PMID- 34648979
OWN - NLM
STAT- MEDLINE
DCOM- 20220830
LR  - 20221207
IS  - 1877-0665 (Electronic)
IS  - 1877-0657 (Linking)
VI  - 65
IP  - 5
DP  - 2022 Sep
TI  - Effect of high-intensity interval training protocols on VO(2)max and HbA1c level 
      in people with type 2 diabetes: A systematic review and meta-analysis.
PG  - 101586
LID - S1877-0657(21)00104-4 [pii]
LID - 10.1016/j.rehab.2021.101586 [doi]
AB  - BACKGROUND: The effect of high-intensity interval training (HIIT) protocols 
      according to different work intervals, session volumes and training periods has 
      not been evaluated in patients with type 2 diabetes mellitus (T2DM). OBJECTIVE: 
      This was a systematic review and meta-analysis of the effect of HIIT and its 
      different protocols compared to moderate-intensity continuous training (MICT) and 
      the control group on VO(2)max and glycated hemoglobin (HbA1c) level in patients 
      with T2DM. METHODS: The search strategy considered studies published up to 
      September 2020 in the databases MEDLINE (PubMed), EMBASE, Cochrane CENTRAL, Web 
      of Science and SPORTDiscus. Two authors independently searched the selected 
      databases for randomized clinical trials that compared HIIT to MICT or the 
      control in adults with T2DM. A random-effects meta-analysis was performed and the 
      data are presented as the mean difference (95% confidence intervals [95% CIs]) 
      between HIIT, MICT and control groups. RESULTS: A total of 20 studies (738 
      participants) were included. Overall, HIIT increased VO(2)max by 5.09 mL/kg/min 
      (95% CI 2.99; 7.19, I(2) = 80.89) versus the control and by 1.9 mL/kg/min (95% CI 
      0.81; 2.98, I(2) = 25.62) versus MICT. HIIT promoted a significant reduction in 
      HbA1c level of -0.8% (95% CI -1.06; -0.49, I(2) = 77.31) versus the control but 
      with no difference versus MICT. Moderate-interval, high-volume and long-term 
      training promoted a greater increase in VO(2)max. A long interval and moderate 
      volume and period conferred a greater increase in VO(2)max versus MICT. A short 
      interval and moderate volume and period conferred a greater reduction in HbA1c 
      level versus the control. No publication bias was detected, as evaluated by a 
      funnel chart and Egger's test (p > 0.05). CONCLUSIONS: As compared with MICT, 
      HIIT had better effect on VO(2)max and a similar effect on HbA1C level. Interval 
      protocols, moderate to long training period and moderate to high volume may 
      maximize the HIIT effect in patients with T2DM.
CI  - Copyright (c) 2021 Elsevier Masson SAS. All rights reserved.
FAU - de Mello, Mariana Brondani
AU  - de Mello MB
AD  - Postgraduate Program in Functional Rehabilitation, Federal University of Santa 
      Maria, Santa Maria, Brazil.
FAU - Righi, Natiele Camponogara
AU  - Righi NC
AD  - Postgraduate Program in Rehabilitation Sciences at the Federal University of 
      Health Sciences of Porto Alegre, Porto Alegre, Brazil.
FAU - Schuch, Felipe Barreto
AU  - Schuch FB
AD  - Department of Sports Methods and Techniques, Federal University of Santa Maria, 
      Santa Maria, Brazil; Department of Physiotherapy and Rehabilitation, 
      Post-Graduate Programme in Functional Rehabilitation, Federal University of Santa 
      Maria, Santa Maria, Brazil.
FAU - Signori, Luis Ulisses
AU  - Signori LU
AD  - Department of Physiotherapy and Rehabilitation, Post-Graduate Programme in 
      Functional Rehabilitation, Federal University of Santa Maria, Santa Maria, 
      Brazil.
FAU - da Silva, Antonio Marcos Vargas
AU  - da Silva AMV
AD  - Department of Physiotherapy and Rehabilitation, Post-Graduate Programme in 
      Functional Rehabilitation, Federal University of Santa Maria, Santa Maria, 
      Brazil. Electronic address: antonio.77@terra.com.br.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20211119
PL  - Netherlands
TA  - Ann Phys Rehabil Med
JT  - Annals of physical and rehabilitation medicine
JID - 101502773
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adult
MH  - *Diabetes Mellitus, Type 2
MH  - Glycated Hemoglobin
MH  - *High-Intensity Interval Training
MH  - Humans
OTO - NOTNLM
OT  - Cardiorespiratory fitness
OT  - Glycated hemoglobin
OT  - High-intensity interval training
OT  - Meta-analysis
OT  - Type 2 diabetes
COIS- Declaration of Competing Interest None declared.
EDAT- 2021/10/15 06:00
MHDA- 2022/08/31 06:00
CRDT- 2021/10/14 20:14
PHST- 2021/02/02 00:00 [received]
PHST- 2021/07/19 00:00 [revised]
PHST- 2021/08/10 00:00 [accepted]
PHST- 2021/10/15 06:00 [pubmed]
PHST- 2022/08/31 06:00 [medline]
PHST- 2021/10/14 20:14 [entrez]
AID - S1877-0657(21)00104-4 [pii]
AID - 10.1016/j.rehab.2021.101586 [doi]
PST - ppublish
SO  - Ann Phys Rehabil Med. 2022 Sep;65(5):101586. doi: 10.1016/j.rehab.2021.101586. 
      Epub 2021 Nov 19.