PMID- 34652354
OWN - NLM
STAT- MEDLINE
DCOM- 20220302
LR  - 20220531
IS  - 1759-9679 (Electronic)
IS  - 1759-9660 (Linking)
VI  - 13
IP  - 42
DP  - 2021 Nov 4
TI  - Rapid determination of sulfamethoxazole and trimethoprim illegally added to 
      health products using excitation-emission matrix fluorescence coupled with the 
      second-order calibration method.
PG  - 5075-5084
LID - 10.1039/d1ay01391b [doi]
AB  - In this work, a simple and fast analytical method based on a self-weighted 
      alternating trilinear decomposition (SWATLD) algorithm coupled with 
      excitation-emission matrix (EEM) fluorescence was developed for the simultaneous 
      determination of sulfamethoxazole (SMZ) and trimethoprim (TMP) illegally added to 
      health products. With the second-order advantage, the proposed method obtained 
      satisfactory results in the presence of peak overlap and unknown interferences. 
      The analysis time for a single sample is only 0.8 minutes. The average spiked 
      recoveries of SMZ and TMP in three health product spiked samples were in the 
      range of 91.0-106.2% and 86.8-107.8%, respectively. The relative standard 
      deviations (RSDs) were lower than 8.6%. In addition, verification parameters 
      including sensitivity (SEN), selectivity (SEL), the limit of detection (LOD), the 
      limit of quantification (LOQ), intra-day precision, and inter-day precision were 
      calculated, and the results show that the proposed method is feasible. The 
      quantitative results of the proposed method were further confirmed by the 
      LC-MS/MS method, which proved that the proposed method was efficient and green 
      for drug-abuse monitoring of SMZ and TMP in health products.
FAU - Chen, Lu-Zhu
AU  - Chen LZ
AD  - State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry 
      and Chemical Engineering, Hunan University, Changsha 410082, China. 
      hlwu@hnu.edu.cn.
FAU - Wu, Hai-Long
AU  - Wu HL
AUID- ORCID: 0000-0003-4483-2557
AD  - State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry 
      and Chemical Engineering, Hunan University, Changsha 410082, China. 
      hlwu@hnu.edu.cn.
FAU - Long, Wan-Jun
AU  - Long WJ
AD  - State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry 
      and Chemical Engineering, Hunan University, Changsha 410082, China. 
      hlwu@hnu.edu.cn.
FAU - Wang, Tong
AU  - Wang T
AD  - State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry 
      and Chemical Engineering, Hunan University, Changsha 410082, China. 
      hlwu@hnu.edu.cn.
FAU - Tong, Gao-Yan
AU  - Tong GY
AD  - State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry 
      and Chemical Engineering, Hunan University, Changsha 410082, China. 
      hlwu@hnu.edu.cn.
FAU - Yu, Ru-Qin
AU  - Yu RQ
AUID- ORCID: 0000-0001-9440-8899
AD  - State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry 
      and Chemical Engineering, Hunan University, Changsha 410082, China. 
      hlwu@hnu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211104
PL  - England
TA  - Anal Methods
JT  - Analytical methods : advancing methods and applications
JID - 101519733
RN  - AN164J8Y0X (Trimethoprim)
RN  - JE42381TNV (Sulfamethoxazole)
SB  - IM
MH  - Calibration
MH  - Chromatography, Liquid
MH  - Spectrometry, Fluorescence/methods
MH  - Sulfamethoxazole/*analysis/chemistry
MH  - *Tandem Mass Spectrometry
MH  - *Trimethoprim/analysis/chemistry
EDAT- 2021/10/16 06:00
MHDA- 2022/03/03 06:00
CRDT- 2021/10/15 12:33
PHST- 2021/10/16 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/10/15 12:33 [entrez]
AID - 10.1039/d1ay01391b [doi]
PST - epublish
SO  - Anal Methods. 2021 Nov 4;13(42):5075-5084. doi: 10.1039/d1ay01391b.