PMID- 34647399
OWN - NLM
STAT- MEDLINE
DCOM- 20220512
LR  - 20220523
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 28
IP  - 3
DP  - 2022 Jun
TI  - Ascertaining minimal clinically meaningful changes in symptoms of depression 
      rated by the 15-item Centre for Epidemiologic Studies Depression Scale.
PG  - 500-506
LID - 10.1111/jep.13629 [doi]
AB  - RATIONALE, AIMS AND OBJECTIVES: In clinical practise and in clinical studies on 
      depression it is important to estimate whether changes in symptomatology measured 
      by self-rating instruments are, in fact, clinically relevant. Therefore, the aim 
      of the study was to estimate the clinical relevance of changes on the 15-item 
      version of the Centre for Epidemiologic Studies Depression Scale (CES-D-15) based 
      on the concept of the minimal clinically important difference (MCID). METHODS: 
      Data was acquired from 4781 patients with depression symptoms from a German 
      psychosomatic hospital who have been assessed using the CES-D-15 before and after 
      treatment. Threshold values representing the MCID were estimated on the basis of 
      mean change scores and sensitivity/specificity analyses. Patients' global 
      impression of change, clinical (therapists') global impression of change and 
      change in impairment severity were used as external anchor criteria. RESULTS: On 
      average, the MCID was represented by a reduction of approximately 11 points in 
      the CES-D-15, irrespective of age, gender, type of treatment and first or 
      secondary diagnosis. However, higher baseline scores in the CES-D-15 required 
      larger changes of raw values to represent a clinically important difference. 
      CONCLUSIONS: Anchor-based values are suggested here as an estimation of the 
      clinical relevance of changes in the CES-D-15. Thus, instead of relying solely on 
      effect sizes, the evaluation of treatment outcomes should be supplemented by 
      reporting the percentage of patients who have reached the MCID. Further 
      examinations to verify our results in other patient populations and with other 
      types of anchor criteria will be needed.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Haase, Ingo
AU  - Haase I
AUID- ORCID: 0000-0001-5699-7303
AD  - Department of Research, Development and Quality Assurance, Clinic Group 
      Enzensberg, Hopfen am See, Germany.
FAU - Winkeler, Markus
AU  - Winkeler M
AD  - Department of Psychosomatics and Psychotherapy, Parkland Clinic, Bad Wildungen, 
      Germany.
FAU - Imgart, Hartmut
AU  - Imgart H
AD  - Department of Psychosomatics and Psychotherapy, Parkland Clinic, Bad Wildungen, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20211013
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
MH  - *Depression/diagnosis/epidemiology
MH  - Epidemiologic Studies
MH  - Humans
MH  - *Minimal Clinically Important Difference
MH  - Sensitivity and Specificity
MH  - Treatment Outcome
OTO - NOTNLM
OT  - clinical significance
OT  - depression rating scale
OT  - minimal clinically important difference
OT  - minimal detectable change
OT  - outcome measurement
OT  - psychosomatic medicine
EDAT- 2021/10/15 06:00
MHDA- 2022/05/14 06:00
CRDT- 2021/10/14 06:57
PHST- 2021/09/22 00:00 [revised]
PHST- 2021/06/21 00:00 [received]
PHST- 2021/09/24 00:00 [accepted]
PHST- 2021/10/15 06:00 [pubmed]
PHST- 2022/05/14 06:00 [medline]
PHST- 2021/10/14 06:57 [entrez]
AID - 10.1111/jep.13629 [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2022 Jun;28(3):500-506. doi: 10.1111/jep.13629. Epub 2021 Oct 
      13.