PMID- 34650022
OWN - NLM
STAT- MEDLINE
DCOM- 20211126
LR  - 20230924
IS  - 1473-5733 (Electronic)
IS  - 0957-5235 (Linking)
VI  - 32
IP  - 7
DP  - 2021 Oct 1
TI  - Evaluation of the activated partial thromboplastin time and its influential 
      factors in ischemic heart disease patients under heparin treatment.
PG  - 496-503
LID - 10.1097/MBC.0000000000001088 [doi]
AB  - This study aimed to detect the defects of the current methods used to monitor 
      unfractionated heparin (UFH) anticoagulant effect and find possible assistive 
      parameters for activated partial thromboplastin time (aPTT) test to improve 
      treatment performance. The required information was gathered from patients' case 
      records, treatment charts and laboratory reports. Kendall's tau correlation 
      coefficient was calculated for analysing the relationship between variables. The 
      partial least squares (PLS) and the stepwise multiple regression were operated, 
      and the area under the receiver operating characteristic curve (AUC) and the 
      r-squared (r2) were used to show the analytical ability of the models, 
      respectively. Overall, 102 UFH-receiving ischemic heart disease patients 
      participated in this study. The aPTT value varied from 30 to 95 s 
      (mean +/- SD = 44 +/- 14). Therapeutic aPTT values were observed in 15% of 
      hospitalization days. The aPTT value showed statistically significant 
      correlations with mean UFH infusion (U/kg/h), age, prothrombin time (PT), 
      smoking, international normalized ratio, haemoglobin (Hgb) and blood triglyceride 
      level. Triglyceride level and PT were efficacious predictors of aPTT value 
      (P < 0.001, r2 = 0.336). Moreover, blood urea nitrogen (BUN) and blood creatinine 
      (Cr) levels were the best predictors for mortality. The mean BUN/Cr ratio was 
      18 +/- 5 and 25 +/- 12 in nonexpired and expired subjects, respectively. If 
      calibrated institution-specific therapeutic aPTT ranges and updated weight-based 
      UFH nomograms get employed, aPTT test, along with the BUN/Cr ratio and Hgb level, 
      as assistive parameters for predicting haemorrhagic incidents, would be near 
      ideal monitoring method in UFH-receiving patients.
CI  - Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Rezagholizadeh, Afra
AU  - Rezagholizadeh A
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy.
FAU - Adib, Zainab-Kubra
AU  - Adib ZK
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy.
FAU - Entezari-Maleki, Taher
AU  - Entezari-Maleki T
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy.
AD  - Cardiovascular Research Centre, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Blood Coagul Fibrinolysis
JT  - Blood coagulation & fibrinolysis : an international journal in haemostasis and 
      thrombosis
JID - 9102551
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticoagulants/*therapeutic use
MH  - Blood Coagulation/*drug effects
MH  - Female
MH  - Heparin/*therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*blood/drug therapy
MH  - Partial Thromboplastin Time
MH  - Prospective Studies
EDAT- 2021/10/16 06:00
MHDA- 2021/11/27 06:00
CRDT- 2021/10/15 05:43
PHST- 2021/10/15 05:43 [entrez]
PHST- 2021/10/16 06:00 [pubmed]
PHST- 2021/11/27 06:00 [medline]
AID - 00001721-202110000-00010 [pii]
AID - 10.1097/MBC.0000000000001088 [doi]
PST - ppublish
SO  - Blood Coagul Fibrinolysis. 2021 Oct 1;32(7):496-503. doi: 
      10.1097/MBC.0000000000001088.