PMID- 34655885
OWN - NLM
STAT- MEDLINE
DCOM- 20211110
LR  - 20211110
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 227
DP  - 2021 Dec 20
TI  - Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: 
      Interference with metabolism and immune regulation in mussel Mytilus 
      galloprovincialis.
PG  - 112904
LID - S0147-6513(21)01016-2 [pii]
LID - 10.1016/j.ecoenv.2021.112904 [doi]
AB  - Both immune regulation and endocrine systems are great challenges to marine 
      organisms, and effective protocols for determining these adverse outcome pathways 
      are limited, especially in vivo. The increasing usage of graphene nanomaterials 
      can lead to the frequent exposure to marine organisms. Triphenyl phosphate (TPP), 
      an organophosphate flame retardant, is frequently detected in natural 
      environments. In this study, the combined toxic effects of co-exposure to 
      graphene and TPP was investigated in Mytilus galloprovincialis using 
      computational toxicology and multi-omics technology. Noticeably, graphene could 
      disturb the membrane stability and increase the tissue accumulation of TPP. The 
      adsorption behavior of TPP on graphene could inhibit the surface activity of 
      graphene. In the digestive gland, transcriptomics analysis revealed the 
      down-regulated genes in graphene + TPP treatment, including 
      glyceraldehyde-3-phosphate dehydrogenase (GAPDH), sorbitol dehydrogenase (SORD), 
      glutathione s-transferase mu 3 (GSTM3) and 4-aminobutyrate aminotransferase 
      (ABAT), were mainly associated with oxidative stress and energy metabolism. 
      Moreover, metabolic responses indicated that graphene + TPP could cause 
      disturbances in energy metabolism and osmotic regulation marked by differentially 
      altered ATP, glucose and taurine in mussels. These data underline the need for 
      further knowledge on the potential interactions of nanomaterials with existing 
      contaminants in marine organisms.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Li, Fei
AU  - Li F
AD  - CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, 
      Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences 
      (CAS), Yantai 264003, PR China; Shandong Key Laboratory of Coastal Environmental 
      Processes, YICCAS, Yantai 264003, PR China; Center for Ocean Mega-Science, 
      Chinese Academy of Sciences, Qingdao 266071, PR China. Electronic address: 
      fli@yic.ac.cn.
FAU - Meng, Xiangjing
AU  - Meng X
AD  - CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, 
      Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences 
      (CAS), Yantai 264003, PR China; Shandong Key Laboratory of Coastal Environmental 
      Processes, YICCAS, Yantai 264003, PR China; University of Chinese Academy of 
      Sciences, Beijing 100049, PR China.
FAU - Wang, Xiaoqing
AU  - Wang X
AD  - CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, 
      Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences 
      (CAS), Yantai 264003, PR China; Shandong Key Laboratory of Coastal Environmental 
      Processes, YICCAS, Yantai 264003, PR China; University of Chinese Academy of 
      Sciences, Beijing 100049, PR China.
FAU - Ji, Chenglong
AU  - Ji C
AD  - CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, 
      Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences 
      (CAS), Yantai 264003, PR China; Shandong Key Laboratory of Coastal Environmental 
      Processes, YICCAS, Yantai 264003, PR China; Center for Ocean Mega-Science, 
      Chinese Academy of Sciences, Qingdao 266071, PR China.
FAU - Wu, Huifeng
AU  - Wu H
AD  - CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, 
      Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences 
      (CAS), Yantai 264003, PR China; Shandong Key Laboratory of Coastal Environmental 
      Processes, YICCAS, Yantai 264003, PR China; Center for Ocean Mega-Science, 
      Chinese Academy of Sciences, Qingdao 266071, PR China. Electronic address: 
      hfwu@yic.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20211014
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Flame Retardants)
RN  - 0 (Organophosphates)
RN  - 0 (Water Pollutants, Chemical)
RN  - 7782-42-5 (Graphite)
RN  - YZE19Z66EA (triphenyl phosphate)
SB  - IM
MH  - Animals
MH  - *Flame Retardants/toxicity
MH  - *Graphite/toxicity
MH  - *Mytilus
MH  - Organophosphates/toxicity
MH  - *Water Pollutants, Chemical/toxicity
OTO - NOTNLM
OT  - Graphene
OT  - Joint effects
OT  - Multi-omics
OT  - Mytilus
OT  - Nanomaterials
OT  - Organophosphorus ester (OPEs)
EDAT- 2021/10/17 06:00
MHDA- 2021/11/11 06:00
CRDT- 2021/10/16 20:16
PHST- 2021/07/29 00:00 [received]
PHST- 2021/10/05 00:00 [revised]
PHST- 2021/10/12 00:00 [accepted]
PHST- 2021/10/17 06:00 [pubmed]
PHST- 2021/11/11 06:00 [medline]
PHST- 2021/10/16 20:16 [entrez]
AID - S0147-6513(21)01016-2 [pii]
AID - 10.1016/j.ecoenv.2021.112904 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2021 Dec 20;227:112904. doi: 
      10.1016/j.ecoenv.2021.112904. Epub 2021 Oct 14.