PMID- 34651353
OWN - NLM
STAT- MEDLINE
DCOM- 20220510
LR  - 20220510
IS  - 1443-1661 (Electronic)
IS  - 0915-5635 (Linking)
VI  - 34
IP  - 4
DP  - 2022 May
TI  - Endoscopic management of gastroesophageal reflux disease: Panacea for proton pump 
      inhibitors dependent/refractory patients.
PG  - 687-699
LID - 10.1111/den.14169 [doi]
AB  - Endoscopic therapies in proton pump inhibitors (PPI) dependent/refractory 
      gastroesophageal reflux disease (GERD) are increasingly indicated in patients who 
      are not suitable or willing for chronic medical therapy and surgical 
      fundoplication. Currently available endoluminal anti-reflux procedures include 
      radiofrequency therapy (Stretta), suturing/plication and mucosal 
      ablation/resection techniques at the gastroesophageal junction. Meticulous work 
      up and patient selection results in a favorable outcome with these endoscopic 
      therapies, especially the quality of life and partially the PPI independence. 
      Stretta can be considered in patients with PPI refractory GERD and might have a 
      role in patients with reflux hypersensitivity and functional heartburn. 
      Endoscopic fundoplication using the Esophyx device and the GERD-X device have 
      strong evidence (multiple randomized controlled trials) in patients with small 
      hiatus hernia and high volume reflux episodes. Mucosal resection/ablation 
      techniques like anti-reflux mucosectomy and anti-reflux mucosal ablation have 
      shown promising results but need long term follow-up studies to prove their 
      efficacy. The subset of PPI dependent GERD population will benefit from 
      endoscopic therapies and the future of endoscopic management of GERD looks 
      promising.
CI  - (c) 2021 Japan Gastroenterological Endoscopy Society.
FAU - Kalapala, Rakesh
AU  - Kalapala R
AUID- ORCID: 0000-0003-3203-7708
AD  - Asian Institute of Gastroenterology, Hyderabad, India.
FAU - Singla, Neeraj
AU  - Singla N
AD  - Asian Institute of Gastroenterology, Hyderabad, India.
FAU - Reddy, Duvvur Nageshwar
AU  - Reddy DN
AD  - Asian Institute of Gastroenterology, Hyderabad, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211108
PL  - Australia
TA  - Dig Endosc
JT  - Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy 
      Society
JID - 9101419
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Fundoplication
MH  - *Gastroesophageal Reflux/surgery
MH  - Humans
MH  - *Proton Pump Inhibitors/therapeutic use
MH  - Quality of Life
MH  - Treatment Outcome
OTO - NOTNLM
OT  - PPI dependent GERD
OT  - endotherapy
OT  - gastroesophageal reflux
OT  - refractory GERD
EDAT- 2021/10/16 06:00
MHDA- 2022/05/11 06:00
CRDT- 2021/10/15 06:51
PHST- 2021/10/06 00:00 [revised]
PHST- 2021/04/29 00:00 [received]
PHST- 2021/10/12 00:00 [accepted]
PHST- 2021/10/16 06:00 [pubmed]
PHST- 2022/05/11 06:00 [medline]
PHST- 2021/10/15 06:51 [entrez]
AID - 10.1111/den.14169 [doi]
PST - ppublish
SO  - Dig Endosc. 2022 May;34(4):687-699. doi: 10.1111/den.14169. Epub 2021 Nov 8.