PMID- 34655348 OWN - NLM STAT- MEDLINE DCOM- 20220318 LR - 20220323 IS - 1875-8312 (Electronic) IS - 1569-5794 (Print) IS - 1569-5794 (Linking) VI - 38 IP - 3 DP - 2022 Mar TI - Subclinical leaflet thrombosis after transcatheter aortic valve implantation: no association with left ventricular reverse remodeling at 1-year follow-up. PG - 695-705 LID - 10.1007/s10554-021-02438-2 [doi] AB - Hypo-attenuated leaflet thickening (HALT) of transcatheter aortic valves is detected on multidetector computed tomography (MDCT) and reflects leaflet thrombosis. Whether HALT affects left ventricular (LV) reverse remodeling, a favorable effect of LV afterload reduction after transcatheter aortic valve implantation (TAVI) is unknown. The aim of this study was to examine the association of HALT after TAVI with LV reverse remodeling. In this multicenter case-control study, patients with HALT on MDCT were identified, and patients without HALT were propensity matched for valve type and size, LV ejection fraction (LVEF), sex, age and time of scan. LV dimensions and function were assessed by transthoracic echocardiography before and 12 months after TAVI. Clinical outcomes (stroke or transient ischemic attack, heart failure hospitalization, new-onset atrial fibrillation, all-cause mortality) were recorded. 106 patients (age 81 +/- 7 years, 55% male) with MDCT performed 37 days [IQR 32-52] after TAVI were analyzed (53 patients with HALT and 53 matched controls). Before TAVI, all echocardiographic parameters were similar between the groups. At 12 months follow-up, patients with and without HALT showed a significant reduction in LV end-diastolic volume, LV end-systolic volume and LV mass index (from 125 +/- 37 to 105 +/- 46 g/m(2), p = 0.001 and from 127 +/- 35 to 101 +/- 27 g/m(2), p < 0.001, respectively, p for interaction = 0.48). Moreover, LVEF improved significantly in both groups. In addition, clinical outcomes were not statistically different. Improvement in LVEF and LV reverse remodeling at 12 months after TAVI were not limited by HALT. CI - (c) 2021. The Author(s). FAU - Kuneman, Jurrien H AU - Kuneman JH AUID- ORCID: 0000-0003-2162-2768 AD - Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. FAU - Singh, Gurpreet K AU - Singh GK AD - Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. FAU - Hansson, Nicolaj C AU - Hansson NC AD - Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark. FAU - Fusini, Laura AU - Fusini L AD - Department of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy. FAU - Poulsen, Steen H AU - Poulsen SH AD - Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark. FAU - Fortuni, Federico AU - Fortuni F AD - Department of Cardiology, Azienda Ospedaliero Universitaria Citta della Salute e della Scienza di Torino, Turin, Italy. FAU - Vollema, E Mara AU - Vollema EM AD - Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. FAU - Pedersen, Anders L D AU - Pedersen ALD AD - Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark. FAU - Annoni, Andrea D AU - Annoni AD AD - Department of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy. FAU - Norgaard, Bjarne L AU - Norgaard BL AD - Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark. FAU - Pontone, Gianluca AU - Pontone G AD - Department of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy. FAU - Ajmone Marsan, Nina AU - Ajmone Marsan N AD - Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. FAU - Delgado, Victoria AU - Delgado V AD - Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. FAU - Bax, Jeroen J AU - Bax JJ AD - Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. j.j.bax@lumc.nl. FAU - Knuuti, Juhani AU - Knuuti J AUID- ORCID: 0000-0003-3156-9593 AD - Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. AD - Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20211016 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 SB - IM MH - Aged MH - Aged, 80 and over MH - Aortic Valve/diagnostic imaging/surgery MH - *Aortic Valve Stenosis/complications/diagnostic imaging/surgery MH - Case-Control Studies MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Predictive Value of Tests MH - *Thrombosis/complications/etiology MH - *Transcatheter Aortic Valve Replacement/adverse effects MH - Treatment Outcome MH - Ventricular Function, Left MH - Ventricular Remodeling PMC - PMC8926967 OTO - NOTNLM OT - Aortic stenosis OT - Hypo-attenuated leaflet thickening OT - Left ventricular reverse remodeling OT - Multi-detector row computed tomography OT - Subclinical leaflet thrombosis OT - Transcatheter aortic valve implantation COIS- Dr. Knuuti received consultancy fees from GE Healthcare and AstraZeneca and speaker fees from GE Healthcare, Bayer, Lundbeck, Boehringer-Ingelheim and Merck, outside of the submitted work. Dr. Bax received speaker fees from Abbot Vascular. Dr. Delgado received speaker fees from Abbott Vascular, Edwards Lifesciences, GE Healthcare, MSD and Medtronic. Dr. Norgaard received institutional research grants from Siemens, Heartflow, and Edwards Lifesciences. Dr. Pontone received institutional research grant and fee from GE Healthcare, Boehringer, Bracco, Medtronic, Bayer and Heartflow. Dr. Ajmone Marsan received speaker fees from Abbot Vascular. The department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands has received unrestricted research grants from Bayer, Abbott Vascular, Medtronic, Biotronik, Boston Scientific, GE Healthcare and Edwards Lifesciences. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. EDAT- 2021/10/17 06:00 MHDA- 2022/03/19 06:00 PMCR- 2021/10/16 CRDT- 2021/10/16 12:07 PHST- 2021/07/27 00:00 [received] PHST- 2021/10/05 00:00 [accepted] PHST- 2021/10/17 06:00 [pubmed] PHST- 2022/03/19 06:00 [medline] PHST- 2021/10/16 12:07 [entrez] PHST- 2021/10/16 00:00 [pmc-release] AID - 10.1007/s10554-021-02438-2 [pii] AID - 2438 [pii] AID - 10.1007/s10554-021-02438-2 [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2022 Mar;38(3):695-705. doi: 10.1007/s10554-021-02438-2. Epub 2021 Oct 16.