PMID- 34656440
OWN - NLM
STAT- MEDLINE
DCOM- 20220322
LR  - 20220418
IS  - 1444-2892 (Electronic)
IS  - 1443-9506 (Linking)
VI  - 31
IP  - 4
DP  - 2022 Apr
TI  - Impact of Surgical and Transcatheter Aortic Valve Replacement on Frailty Score.
PG  - 566-574
LID - S1443-9506(21)01255-5 [pii]
LID - 10.1016/j.hlc.2021.09.014 [doi]
AB  - OBJECTIVE: Frailty is common in the aortic stenosis (AS) population and impacts 
      outcomes after both transcatheter and surgical aortic valve replacement (TAVR and 
      sAVR, respectively). Frailty can significantly impact the decision regarding the 
      suitability of a patient for aortic valve intervention, with frail patients often 
      excluded. Since many frailty tools use indicators which may be influenced by AS 
      itself, some of which are subjectively symptom driven, we sought to determine the 
      impact of intervention on frailty scores. METHODS: A prospective, observational 
      cohort study included patients being assessed for aortic valve (AV) intervention 
      with either TAVR or sAVR due to severe aortic stenosis. Patients were assessed 
      for symptoms at baseline, and 1- and 6-months post intervention subjectively, 
      using the New York Heart Association (NYHA) class and the Kansas City 
      Cardiomyopathy Questionnaire (KCCQ), and objectively, using a 6-minute walk test 
      (6MWT). These were compared with frailty at baseline and final review using the 
      Fried Frailty Scale (FFS). RESULTS AND CONCLUSIONS: Sixty-six (66) patients 
      completed pre- and post-intervention reviews. The mean FFS score was 
      significantly lower, indicating less frailty, at 6 months relative to pre 
      procedure (1.18 vs 1.73, p=0.002). This correlated with the change in symptoms 
      (p<0.001). Between intervention groups, the final mean FFS of both groups 
      decreased significantly, with TAVR to 1.33 (p=0.030) and sAVR to 0.8 (p=0.015). 
      There was no difference in the degree of improvement between interventions 
      (p=0.517). Aortic valve intervention improves frailty scores in both TAVR and 
      sAVR treated patients.
CI  - Copyright (c) 2021 Australian and New Zealand Society of Cardiac and Thoracic 
      Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). 
      Published by Elsevier B.V. All rights reserved.
FAU - Jones, Dylan R
AU  - Jones DR
AD  - Flinders University, Adelaide, SA, Australia; Flinders Medical Centre, Adelaide, 
      SA, Australia. Electronic address: dylan.jones@flinders.edu.au.
FAU - Chew, Derek P
AU  - Chew DP
AD  - Flinders University, Adelaide, SA, Australia; Flinders Medical Centre, Adelaide, 
      SA, Australia.
FAU - Horsfall, Matthew J
AU  - Horsfall MJ
AD  - Flinders Medical Centre, Adelaide, SA, Australia.
FAU - Sinhal, Ajay R
AU  - Sinhal AR
AD  - Flinders Medical Centre, Adelaide, SA, Australia.
FAU - Joseph, Majo X
AU  - Joseph MX
AD  - Flinders Medical Centre, Adelaide, SA, Australia.
FAU - Baker, Robert A
AU  - Baker RA
AD  - Flinders University, Adelaide, SA, Australia; Flinders Medical Centre, Adelaide, 
      SA, Australia.
FAU - Bennetts, Jayme S
AU  - Bennetts JS
AD  - Flinders University, Adelaide, SA, Australia; Flinders Medical Centre, Adelaide, 
      SA, Australia.
FAU - Selvanayagam, Joseph B
AU  - Selvanayagam JB
AD  - Flinders University, Adelaide, SA, Australia; Flinders Medical Centre, Adelaide, 
      SA, Australia.
FAU - Harris, Josephine H
AU  - Harris JH
AD  - Flinders Medical Centre, Adelaide, SA, Australia.
FAU - De Pasquale, Carmine G
AU  - De Pasquale CG
AD  - Flinders University, Adelaide, SA, Australia; Flinders Medical Centre, Adelaide, 
      SA, Australia.
FAU - Lehman, Sam J
AU  - Lehman SJ
AD  - Flinders University, Adelaide, SA, Australia; Flinders Medical Centre, Adelaide, 
      SA, Australia.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20211014
PL  - Australia
TA  - Heart Lung Circ
JT  - Heart, lung & circulation
JID - 100963739
SB  - IM
CIN - Heart Lung Circ. 2022 Apr;31(4):460-461. PMID: 35181227
MH  - Aortic Valve/surgery
MH  - *Aortic Valve Stenosis/diagnosis/surgery
MH  - *Frailty/diagnosis
MH  - *Heart Valve Prosthesis Implantation/methods
MH  - Humans
MH  - Prospective Studies
MH  - Risk Factors
MH  - *Transcatheter Aortic Valve Replacement/methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Aortic stenosis
OT  - Aortic valve replacement
OT  - Frailty
OT  - Symptoms
OT  - TAVR
EDAT- 2021/10/18 06:00
MHDA- 2022/03/23 06:00
CRDT- 2021/10/17 20:34
PHST- 2021/03/25 00:00 [received]
PHST- 2021/08/23 00:00 [revised]
PHST- 2021/09/06 00:00 [accepted]
PHST- 2021/10/18 06:00 [pubmed]
PHST- 2022/03/23 06:00 [medline]
PHST- 2021/10/17 20:34 [entrez]
AID - S1443-9506(21)01255-5 [pii]
AID - 10.1016/j.hlc.2021.09.014 [doi]
PST - ppublish
SO  - Heart Lung Circ. 2022 Apr;31(4):566-574. doi: 10.1016/j.hlc.2021.09.014. Epub 
      2021 Oct 14.