PMID- 34656234
OWN - NLM
STAT- MEDLINE
DCOM- 20211124
LR  - 20211124
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 93
DP  - 2021 Nov
TI  - Non-invasive assessment of cerebrospinal fluid flow dynamics using phase-contrast 
      magnetic resonance imaging in communicating hydrocephalus.
PG  - 116-121
LID - S0967-5868(21)00475-6 [pii]
LID - 10.1016/j.jocn.2021.09.019 [doi]
AB  - This work aims to evaluate the changes in cerebrospinal fluid (CSF) hydrodynamics 
      in patients diagnosed with communicating hydrocephalus. Besides, we establish the 
      relationship between CSF flow dynamic parameters on the midbrain aqueduct and 
      intracranial pressure (ICP). CSF hydrodynamics analysis was performed using 
      Phase-Contrast Magnetic Resonance Imaging (PC-MRI) techniques on the midbrain 
      aqueduct of 41 patients diagnosed with communicating hydrocephalus and 22 healthy 
      volunteers. The correlation between CSF average flow in the midbrain aqueduct and 
      intracranial pressure measured by Lumbar Puncture (LP) was assessed in patients 
      with hydrocephalus. Pearson correlation coefficient was used to establish the 
      correction between the average CSF flow of midbrain aqueduct and ICP. CSF dynamic 
      parameters of the midbrain aqueduct in hydrocephalus patients, including peak 
      positive velocity (7.348 cm/s), average velocity (0.623 cm/s), average flow 
      (50.799 mm(3)/s), and regions of interest (ROI) area (9.978 mm(2)) were 
      significantly higher than in the healthy controls (p < 0.05). This was after 
      adjusting the age, gender, heart rate, systolic blood pressure, diastolic blood 
      pressure, and body mass index. However, only the peak negative velocity of the 
      midbrain aqueduct did not significantly differ between the groups (p = 0.209). A 
      positive correlation was noted between the average flow (AF) of the midbrain 
      aqueducts and ICP in hydrocephalus patients (y (AF) = 0.386x (ICP)-33.738, 
      r = 0.787, p < 0.05). Reference data of CSF flow dynamic parameters was obtained 
      through the PC-MRI in middle-aged healthy volunteers and communicating 
      hydrocephalus patients. Although the sample size was constrained, this study has 
      significant contributions. For instance, a significant correlation was noted 
      between the average CSF flow of the aqueduct and ICP. This therefore provides a 
      reference for clinicians to monitor ICP in patients with hydrocephalus.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Liu, Shilin
AU  - Liu S
AD  - Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui Province, China.
FAU - Zhang, Yang
AU  - Zhang Y
AD  - Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui Province, China.
FAU - Jiang, Tao
AU  - Jiang T
AD  - Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui Province, China; Department of Neurosurgery, The Fourth 
      Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China. 
      Electronic address: jiangtao_aysfy@163.com.
FAU - Liu, Jia
AU  - Liu J
AD  - Department of Radiology, The Fourth Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui Province, China.
FAU - Jiang, Luwei
AU  - Jiang L
AD  - Department of Neurosurgery, The Fourth Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui Province, China.
FAU - Wu, Tingmiao
AU  - Wu T
AD  - Department of Radiology, The Fourth Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui Province, China.
LA  - eng
PT  - Journal Article
DEP - 20210917
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
SB  - IM
MH  - *Cerebral Aqueduct/diagnostic imaging
MH  - Cerebral Ventricles
MH  - Cerebrospinal Fluid/diagnostic imaging
MH  - Humans
MH  - *Hydrocephalus/diagnostic imaging
MH  - Intracranial Pressure
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
OTO - NOTNLM
OT  - Cerebrospinal fluid (CSF)
OT  - Hydrocephalus
OT  - Intracranial pressure (ICP)
OT  - Phase-contrast cine MRI (PC-MRI)
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/10/18 06:00
MHDA- 2021/11/25 06:00
CRDT- 2021/10/17 20:28
PHST- 2021/05/12 00:00 [received]
PHST- 2021/08/05 00:00 [revised]
PHST- 2021/09/07 00:00 [accepted]
PHST- 2021/10/17 20:28 [entrez]
PHST- 2021/10/18 06:00 [pubmed]
PHST- 2021/11/25 06:00 [medline]
AID - S0967-5868(21)00475-6 [pii]
AID - 10.1016/j.jocn.2021.09.019 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2021 Nov;93:116-121. doi: 10.1016/j.jocn.2021.09.019. Epub 2021 
      Sep 17.