PMID- 34656858
OWN - NLM
STAT- MEDLINE
DCOM- 20211110
LR  - 20220428
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 227
DP  - 2021 Dec 20
TI  - Association between the total plasma isomers of per- and polyfluoroalkyl 
      substances and erythrograms in young and middle-aged Taiwanese populations.
PG  - 112902
LID - S0147-6513(21)01014-9 [pii]
LID - 10.1016/j.ecoenv.2021.112902 [doi]
AB  - PURPOSE: Per- and polyfluoroalkyl substances (PFAS) are human-made chemicals used 
      in daily use products. Recent studies have shown that different perfluorooctanoic 
      acid (PFOA) and/or perfluorooctane sulfonate (PFOS) isomers may have different 
      biological effects. In vitro studies have also reported that PFAS exposure can 
      alter the structure of hemoglobin (Hb). In epidemiology, however, few studies 
      have investigated the relationship between PFAS exposure and erythrocytes. 
      Additionally, the correlation between PFOA/PFOS isomers and full erythrograms has 
      never been explored. APPROACH AND RESULTS: In cohorts comprising young and 
      middle-aged Taiwanese populations, we enrolled 1483 participants (aged between 12 
      and 63 years) to analyze the correlations between the plasma levels of PFOA/PFOS 
      isomers and whole-blood erythrograms. The study comprised 868 men and 615 women 
      with a mean age of 31.2 years. When all PFOA/PFOS isomers were entered into the 
      multiple linear regression model, the linear PFOA (L-PFOA) levels were positively 
      correlated with the Hb, hematocrit (HCT), mean corpuscular volume (MCV), and mean 
      corpuscular hemoglobin (MCH) levels while the branched PFOS (B-PFOS) levels were 
      positively associated with the Hb, HCT, and mean corpuscular hemoglobin 
      concentration (MCHC). The mean value of Hb was the highest (14.66 mg/dL (95% CI 
      =14.52-14.80); P for trend <0.001) when both the L-PFOA and B-PFOS levels were 
      above the 50th percentile. CONCLUSIONS: The results imply that PFOA/PFOS isomers 
      may increase the weight and volume of Hb/RBC and that L-PFOA/B-PFOS may have an 
      additive effect on the Hb levels. However, it is also possible PFAS detected at a 
      higher concentration may due to its binding to higher levels of Hb. Further 
      studies are needed to investigate the effects of PFOA/PFOS isomers on RBCs in 
      humans.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Lin, Chien-Yu
AU  - Lin CY
AD  - Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, 
      Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City 242, 
      Taiwan; Department of Environmental Engineering and Health, Yuanpei University of 
      Medical Technology, Hsinchu 300, Taiwan.
FAU - Lee, Hui-Ling
AU  - Lee HL
AD  - Department of Chemistry, Fu Jen Catholic University, New Taipei City 242, Taiwan.
FAU - Wang, Chikang
AU  - Wang C
AD  - Department of Environmental Engineering and Health, Yuanpei University of Medical 
      Technology, Hsinchu 300, Taiwan.
FAU - Sung, Fung-Chang
AU  - Sung FC
AD  - Department of Health Services Administration, China Medical University College of 
      Public Health, Taichung 404, Taiwan; Department of Food Nutrition and Health 
      Biotechnology, Asia University, Taichung 413, Taiwan.
FAU - Su, Ta-Chen
AU  - Su TC
AD  - Department of Environmental and Occupational Medicine, National Taiwan University 
      Hospital, Taipei 100, Taiwan; Division of Cardiology, Department of Internal 
      Medicine, National Taiwan University Hospital, Taipei 100, Taiwan; Institute of 
      Environmental and Occupational Health Sciences, College of Public Health, 
      National Taiwan University, Taipei 100, Taiwan. Electronic address: 
      tachensu@ntu.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20211014
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Alkanesulfonic Acids/toxicity
MH  - Caprylates/toxicity
MH  - Child
MH  - *Environmental Pollutants
MH  - Female
MH  - *Fluorocarbons/toxicity
MH  - Humans
MH  - Isomerism
MH  - Male
MH  - Middle Aged
MH  - Plasma
MH  - Young Adult
OTO - NOTNLM
OT  - Erythrogram
OT  - Isomers
OT  - Per- and polyfluoroalkyl substances (PFAS)
OT  - Perfluorooctane sulfonate (PFOS)
OT  - Perfluorooctanoic acid (PFOA)
OT  - Red blood cells
EDAT- 2021/10/18 06:00
MHDA- 2021/11/11 06:00
CRDT- 2021/10/17 20:45
PHST- 2021/07/20 00:00 [received]
PHST- 2021/10/09 00:00 [revised]
PHST- 2021/10/11 00:00 [accepted]
PHST- 2021/10/18 06:00 [pubmed]
PHST- 2021/11/11 06:00 [medline]
PHST- 2021/10/17 20:45 [entrez]
AID - S0147-6513(21)01014-9 [pii]
AID - 10.1016/j.ecoenv.2021.112902 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2021 Dec 20;227:112902. doi: 
      10.1016/j.ecoenv.2021.112902. Epub 2021 Oct 14.