PMID- 34651003
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211016
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 8
DP  - 2021
TI  - Intrinsic Capacity vs. Multimorbidity: A Function-Centered Construct Predicts 
      Disability Better Than a Disease-Based Approach in a Community-Dwelling Older 
      Population Cohort.
PG  - 753295
LID - 10.3389/fmed.2021.753295 [doi]
LID - 753295
AB  - Objective: This study aimed to assess the status of intrinsic capacity (IC)-a 
      novel function-centered construct proposed by the WHO and examine whether 
      impairment in IC predicts subsequent 1-year activities of daily living (ADL) 
      disability better than a disease-based approach, i. e., multimorbidity status. 
      Methods: This study included data of community-dwelling older adults from the 
      Beijing Longitudinal Study on Aging II aged 65 years or older who were followed 
      up at 1 year. Multivariate logistic regressions were performed to estimate the 
      odds of ADL disability at baseline and 1-year follow-up. Results: A total of 
      7,298 older participants aged 65 years or older were included in the current 
      study. About 4,742 older adults were followed up at 1 year. At baseline, subjects 
      with a higher impairment in IC domains showed higher odds of ADL disability [adj. 
      odds ratio (OR) = 9.51 for impairment in >/=3 domains, area under the curve (AUC) = 
      0.751] compared to much lower odds of ADL disability in subjects with a higher 
      number (>/=3) of chronic diseases (adj. OR 3.92, AUC = 0.712). At 1-year follow-up, 
      the overall incidence of ADL disability increased with the impairment in IC 
      domains higher than the increase in multimorbidity status. A higher impairment in 
      IC domains showed higher odds of incidence ADL disability for impairment in 2 or 
      >/=3 IC domains (adj. OR 2.32 for impairment in >/=3 domains, adj. OR 1.43 for 
      impairment in two domains, AUC = 0.685). Only subjects who had >/=3 chronic 
      diseases had higher odds of 1-year incident ADL disability (adj. OR 1.73, AUC = 
      0.681) that was statistically significant. Conclusion: Our results imply that a 
      function-centered construct could have higher predictability of disability 
      compared to the multimorbidity status in community older people. Our results need 
      to be confirmed by studies with longer follow-up.
CI  - Copyright (c) 2021 Zhao, Chhetri, Chang, Zheng, Ma and Chan.
FAU - Zhao, Jing
AU  - Zhao J
AD  - Department of Geriatrics, Neurology and Neurobiology, National Clinical Research 
      Center for Geriatric Disease, Xuanwu Hospital of Capital Medical University, 
      Beijing, China.
FAU - Chhetri, Jagadish K
AU  - Chhetri JK
AD  - Department of Geriatrics, Neurology and Neurobiology, National Clinical Research 
      Center for Geriatric Disease, Xuanwu Hospital of Capital Medical University, 
      Beijing, China.
FAU - Chang, Yi
AU  - Chang Y
AD  - Department of Respiration, Xuanwu Hospital of Capital Medical University, 
      Beijing, China.
FAU - Zheng, Zheng
AU  - Zheng Z
AD  - Department of Geriatrics, Neurology and Neurobiology, National Clinical Research 
      Center for Geriatric Disease, Xuanwu Hospital of Capital Medical University, 
      Beijing, China.
FAU - Ma, Lina
AU  - Ma L
AD  - Department of Geriatrics, Neurology and Neurobiology, National Clinical Research 
      Center for Geriatric Disease, Xuanwu Hospital of Capital Medical University, 
      Beijing, China.
FAU - Chan, Piu
AU  - Chan P
AD  - Department of Geriatrics, Neurology and Neurobiology, National Clinical Research 
      Center for Geriatric Disease, Xuanwu Hospital of Capital Medical University, 
      Beijing, China.
AD  - Key Laboratory for Neurodegenerative Disease of the Ministry of Education, 
      Beijing Key Laboratory for Parkinson's Disease, Parkinson Disease Center of 
      Beijing Institute for Brain Disorders, Beijing, China.
AD  - Clinical Center for Parkinson's Disease, Capital Medical University, Beijing, 
      China.
AD  - Advanced Innovation Center for Human Brain Protection, Capital Medical 
      University, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20210928
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC8505775
OTO - NOTNLM
OT  - ICOPE
OT  - aging
OT  - comorbidity
OT  - integrated care
OT  - older Chinese
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/10/16 06:00
MHDA- 2021/10/16 06:01
PMCR- 2021/09/28
CRDT- 2021/10/15 06:39
PHST- 2021/08/04 00:00 [received]
PHST- 2021/08/30 00:00 [accepted]
PHST- 2021/10/15 06:39 [entrez]
PHST- 2021/10/16 06:00 [pubmed]
PHST- 2021/10/16 06:01 [medline]
PHST- 2021/09/28 00:00 [pmc-release]
AID - 10.3389/fmed.2021.753295 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2021 Sep 28;8:753295. doi: 10.3389/fmed.2021.753295. 
      eCollection 2021.