PMID- 34649251
OWN - NLM
STAT- MEDLINE
DCOM- 20221021
LR  - 20221021
IS  - 1423-0259 (Electronic)
IS  - 0030-3747 (Linking)
VI  - 65
IP  - 5
DP  - 2022
TI  - Retina Vascular Structures near the Optic Disc and in the Macula in Primary 
      Angle-Closure Suspects.
PG  - 575-583
LID - 10.1159/000520030 [doi]
AB  - INTRODUCTION: The main aim of this article was to study the retinal peripapillary 
      and macular vascular structures in eyes with primary angle-closure suspects 
      (PACS) using optical coherence tomography angiography (OCTA). METHODS: In this 
      cross-sectional study, control and PACS subjects were recruited from a community 
      screening. Only one eye per subject was used for analysis. All participants 
      underwent a questionnaire survey, physical and ophthalmic examinations, ocular 
      biometry measurements, and OCTA. We compared basic demographics and vessel 
      structure parameters between control and PACS eyes. Univariate and multivariate 
      linear regression analyses were performed to investigate factors associated with 
      vascular parameters in both groups. RESULTS: Data from 254 subjects including 155 
      PACS and 99 controls were analyzed. In the peripapillary region, PACS eyes showed 
      similar retina nerve fiber layer (RNFL) and vessel densities (VDs) including and 
      excluding large vessels compared to control eyes. Compared to control eyes, all 
      macular OCTA parameters showed significant differences in PACS eyes, including 
      decreased superficial VD (p = 0.006) and deep VD (p = 0.004), larger fovea 
      avascular zone (FAZ) area (p = 0.006), and longer FAZ perimeter (p = 0.004). 
      Gender (p = 0.039), age (p < 0.001), and Garway-Heath superior hemisphere RNFL (p 
      < 0.001) were risk factors influencing optic disc VD excluding large vessels. 
      Axial length was the major factor affecting macula superficial and deep VDs (p = 
      0.004 and 0.001 respectively), while PACS was an independent factor associated 
      with larger FAZ perimeter (p = 0.046). CONCLUSION: While PACS and control eyes 
      have comparable RNFL and vascular structure around the optic nerve head, macular 
      vascular structures are significantly different.
CI  - (c) 2021 The Author(s). Published by S. Karger AG, Basel.
FAU - Pan, Xiaohua
AU  - Pan X
AD  - Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Beijing, China, katepan1212@163.com.
AD  - Shenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, Shenzhen, China, 
      katepan1212@163.com.
FAU - Ruan, Merry Z C
AU  - Ruan MZC
AD  - Department of Ophthalmology, University of California San Francisco, San 
      Francisco, California, USA.
FAU - Fan, Wudi
AU  - Fan W
AD  - Department of Ophthalmology, University of California San Francisco, San 
      Francisco, California, USA.
AD  - College of Engineering, University of California, Berkeley, California, USA.
FAU - Cao, Kai
AU  - Cao K
AD  - Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Beijing, China.
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Capital Medical University, Beijing, China.
FAU - Feng, Hui
AU  - Feng H
AD  - Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Beijing, China.
FAU - Hu, Zhongyin
AU  - Hu Z
AD  - Department of Ophthalmology, First People's Hospital of Yunnan Province, Kunming, 
      China.
FAU - Yang, Yue
AU  - Yang Y
AD  - Department of Ophthalmology, The Third Hospital of Mianyang, Sichuan Mental 
      Health Center, Mianyang, China.
FAU - Yan, Fancheng
AU  - Yan F
AD  - Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical 
      University, Beijing, China.
FAU - Zhao, Mengya
AU  - Zhao M
AD  - Department of Ophthalmology, Shanghai General Hospital, Shanghai, China.
FAU - Liu, Qian
AU  - Liu Q
AD  - Henan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital and 
      Zhengzhou University People's Hospital, Zhengzhou, China.
FAU - Fu, Min
AU  - Fu M
AD  - Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Xiang, Fei
AU  - Xiang F
AD  - Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Beijing, China.
FAU - Lee, Richard
AU  - Lee R
AD  - Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 
      Miami, Florida, USA.
FAU - Li, Shuning
AU  - Li S
AD  - Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Beijing, China.
FAU - Han, Ying
AU  - Han Y
AD  - Department of Ophthalmology, University of California San Francisco, San 
      Francisco, California, USA.
AD  - Ophthalmology Section, Surgical Service, San Francisco Veterans Affairs Medical 
      Center, San Francisco, California, USA.
LA  - eng
PT  - Journal Article
DEP - 20211014
PL  - Switzerland
TA  - Ophthalmic Res
JT  - Ophthalmic research
JID - 0267442
SB  - IM
MH  - Humans
MH  - Cross-Sectional Studies
MH  - *Macula Lutea/blood supply/diagnostic imaging
MH  - *Optic Disk/blood supply/diagnostic imaging
MH  - Retinal Vessels/diagnostic imaging
MH  - Tomography, Optical Coherence/methods
MH  - Angiography/methods
OTO - NOTNLM
OT  - Fovea avascular zone
OT  - Optical coherence tomography angiography
OT  - Primary angle-closure suspect
OT  - Vessel density
EDAT- 2021/10/15 06:00
MHDA- 2022/10/20 06:00
CRDT- 2021/10/14 20:30
PHST- 2021/05/05 00:00 [received]
PHST- 2021/09/24 00:00 [accepted]
PHST- 2021/10/15 06:00 [pubmed]
PHST- 2022/10/20 06:00 [medline]
PHST- 2021/10/14 20:30 [entrez]
AID - 000520030 [pii]
AID - 10.1159/000520030 [doi]
PST - ppublish
SO  - Ophthalmic Res. 2022;65(5):575-583. doi: 10.1159/000520030. Epub 2021 Oct 14.