PMID- 34648090
OWN - NLM
STAT- MEDLINE
DCOM- 20220215
LR  - 20220215
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 59
IP  - 2
DP  - 2022 Feb
TI  - The longitudinal effect of the atherogenic index of plasma on type 2 diabetes in 
      middle-aged and older Chinese.
PG  - 269-279
LID - 10.1007/s00592-021-01801-y [doi]
AB  - AIMS: Atherogenic Index of Plasma (AIP) has been proposed as a novel marker of 
      plasma atherogenicity, but its longitudinal predictive value in type 2 diabetes 
      mellitus (T2DM) remains unclear. We aimed to assess the associations of AIP and 
      its longitudinal transition with T2DM among middle-aged and older Chinese. 
      METHODS: Data were extracted from four rounds of the China Health and Retirement 
      Longitudinal Study (2011, 2013, 2015, and 2018). AIP was calculated as log(10) 
      (triglyceride/high-density lipoprotein cholesterol). Participants were classified 
      into high and low AIP groups at baseline, and subsequently into four transition 
      patterns during follow-up: maintained-high, maintained-low, high-to-low, and 
      low-to-high AIP. Multivariable Cox frailty models were applied to explore the 
      longitudinal transition patterns of AIP on the development of T2DM. RESULTS: A 
      total of 8760 subjects without T2DM were selected in 2011, of which 981 developed 
      T2DM until 2018. When compared with people with maintained-low AIP patterns, 
      those with transition patterns of maintained-high AIP, high-to-low AIP, and 
      low-to-high AIP were at around 1.5 times higher risk of T2DM (HR(adj) = 1.69, 
      1.32, and 1.47, respectively, all P < 0.05). However, the risk of T2DM did not 
      decrease in the high-to-low AIP group as compared to the maintained-high AIP 
      group. CONCLUSIONS: Three longitudinal AIP transition patterns (maintained-high 
      AIP, high-to-low AIP, and low-to-high AIP) were associated with the development 
      of T2DM. Preventions are needed to combat T2DM at an early dyslipidemic stage.
CI  - (c) 2021. Springer-Verlag Italia S.r.l., part of Springer Nature.
FAU - Yi, Qian
AU  - Yi Q
AD  - School of Public Health and Women's Hospital, Zhejiang University School of 
      Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
FAU - Ren, Ziyang
AU  - Ren Z
AD  - School of Public Health and Women's Hospital, Zhejiang University School of 
      Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
FAU - Bai, Guannan
AU  - Bai G
AD  - Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 
      China.
FAU - Zhu, Siyu
AU  - Zhu S
AD  - School of Public Health and Women's Hospital, Zhejiang University School of 
      Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
FAU - Li, Shuting
AU  - Li S
AD  - School of Public Health and Women's Hospital, Zhejiang University School of 
      Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
FAU - Li, Chunlu
AU  - Li C
AD  - Medical School, University of Edinburgh, Edinburgh, UK.
FAU - Wu, Hongjiang
AU  - Wu H
AD  - Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Prince of Wales Hospital, Hong Kong Special Administrative Region, China.
FAU - Zhu, Yimin
AU  - Zhu Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang 
      University School of Medicine, Hangzhou, 310058, China. zhuym@zju.edu.cn.
FAU - Song, Peige
AU  - Song P
AUID- ORCID: 0000-0002-0196-9759
AD  - School of Public Health and Women's Hospital, Zhejiang University School of 
      Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang, China. 
      peigesong@zju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20211014
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Aged
MH  - China/epidemiology
MH  - Cholesterol, HDL
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Humans
MH  - Longitudinal Studies
MH  - Middle Aged
MH  - Risk Factors
MH  - Triglycerides
OTO - NOTNLM
OT  - Atherogenic Index of Plasma
OT  - Cohort study
OT  - Type 2 diabetes mellitus
EDAT- 2021/10/15 06:00
MHDA- 2022/02/16 06:00
CRDT- 2021/10/14 12:28
PHST- 2021/07/24 00:00 [received]
PHST- 2021/09/06 00:00 [accepted]
PHST- 2021/10/15 06:00 [pubmed]
PHST- 2022/02/16 06:00 [medline]
PHST- 2021/10/14 12:28 [entrez]
AID - 10.1007/s00592-021-01801-y [pii]
AID - 10.1007/s00592-021-01801-y [doi]
PST - ppublish
SO  - Acta Diabetol. 2022 Feb;59(2):269-279. doi: 10.1007/s00592-021-01801-y. Epub 2021 
      Oct 14.