA John F. Kennedy Space Center, Merritt Island, FL, USA. LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PL - United States TA - Methods Mol Biol JT - Methods in molecular biology (Clifton, N.J.) JID - 9214969 SB - IM MH - *Space Flight MH - United States MH - United States National Aeronautics and Space Administration MH - *Weightlessness MH - *Weightlessness Simulation OTO - NOTNLM OT - Facility OT - MSSF OT - Microgravity simulation OT - Plant research OT - Space biology EDAT- 2021/10/15 06:00 MHDA- 2022/01/11 06:00 CRDT- 2021/10/14 06:48 PHST- 2021/10/14 06:48 [entrez] PHST- 2021/10/15 06:00 [pubmed] PHST- 2022/01/11 06:00 [medline] AID - 10.1007/978-1-0716-1677-2_18 [doi] PST - ppublish SO - Methods Mol Biol. 2022;2368:281-299. doi: 10.1007/978-1-0716-1677-2_18.