PMID- 34653600
OWN - NLM
STAT- MEDLINE
DCOM- 20220225
LR  - 20220225
IS  - 1873-4847 (Electronic)
IS  - 0955-2863 (Linking)
VI  - 100
DP  - 2022 Feb
TI  - The effect of coffee consumption on glucose homeostasis and redox-inflammatory 
      responses in high-fat diet-induced obese rats.
PG  - 108881
LID - S0955-2863(21)00301-6 [pii]
LID - 10.1016/j.jnutbio.2021.108881 [doi]
AB  - Coffee effects on glucose homeostasis in obesity remain controversial. We 
      investigated whether coffee mitigates the negative effects on glucose metabolism 
      induced by a high-fat diet and the interrelationships with redox-inflammatory 
      responses. Rats were treated with: control (CT-); coffee (CT+) 3.9 g of 
      freeze-dried coffee/kg of diet; high-fat (HF-); or high-fat + coffee 3.9 g of 
      freeze-dried coffee/kg of diet (HF+) diet. The high-fat diet increased weight 
      gain, feed efficiency, HOMA beta, muscle and hepatic glycogen, intestinal CAT and 
      SOD activity, hepatic protein (CARB) and lipid oxidation (MDA), muscle Prkaa1 
      mRNA and IL6 levels, and decreased food intake, hepatic GR, GPX and SOD 
      activities, intestinal CARB, intestinal Slc2a2 and Slc5a1 and hepatic Prkaa1 and 
      Prkaa2 mRNA levels, hepatic glucose-6-phosphatase and muscle hexokinase (HK) 
      activities, compared to the control diet. The high-fat diet with coffee increased 
      hepatic GST activity and TNF and decreased IL6 and intestinal glucosidase 
      activity compared with the high-fat diet. The coffee diet increased muscle 
      glycogen, hepatic CARB and PEPCK activity, and decreased hepatic GR and SOD 
      activities and intestinal CARB, compared with the control diet. Coffee increased 
      insulin levels, HOMA IR/beta, FRAP, muscle Prkaa1 mRNA levels and hepatic and muscle 
      phosphofructokinase-1, and it decreased intestinal CAT, hepatic Slc2a2 mRNA 
      levels and muscle HK activity, regardless of the diet type. In conclusion, 
      chronic coffee consumption improves antioxidant and anti-inflammatory responses, 
      but does not ameliorate glucose homeostasis in a high-fat diet-induced obesity 
      model. In addition, coffee consumption increases insulin secretion and promotes 
      muscle glycogen synthesis in rats maintained on a control diet.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Ramos, Larissa Valadares
AU  - Ramos LV
AD  - Postgraduate Program in Human Nutrition, Faculty of Health Sciences, Campus 
      Universitario Darcy Ribeiro, Universidade de Brasilia, Brasilia, Brazil. 
      Electronic address: lari_vr16@hotmail.com.
FAU - da Costa, Teresa Helena Macedo
AU  - da Costa THM
AD  - Postgraduate Program in Human Nutrition, Faculty of Health Sciences, Campus 
      Universitario Darcy Ribeiro, Universidade de Brasilia, Brasilia, Brazil.
FAU - Arruda, Sandra Fernandes
AU  - Arruda SF
AD  - Postgraduate Program in Human Nutrition, Faculty of Health Sciences, Campus 
      Universitario Darcy Ribeiro, Universidade de Brasilia, Brasilia, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211012
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Coffee)
RN  - 0 (Cytokines)
RN  - 0 (Insulin)
RN  - 9005-79-2 (Glycogen)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Blood Glucose/*metabolism
MH  - Carbohydrate Metabolism
MH  - *Coffee
MH  - Cytokines/blood
MH  - *Diet, High-Fat
MH  - Glycogen/biosynthesis
MH  - Homeostasis
MH  - Inflammation/*metabolism
MH  - Insulin/blood
MH  - Intestine, Small/metabolism
MH  - Liver/metabolism
MH  - Male
MH  - Muscle, Skeletal/metabolism
MH  - Obesity/*metabolism
MH  - Oxidation-Reduction
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - coffee
OT  - glucose
OT  - inflammation
OT  - insulin
OT  - obesity
OT  - redox
COIS- Declaration of competing interests The authors declare no conflict of interest.
EDAT- 2021/10/16 06:00
MHDA- 2022/02/26 06:00
CRDT- 2021/10/15 20:15
PHST- 2021/03/24 00:00 [received]
PHST- 2021/07/28 00:00 [revised]
PHST- 2021/09/20 00:00 [accepted]
PHST- 2021/10/16 06:00 [pubmed]
PHST- 2022/02/26 06:00 [medline]
PHST- 2021/10/15 20:15 [entrez]
AID - S0955-2863(21)00301-6 [pii]
AID - 10.1016/j.jnutbio.2021.108881 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2022 Feb;100:108881. doi: 10.1016/j.jnutbio.2021.108881. Epub 
      2021 Oct 12.